Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital

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dc.contributor.authorMudau, Maandaen_ZA
dc.contributor.authorJacobson, Rachaelen_ZA
dc.contributor.authorMinenza, Nadiaen_ZA
dc.contributor.authorKuonza, Lazarusen_ZA
dc.contributor.authorMorris, Vidaen_ZA
dc.contributor.authorEngelbrecht, Heatheren_ZA
dc.contributor.authorNicol, Mark Pen_ZA
dc.contributor.authorBamford, Colleenen_ZA
dc.date.accessioned2016-01-11T06:55:16Z
dc.date.available2016-01-11T06:55:16Z
dc.date.issued2013en_ZA
dc.description.abstractObjective: To describe an outbreak of multi-resistant Pseudomonas aeruginosa bloodstream infections (MRPA-BSI) that occurred in the haematology ward of a tertiary academic hospital in Cape Town, South Africa, and determine risk factors for acquisition of MRPA-BSI. METHODS: The outbreak investigation included a search for additional cases, review of patient records, environmental and staff screening, molecular typing using pulsed-field gel electrophoresis (PFGE) and Multi-locus sequencing (MLST) and a retrospective case-control study. RESULTS: Ten MRPA-BSI cases occurred in the haematology ward between January 2010 and January 2011. The case fatality rate was 80%. Staff screening specimens were negative for MRPA and an environmental source was not identified. PFGE showed that 9/10 isolates were related. MLST showed that 3 of these 9 isolates belonged to Sequence type (ST) 233 while the unrelated isolate belonged to ST260. CONCLUSION: We have described an outbreak of MRPA-BSI occurring over an extended period of time among neutropenic haematology patients. Molecular typing confirms that the outbreak was predominantly due to a single strain. The source of the outbreak was not identified, but the outbreak appears to have been controlled following intensive infection control measures.en_ZA
dc.identifier.apacitationMudau, M., Jacobson, R., Minenza, N., Kuonza, L., Morris, V., Engelbrecht, H., ... Bamford, C. (2013). Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital. <i>PLoS One</i>, http://hdl.handle.net/11427/16298en_ZA
dc.identifier.chicagocitationMudau, Maanda, Rachael Jacobson, Nadia Minenza, Lazarus Kuonza, Vida Morris, Heather Engelbrecht, Mark P Nicol, and Colleen Bamford "Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/16298en_ZA
dc.identifier.citationMudau, M., Jacobson, R., Minenza, N., Kuonza, L., Morris, V., Engelbrecht, H., ... & Bamford, C. (2013). Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital. PloS one, 8(3), e55985. doi:10.1371/journal.pone.0055985en_ZA
dc.identifier.ris TY - Journal Article AU - Mudau, Maanda AU - Jacobson, Rachael AU - Minenza, Nadia AU - Kuonza, Lazarus AU - Morris, Vida AU - Engelbrecht, Heather AU - Nicol, Mark P AU - Bamford, Colleen AB - Objective: To describe an outbreak of multi-resistant Pseudomonas aeruginosa bloodstream infections (MRPA-BSI) that occurred in the haematology ward of a tertiary academic hospital in Cape Town, South Africa, and determine risk factors for acquisition of MRPA-BSI. METHODS: The outbreak investigation included a search for additional cases, review of patient records, environmental and staff screening, molecular typing using pulsed-field gel electrophoresis (PFGE) and Multi-locus sequencing (MLST) and a retrospective case-control study. RESULTS: Ten MRPA-BSI cases occurred in the haematology ward between January 2010 and January 2011. The case fatality rate was 80%. Staff screening specimens were negative for MRPA and an environmental source was not identified. PFGE showed that 9/10 isolates were related. MLST showed that 3 of these 9 isolates belonged to Sequence type (ST) 233 while the unrelated isolate belonged to ST260. CONCLUSION: We have described an outbreak of MRPA-BSI occurring over an extended period of time among neutropenic haematology patients. Molecular typing confirms that the outbreak was predominantly due to a single strain. The source of the outbreak was not identified, but the outbreak appears to have been controlled following intensive infection control measures. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pone.0055985 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital TI - Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital UR - http://hdl.handle.net/11427/16298 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16298
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0055985
dc.identifier.vancouvercitationMudau M, Jacobson R, Minenza N, Kuonza L, Morris V, Engelbrecht H, et al. Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospital. PLoS One. 2013; http://hdl.handle.net/11427/16298.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2013 Mudau et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherPseudomonas aeruginosaen_ZA
dc.subject.otherBloodstream infectionsen_ZA
dc.subject.otherHematologyen_ZA
dc.subject.otherInfectious disease controlen_ZA
dc.subject.otherGram negative bacteriaen_ZA
dc.subject.otherAcute myeloid leukemiaen_ZA
dc.subject.otherAntibioticsen_ZA
dc.subject.otherNosocomial infectionsen_ZA
dc.titleOutbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the haematology unit of a South African academic hospitalen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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