Preparation and solid state properties of cyclodextrin complexes of selected drug molecules

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dc.contributor.advisorCaira, Mino Ren_ZA
dc.contributor.authorMvula, Eino Natangween_ZA
dc.date.accessioned2016-03-17T07:18:50Z
dc.date.available2016-03-17T07:18:50Z
dc.date.issued1999en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractA large number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin (Trimeb) 3, complexes with clofibric acid as well as the heptakis(2,3,6j·tri-O-methyl)- β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal X-ray analysis.en_ZA
dc.identifier.apacitationMvula, E. N. (1999). <i>Preparation and solid state properties of cyclodextrin complexes of selected drug molecules</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/17902en_ZA
dc.identifier.chicagocitationMvula, Eino Natangwe. <i>"Preparation and solid state properties of cyclodextrin complexes of selected drug molecules."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1999. http://hdl.handle.net/11427/17902en_ZA
dc.identifier.citationMvula, E. 1999. Preparation and solid state properties of cyclodextrin complexes of selected drug molecules. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mvula, Eino Natangwe AB - A large number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug molecules. The preparation of β-cyclodextrin CP-CD), y-cyclodextrin (y-CD), heptakis(2,6-di-OJ, methyl)-β-cyclodextrin (Dimeb) and heptakis(2,3,6·tri-0-methyl)- β-cyclodextrin (Trimeb) 3, complexes with clofibric acid as well as the heptakis(2,3,6j·tri-O-methyl)- β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal X-ray analysis. DA - 1999 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1999 T1 - Preparation and solid state properties of cyclodextrin complexes of selected drug molecules TI - Preparation and solid state properties of cyclodextrin complexes of selected drug molecules UR - http://hdl.handle.net/11427/17902 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/17902
dc.identifier.vancouvercitationMvula EN. Preparation and solid state properties of cyclodextrin complexes of selected drug molecules. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1999 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/17902en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titlePreparation and solid state properties of cyclodextrin complexes of selected drug moleculesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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