Impact of the innate environment on maintaining memory T-cell numbers in the female genital tract: implications for mucosal vaccine efficacy?

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dc.contributor.authorDabee, Sen_ZA
dc.contributor.authorPassmore, Jen_ZA
dc.contributor.authorWilliamson, Aen_ZA
dc.contributor.authorGumbi, Pen_ZA
dc.date.accessioned2015-11-18T03:46:59Z
dc.date.available2015-11-18T03:46:59Z
dc.date.issued2012en_ZA
dc.description.abstractPreventative HIV vaccines aim to elicit long-lived protective immune responses at the site of HIV transmission, capable of responding quickly to HIV challenge, but which remain stable at effector sites of the genital mucosa. The genital mucosa is, however, commonly confronted with innate immune modifiers and inflammatory agents including sexually-transmitted infections, behavioural and hygiene practices. We investigated the impact of mucosal inflammation and homeostatic cytokines on local T-cell phenotype, proliferation, exhaustion and activation.en_ZA
dc.identifier.apacitationDabee, S., Passmore, J., Williamson, A., & Gumbi, P. (2012). Impact of the innate environment on maintaining memory T-cell numbers in the female genital tract: implications for mucosal vaccine efficacy?. <i>Retrovirology</i>, http://hdl.handle.net/11427/15046en_ZA
dc.identifier.chicagocitationDabee, S, J Passmore, A Williamson, and P Gumbi "Impact of the innate environment on maintaining memory T-cell numbers in the female genital tract: implications for mucosal vaccine efficacy?." <i>Retrovirology</i> (2012) http://hdl.handle.net/11427/15046en_ZA
dc.identifier.citationDabee, S., Passmore, J., Williamson, A., & Gumbi, P. (2012). Impact of the innate environment on maintaining memory T-cell numbers in the female genital tract: implications for mucosal vaccine efficacy?. Retrovirology, 9(2), 1-1.en_ZA
dc.identifier.ris TY - Journal Article AU - Dabee, S AU - Passmore, J AU - Williamson, A AU - Gumbi, P AB - Preventative HIV vaccines aim to elicit long-lived protective immune responses at the site of HIV transmission, capable of responding quickly to HIV challenge, but which remain stable at effector sites of the genital mucosa. The genital mucosa is, however, commonly confronted with innate immune modifiers and inflammatory agents including sexually-transmitted infections, behavioural and hygiene practices. We investigated the impact of mucosal inflammation and homeostatic cytokines on local T-cell phenotype, proliferation, exhaustion and activation. DA - 2012 DB - OpenUCT DO - 10.1186/1742-4690-9-S2-P193 DP - University of Cape Town J1 - Retrovirology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Impact of the innate environment on maintaining memory T-cell numbers in the female genital tract: implications for mucosal vaccine efficacy? TI - Impact of the innate environment on maintaining memory T-cell numbers in the female genital tract: implications for mucosal vaccine efficacy? UR - http://hdl.handle.net/11427/15046 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15046
dc.identifier.urihttp://dx.doi.org/10.1186/1742-4690-9-S2-P193
dc.identifier.vancouvercitationDabee S, Passmore J, Williamson A, Gumbi P. Impact of the innate environment on maintaining memory T-cell numbers in the female genital tract: implications for mucosal vaccine efficacy?. Retrovirology. 2012; http://hdl.handle.net/11427/15046.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2012 Dabee et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceRetrovirologyen_ZA
dc.source.urihttp://www.retrovirology.com/en_ZA
dc.subject.otherPreventative HIV vaccinesen_ZA
dc.subject.otherimmune responsesen_ZA
dc.titleImpact of the innate environment on maintaining memory T-cell numbers in the female genital tract: implications for mucosal vaccine efficacy?en_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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