Paediatric cardiac anaesthesia in sickle cell disease : a case series

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dc.contributor.advisorThomas, Jennyen_ZA
dc.contributor.authorJanse van Rensburg, P Jen_ZA
dc.date.accessioned2015-08-27T12:31:44Z
dc.date.available2015-08-27T12:31:44Z
dc.date.issued2015en_ZA
dc.description.abstractSickle cell disease (SCD) is the most common inherited haematological disorder, producing a mutation of the haemoglobin molecule known as haemoglobin S (HbS). The presence of HbS in the erythrocyte makes it prone to sickling - a process which may lead to vaso-occlusive injury, haemolysis and a hypercoagulable state. Sickling is precipitated by dehydration, hypoxia, hypothermia, acidosis and low flow states. Over time, multi-organ damage develops with significant morbidity and mortality. Paediatric patients with SCD and congenital heart defects may require anaesthesia for corrective cardiac surgery on cardiopulmonary bypass (CPB). During the perioperative period these high-risk patients may suffer significant complications when exposed to the conditions that favour erythrocyte sickling. This case series details our experience of four paediatric patients with SCD patients who underwent corrective cardiac surgery at Red Cross War Memorial Children’s Hospital. The pathophysiology is discussed and the perioperative management of transfusion, cardiopulmonary bypass and temperature regulation is highlighted.en_ZA
dc.identifier.apacitationJanse van Rensburg, P. J. (2015). <i>Paediatric cardiac anaesthesia in sickle cell disease : a case series</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Anaesthesia. Retrieved from http://hdl.handle.net/11427/13790en_ZA
dc.identifier.chicagocitationJanse van Rensburg, P J. <i>"Paediatric cardiac anaesthesia in sickle cell disease : a case series."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Anaesthesia, 2015. http://hdl.handle.net/11427/13790en_ZA
dc.identifier.citationJanse van Rensburg, P. 2015. Paediatric cardiac anaesthesia in sickle cell disease : a case series. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Janse van Rensburg, P J AB - Sickle cell disease (SCD) is the most common inherited haematological disorder, producing a mutation of the haemoglobin molecule known as haemoglobin S (HbS). The presence of HbS in the erythrocyte makes it prone to sickling - a process which may lead to vaso-occlusive injury, haemolysis and a hypercoagulable state. Sickling is precipitated by dehydration, hypoxia, hypothermia, acidosis and low flow states. Over time, multi-organ damage develops with significant morbidity and mortality. Paediatric patients with SCD and congenital heart defects may require anaesthesia for corrective cardiac surgery on cardiopulmonary bypass (CPB). During the perioperative period these high-risk patients may suffer significant complications when exposed to the conditions that favour erythrocyte sickling. This case series details our experience of four paediatric patients with SCD patients who underwent corrective cardiac surgery at Red Cross War Memorial Children’s Hospital. The pathophysiology is discussed and the perioperative management of transfusion, cardiopulmonary bypass and temperature regulation is highlighted. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Paediatric cardiac anaesthesia in sickle cell disease : a case series TI - Paediatric cardiac anaesthesia in sickle cell disease : a case series UR - http://hdl.handle.net/11427/13790 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13790
dc.identifier.vancouvercitationJanse van Rensburg PJ. Paediatric cardiac anaesthesia in sickle cell disease : a case series. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Anaesthesia, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13790en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Anaesthesiaen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherAnaesthesiaen_ZA
dc.titlePaediatric cardiac anaesthesia in sickle cell disease : a case seriesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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