The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System

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dc.contributor.authorBasson, Abigailen_ZA
dc.contributor.authorSwart, Rinaen_ZA
dc.contributor.authorJordaan, Esmeen_ZA
dc.contributor.authorMazinu, Mikatekoen_ZA
dc.contributor.authorWatermeyer, Gillianen_ZA
dc.date.accessioned2015-11-18T07:11:46Z
dc.date.available2015-11-18T07:11:46Z
dc.date.issued2014en_ZA
dc.description.abstractBACKGROUND: Inter-racial differences in disease characteristics and in the management of Crohn's disease (CD) have been described in African American and Asian subjects, however for the racial groups in South Africa, no such recent literature exists. METHODS: A cross sectional study of all consecutive CD patients seen at 2 large inflammatory bowel disease (IBD) referral centers in the Western Cape, South Africa between September 2011 and January 2013 was performed. Numerous demographic and clinical variables at diagnosis and date of study enrolment were identified using an investigator administered questionnaire as well as clinical examination and patient case notes. Using predefined definitions, disease behavior was stratified as ‘complicated’ or ‘uncomplicated’. RESULTS: One hundred and ninety four CD subjects were identified; 35 (18%) were white, 152 (78%) were Cape Coloured and 7(4%) were black. On multiple logistic regression analysis Cape Coloureds were significantly more likely to develop ‘complicated’ CD (60% vs. 9%, p = 0.023) during the disease course when compared to white subjects. In addition, significantly more white subjects had successfully discontinued cigarette smoking at study enrolment (31% vs. 7% reduction, p = 0.02). No additional inter-racial differences were found. A low proportion of IBD family history was observed among the non-white subjects. CONCLUSIONS: Cape Coloured patients were significantly more likely to develop ‘complicated’ CD over time when compared to whites.en_ZA
dc.identifier.apacitationBasson, A., Swart, R., Jordaan, E., Mazinu, M., & Watermeyer, G. (2014). The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System. <i>PLoS One</i>, http://hdl.handle.net/11427/15143en_ZA
dc.identifier.chicagocitationBasson, Abigail, Rina Swart, Esme Jordaan, Mikateko Mazinu, and Gillian Watermeyer "The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System." <i>PLoS One</i> (2014) http://hdl.handle.net/11427/15143en_ZA
dc.identifier.citationBasson, A., Swart, R., Jordaan, E., Mazinu, M., & Watermeyer, G. (2013). The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System. PloS one, 9(8), e104859. doi:10.1371/journal.pone.0104859en_ZA
dc.identifier.ris TY - Journal Article AU - Basson, Abigail AU - Swart, Rina AU - Jordaan, Esme AU - Mazinu, Mikateko AU - Watermeyer, Gillian AB - BACKGROUND: Inter-racial differences in disease characteristics and in the management of Crohn's disease (CD) have been described in African American and Asian subjects, however for the racial groups in South Africa, no such recent literature exists. METHODS: A cross sectional study of all consecutive CD patients seen at 2 large inflammatory bowel disease (IBD) referral centers in the Western Cape, South Africa between September 2011 and January 2013 was performed. Numerous demographic and clinical variables at diagnosis and date of study enrolment were identified using an investigator administered questionnaire as well as clinical examination and patient case notes. Using predefined definitions, disease behavior was stratified as ‘complicated’ or ‘uncomplicated’. RESULTS: One hundred and ninety four CD subjects were identified; 35 (18%) were white, 152 (78%) were Cape Coloured and 7(4%) were black. On multiple logistic regression analysis Cape Coloureds were significantly more likely to develop ‘complicated’ CD (60% vs. 9%, p = 0.023) during the disease course when compared to white subjects. In addition, significantly more white subjects had successfully discontinued cigarette smoking at study enrolment (31% vs. 7% reduction, p = 0.02). No additional inter-racial differences were found. A low proportion of IBD family history was observed among the non-white subjects. CONCLUSIONS: Cape Coloured patients were significantly more likely to develop ‘complicated’ CD over time when compared to whites. DA - 2014 DB - OpenUCT DO - 10.1371/journal.pone.0104859 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System TI - The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System UR - http://hdl.handle.net/11427/15143 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15143
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0104859
dc.identifier.vancouvercitationBasson A, Swart R, Jordaan E, Mazinu M, Watermeyer G. The Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification System. PLoS One. 2014; http://hdl.handle.net/11427/15143.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2014 Basson et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherNatural history of diseaseen_ZA
dc.subject.otherSouth Africaen_ZA
dc.subject.otherTuberculosis diagnosis and managementen_ZA
dc.subject.otherInflammatory bowel diseaseen_ZA
dc.subject.otherEthnic epidemiologyen_ZA
dc.subject.otherDemographyen_ZA
dc.subject.otherSmoking habitsen_ZA
dc.subject.otherCrohn's diseaseen_ZA
dc.titleThe Association between Race and Crohn's Disease Phenotype in the Western Cape Population of South Africa, Defined by the Montreal Classification Systemen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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