Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children

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dc.contributor.advisorMcIlleron, Helenen_ZA
dc.contributor.advisorSmith, Peteen_ZA
dc.contributor.authorAmlabu, Veronica Asibien_ZA
dc.date.accessioned2014-07-28T18:21:09Z
dc.date.available2014-07-28T18:21:09Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractThe World Health Organization recommends the use of isoniazid preventive therapy to reduce the incidence of tuberculosis disease in populations at risk for developing the disease. Adherence to isoniazid preventive therapy is needful for efficacy. A urine assay known as the Arkansas test is widely used to monitor the ingestion of isoniazid. However, this test is limited by a drop in sensitivity with increasing time post isoniazid dose. Furthermore, results from the test can be affected by observer variation in colour changes, concomitant medications, urinary dilution, and presence of other substances in urine. Moreover, the Arkansas test results have not been evaluated against objective measurement of isoniazid and acetylisoniazid urine concentrations. This study seeks to measure the urine concentrations of isoniazid and acetylisoniazid at different time points after a dose in children, in order to establish reference ranges for liquid chromatography tandem mass spectrometry measurements of urine isoniazid and acetylisoniazid, as well as the Arkansas method. The reference ranges would provide a standard which can be used to estimate the probability of adherence to prior doses.en_ZA
dc.identifier.apacitationAmlabu, V. A. (2013). <i>Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/3307en_ZA
dc.identifier.chicagocitationAmlabu, Veronica Asibi. <i>"Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2013. http://hdl.handle.net/11427/3307en_ZA
dc.identifier.citationAmlabu, V. 2013. Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Amlabu, Veronica Asibi AB - The World Health Organization recommends the use of isoniazid preventive therapy to reduce the incidence of tuberculosis disease in populations at risk for developing the disease. Adherence to isoniazid preventive therapy is needful for efficacy. A urine assay known as the Arkansas test is widely used to monitor the ingestion of isoniazid. However, this test is limited by a drop in sensitivity with increasing time post isoniazid dose. Furthermore, results from the test can be affected by observer variation in colour changes, concomitant medications, urinary dilution, and presence of other substances in urine. Moreover, the Arkansas test results have not been evaluated against objective measurement of isoniazid and acetylisoniazid urine concentrations. This study seeks to measure the urine concentrations of isoniazid and acetylisoniazid at different time points after a dose in children, in order to establish reference ranges for liquid chromatography tandem mass spectrometry measurements of urine isoniazid and acetylisoniazid, as well as the Arkansas method. The reference ranges would provide a standard which can be used to estimate the probability of adherence to prior doses. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children TI - Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children UR - http://hdl.handle.net/11427/3307 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3307
dc.identifier.vancouvercitationAmlabu VA. Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3307en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPharmacologyen_ZA
dc.titleIsoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in childrenen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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