Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1

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dc.contributor.authorMarakalala, Mohlopheni Jen_ZA
dc.contributor.authorVautier, Simonen_ZA
dc.contributor.authorPotrykus, Joannaen_ZA
dc.contributor.authorWalker, Louise Aen_ZA
dc.contributor.authorShepardson, Kelly Men_ZA
dc.contributor.authorHopke, Alexen_ZA
dc.contributor.authorMora-Montes, Hector Men_ZA
dc.contributor.authorKerrigan, Annen_ZA
dc.contributor.authorNetea, Mihai Gen_ZA
dc.contributor.authorMurray, Graeme Ien_ZA
dc.date.accessioned2015-11-23T12:35:12Z
dc.date.available2015-11-23T12:35:12Z
dc.date.issued2013en_ZA
dc.description.abstractAuthor Summary Dectin-1 is a pattern recognition receptor recognising the fungal cell-wall component, β-glucan, and plays an essential role in controlling C. albicans infections in both mouse and man. Candida albicans is part of the normal human microflora, yet is capable of causing superficial mucosal infections as well as life-threatening invasive diseases, particularly in patients whose immune function is compromised. Here we found that the contribution of Dectin-1 is limited to specific strains of C. albicans ; effects which are due to the differential adaptation of these pathogens during infection. Importantly, C. albicans strains showed variations in both the composition and nature of their cell walls, and it was these differences which influenced the role of Dectin-1. Crucially, we found that we could alter the fungal cell wall, and subsequent interactions with the host, using antifungal drugs. These findings have substantial implications for our understanding of the factors contributing to human susceptibility to infections with C. albicans , but also treatment strategies.en_ZA
dc.identifier.apacitationMarakalala, M. J., Vautier, S., Potrykus, J., Walker, L. A., Shepardson, K. M., Hopke, A., ... Murray, G. I. (2013). Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1. <i>PLoS One</i>, http://hdl.handle.net/11427/15319en_ZA
dc.identifier.chicagocitationMarakalala, Mohlopheni J, Simon Vautier, Joanna Potrykus, Louise A Walker, Kelly M Shepardson, Alex Hopke, Hector M Mora-Montes, Ann Kerrigan, Mihai G Netea, and Graeme I Murray "Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/15319en_ZA
dc.identifier.citationMarakalala, M. J., Vautier, S., Potrykus, J., Walker, L. A., Shepardson, K. M., Hopke, A., ... & Brown, G. D. (2013). Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1. PLoS Pathog, 9(4), e1003315. doi:10.1371/journal.ppat.1003315en_ZA
dc.identifier.ris TY - Journal Article AU - Marakalala, Mohlopheni J AU - Vautier, Simon AU - Potrykus, Joanna AU - Walker, Louise A AU - Shepardson, Kelly M AU - Hopke, Alex AU - Mora-Montes, Hector M AU - Kerrigan, Ann AU - Netea, Mihai G AU - Murray, Graeme I AB - Author Summary Dectin-1 is a pattern recognition receptor recognising the fungal cell-wall component, β-glucan, and plays an essential role in controlling C. albicans infections in both mouse and man. Candida albicans is part of the normal human microflora, yet is capable of causing superficial mucosal infections as well as life-threatening invasive diseases, particularly in patients whose immune function is compromised. Here we found that the contribution of Dectin-1 is limited to specific strains of C. albicans ; effects which are due to the differential adaptation of these pathogens during infection. Importantly, C. albicans strains showed variations in both the composition and nature of their cell walls, and it was these differences which influenced the role of Dectin-1. Crucially, we found that we could alter the fungal cell wall, and subsequent interactions with the host, using antifungal drugs. These findings have substantial implications for our understanding of the factors contributing to human susceptibility to infections with C. albicans , but also treatment strategies. DA - 2013 DB - OpenUCT DO - 10.1371/journal.ppat.1003315 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1 TI - Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1 UR - http://hdl.handle.net/11427/15319 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15319
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1003315
dc.identifier.vancouvercitationMarakalala MJ, Vautier S, Potrykus J, Walker LA, Shepardson KM, Hopke A, et al. Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1. PLoS One. 2013; http://hdl.handle.net/11427/15319.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2013 Marakalala et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherCandida albicansen_ZA
dc.subject.otherCell wallsen_ZA
dc.subject.otherFungal diseasesen_ZA
dc.subject.otherChitinen_ZA
dc.subject.otherKidneysen_ZA
dc.subject.otherCytokinesen_ZA
dc.subject.otherFungal geneticsen_ZA
dc.subject.otherInflammationen_ZA
dc.titleDifferential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1en_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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