The effects of amlodipine on exercise performance in mild to moderate essential hypertensives

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dc.contributor.advisorDerman, Wayneen_ZA
dc.contributor.authorGillies, Hunter Campbellen_ZA
dc.date.accessioned2018-01-25T13:54:44Z
dc.date.available2018-01-25T13:54:44Z
dc.date.issued1997en_ZA
dc.description.abstractThe effect of the long acting dihydropyridine calcium channel antagonist, amlodipine, on the exercise performance of hypertensive patients is not known. The aim of this study was to determine the effects of amlodipine on maximal (MAX), prolonged submaximal (PSX) and on skeletal muscle function (SMF) in patients with mild hypertension. In a double-blind randomised crossover trial, ten physically active hypertensive patients performed i) graded exercise to exhaustion for determination of maximal oxygen consumption (VO₂ₘₐₓ), peak heart rate (HR) and systolic blood pressure (SBP); ii) PSX at 75% VO₂ₘₐₓ to determine, cardiorespiratory responses, cardiac output (Q), blood lactate [La], free fatty acid [FFA], glucose [G] concentrations and ratings of perceived exertion (RPE), and iii) tests of isometric SMF including maximal voluntary contraction (MVC) and time to fatigue (TTF) during repetitve isometric MVC's. Tests were performed following two week ingestion of amlodipine (5 mg daily) or placebo seperated by a two week washout period. Resting SBP was decreased following ingestion of amlodipine (142 ± 13 vs l33 ± 12 mmHg; vs placebo: [mean± SD]; P<0.05). However, VO₂ₘₐₓ ( 31 ± 5 vs 33 ± 5 mlO₂.kg.min⁻¹ ; amlodipine vs placebo), peak heart rate ( 167 ± 12 vs 165 ± l6b.min⁻¹;amlodipine vs placebo)and peak SBP(l8l ±21 vs 170± 16mmHg; amlodipine vs placebo) were not reduced following ingestion of amlodipine. Submaximal cycling time. VO₂, Q, BP, HR, ventilation, RPE, [FFA], [La] and [G] during PSX were unaltered following ingestion of amlodipine. Similarly ingestion of amlodipine did not alter tests of isometric SMF. These data suggest that: i) ingestion of amlodipine lowers resting SBP but does not alter the normal haemodynamic response during exercise; ii) MAX, PSX exercise performance and SMF are unaltered following ingestion of amlodipine in athletic hypertensive patients. These findings suggest that the regulatory mechanisms which maintain haemodynamic homeostasis during maximal and submaximal exercise are not influenced by ingestion of amlodipine in athletic hypertensive patients.en_ZA
dc.identifier.apacitationGillies, H. C. (1997). <i>The effects of amlodipine on exercise performance in mild to moderate essential hypertensives</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine. Retrieved from http://hdl.handle.net/11427/26977en_ZA
dc.identifier.chicagocitationGillies, Hunter Campbell. <i>"The effects of amlodipine on exercise performance in mild to moderate essential hypertensives."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 1997. http://hdl.handle.net/11427/26977en_ZA
dc.identifier.citationGillies, H. 1997. The effects of amlodipine on exercise performance in mild to moderate essential hypertensives. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Gillies, Hunter Campbell AB - The effect of the long acting dihydropyridine calcium channel antagonist, amlodipine, on the exercise performance of hypertensive patients is not known. The aim of this study was to determine the effects of amlodipine on maximal (MAX), prolonged submaximal (PSX) and on skeletal muscle function (SMF) in patients with mild hypertension. In a double-blind randomised crossover trial, ten physically active hypertensive patients performed i) graded exercise to exhaustion for determination of maximal oxygen consumption (VO₂ₘₐₓ), peak heart rate (HR) and systolic blood pressure (SBP); ii) PSX at 75% VO₂ₘₐₓ to determine, cardiorespiratory responses, cardiac output (Q), blood lactate [La], free fatty acid [FFA], glucose [G] concentrations and ratings of perceived exertion (RPE), and iii) tests of isometric SMF including maximal voluntary contraction (MVC) and time to fatigue (TTF) during repetitve isometric MVC's. Tests were performed following two week ingestion of amlodipine (5 mg daily) or placebo seperated by a two week washout period. Resting SBP was decreased following ingestion of amlodipine (142 ± 13 vs l33 ± 12 mmHg; vs placebo: [mean± SD]; P<0.05). However, VO₂ₘₐₓ ( 31 ± 5 vs 33 ± 5 mlO₂.kg.min⁻¹ ; amlodipine vs placebo), peak heart rate ( 167 ± 12 vs 165 ± l6b.min⁻¹;amlodipine vs placebo)and peak SBP(l8l ±21 vs 170± 16mmHg; amlodipine vs placebo) were not reduced following ingestion of amlodipine. Submaximal cycling time. VO₂, Q, BP, HR, ventilation, RPE, [FFA], [La] and [G] during PSX were unaltered following ingestion of amlodipine. Similarly ingestion of amlodipine did not alter tests of isometric SMF. These data suggest that: i) ingestion of amlodipine lowers resting SBP but does not alter the normal haemodynamic response during exercise; ii) MAX, PSX exercise performance and SMF are unaltered following ingestion of amlodipine in athletic hypertensive patients. These findings suggest that the regulatory mechanisms which maintain haemodynamic homeostasis during maximal and submaximal exercise are not influenced by ingestion of amlodipine in athletic hypertensive patients. DA - 1997 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1997 T1 - The effects of amlodipine on exercise performance in mild to moderate essential hypertensives TI - The effects of amlodipine on exercise performance in mild to moderate essential hypertensives UR - http://hdl.handle.net/11427/26977 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26977
dc.identifier.vancouvercitationGillies HC. The effects of amlodipine on exercise performance in mild to moderate essential hypertensives. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 1997 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26977en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherSports Scienceen_ZA
dc.titleThe effects of amlodipine on exercise performance in mild to moderate essential hypertensivesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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