Management of paediatric immune thrombocytopaenia in a South African centre from 1991-2011

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dc.contributor.advisorDavidson, Alanen_ZA
dc.contributor.authorAkhalwaya, Shehnaazen_ZA
dc.date.accessioned2017-01-18T13:09:56Z
dc.date.available2017-01-18T13:09:56Z
dc.date.issued2016en_ZA
dc.description.abstractThree hundred and seventeen patients meeting the diagnostic criteria for immune thrombocytopenia presented to Red Cross War Memorial Children's Hospital between 1991 and 2011. We retrospectively reviewed these patients in order to describe patient demography, the natural history of the disease, and different approaches to diagnosis and management. There were 162 males and 155 female patients. The median age of onset was 3.48 years old (IQR 1.66-6.36). In the 4 weeks preceding presentation, 98 (31%) patients had a viral illness. The median presenting platelet count was 7 x 109/L (IQR 3-14.5). Petechiae were the most common clinical sign at presentation (58%; 184/317). None of the patients presented with intracranial haemorrhages. The majority of patients in the study were admitted (234/317; 74%) with a median stay of 4 days (IQR 0-6). Bone marrow aspirates (BMA) were performed in 188 patients (59%). There was a reduction in BMA from 1991-2000 to 2001-2011 (p<0.001). There was an increase in the percentage of patients treated from 1991-2000 (77/170; 44%) to 2001-2011 (99/147, 67% p< 0.001). Resolution occurred in 75% of patients with a median time to resolution of 31 days (IQR 11-73 days). When we analysed the "survival estimate" from the 2 decades, despite differing rates of BMA, treatment rates and regimens, there was no statistical difference in resolution.en_ZA
dc.identifier.apacitationAkhalwaya, S. (2016). <i>Management of paediatric immune thrombocytopaenia in a South African centre from 1991-2011</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/22793en_ZA
dc.identifier.chicagocitationAkhalwaya, Shehnaaz. <i>"Management of paediatric immune thrombocytopaenia in a South African centre from 1991-2011."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2016. http://hdl.handle.net/11427/22793en_ZA
dc.identifier.citationAkhalwaya, S. 2016. Management of paediatric immune thrombocytopaenia in a South African centre from 1991-2011. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Akhalwaya, Shehnaaz AB - Three hundred and seventeen patients meeting the diagnostic criteria for immune thrombocytopenia presented to Red Cross War Memorial Children's Hospital between 1991 and 2011. We retrospectively reviewed these patients in order to describe patient demography, the natural history of the disease, and different approaches to diagnosis and management. There were 162 males and 155 female patients. The median age of onset was 3.48 years old (IQR 1.66-6.36). In the 4 weeks preceding presentation, 98 (31%) patients had a viral illness. The median presenting platelet count was 7 x 109/L (IQR 3-14.5). Petechiae were the most common clinical sign at presentation (58%; 184/317). None of the patients presented with intracranial haemorrhages. The majority of patients in the study were admitted (234/317; 74%) with a median stay of 4 days (IQR 0-6). Bone marrow aspirates (BMA) were performed in 188 patients (59%). There was a reduction in BMA from 1991-2000 to 2001-2011 (p<0.001). There was an increase in the percentage of patients treated from 1991-2000 (77/170; 44%) to 2001-2011 (99/147, 67% p< 0.001). Resolution occurred in 75% of patients with a median time to resolution of 31 days (IQR 11-73 days). When we analysed the "survival estimate" from the 2 decades, despite differing rates of BMA, treatment rates and regimens, there was no statistical difference in resolution. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Management of paediatric immune thrombocytopaenia in a South African centre from 1991-2011 TI - Management of paediatric immune thrombocytopaenia in a South African centre from 1991-2011 UR - http://hdl.handle.net/11427/22793 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/22793
dc.identifier.vancouvercitationAkhalwaya S. Management of paediatric immune thrombocytopaenia in a South African centre from 1991-2011. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/22793en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPaediatricsen_ZA
dc.titleManagement of paediatric immune thrombocytopaenia in a South African centre from 1991-2011en_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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