Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy
| dc.contributor.advisor | Sliwa, Karen | |
| dc.contributor.author | Masuku, David Sifiso | |
| dc.date.accessioned | 2019-02-19T13:08:02Z | |
| dc.date.available | 2019-02-19T13:08:02Z | |
| dc.date.issued | 2018 | |
| dc.date.updated | 2019-02-19T11:14:51Z | |
| dc.description.abstract | AIM: Subsequent pregnancies (SSPs) in patients with peripartum cardiomyopathy (PPCM) have a high risk of heart failure relapse. We report on outcome of SSPs in PPCM patients in South Africa. METHODS AND RESULTS: Of the 18 PPCM patients with a SSP, 3 patients died within 6-months follow-up. Overall relapse rate, left ventricular ejection fraction (LVEF) <50% or death after at least 6 months follow-up, was 30%, with 16% (3/18) mortality. Persistently reduced LVEF (<50%) before entering SSP was present in 44% of patients, while full recovery (LVEFâ„ 50%) was present in 85%. Persistently reduced LVEF before SSP was associated with a higher mortality (27% vs 0%) and a lower rate of full recovery at follow-up. Patients obtaining standard therapy for heart failure and bromocriptine immediately after delivery displayed significantly better LVEF at follow-up and a higher rate of full recovery, with no patient dying, compared with patients obtaining standard therapy for heart failure alone. CONCLUSION: Full recovery of LVEF before SSP was associated with lower mortality and better cardiac function at follow-up. Addition of bromocriptine to standard therapy for heart failure immediately after delivery was safe and appeared to be associated with better outcome of SSP in our patients. | |
| dc.identifier.apacitation | Masuku, D. S. (2018). <i>Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy</i>. (). University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology. Retrieved from http://hdl.handle.net/11427/29669 | en_ZA |
| dc.identifier.chicagocitation | Masuku, David Sifiso. <i>"Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy."</i> ., University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2018. http://hdl.handle.net/11427/29669 | en_ZA |
| dc.identifier.citation | Masuku, D. 2018. Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy. University of Cape Town. | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Masuku, David Sifiso AB - AIM: Subsequent pregnancies (SSPs) in patients with peripartum cardiomyopathy (PPCM) have a high risk of heart failure relapse. We report on outcome of SSPs in PPCM patients in South Africa. METHODS AND RESULTS: Of the 18 PPCM patients with a SSP, 3 patients died within 6-months follow-up. Overall relapse rate, left ventricular ejection fraction (LVEF) <50% or death after at least 6 months follow-up, was 30%, with 16% (3/18) mortality. Persistently reduced LVEF (<50%) before entering SSP was present in 44% of patients, while full recovery (LVEFâ„ 50%) was present in 85%. Persistently reduced LVEF before SSP was associated with a higher mortality (27% vs 0%) and a lower rate of full recovery at follow-up. Patients obtaining standard therapy for heart failure and bromocriptine immediately after delivery displayed significantly better LVEF at follow-up and a higher rate of full recovery, with no patient dying, compared with patients obtaining standard therapy for heart failure alone. CONCLUSION: Full recovery of LVEF before SSP was associated with lower mortality and better cardiac function at follow-up. Addition of bromocriptine to standard therapy for heart failure immediately after delivery was safe and appeared to be associated with better outcome of SSP in our patients. DA - 2018 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2018 T1 - Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy TI - Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy UR - http://hdl.handle.net/11427/29669 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/29669 | |
| dc.identifier.vancouvercitation | Masuku DS. Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy. []. University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2018 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/29669 | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | Division of Cardiology | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.publisher.institution | University of Cape Town | |
| dc.subject.other | Peripartum Cardiomyopathy | |
| dc.title | Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy | |
| dc.type | Master Thesis | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationname | MMed |