Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (Rutherford Clinical Category 4-6)

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dc.contributor.advisorNaidoo, Nadraj Gen_ZA
dc.contributor.authorMotsumi, Mpaphoen_ZA
dc.date.accessioned2016-07-28T12:21:37Z
dc.date.available2016-07-28T12:21:37Z
dc.date.issued2016en_ZA
dc.description.abstractBackground: The literature tends to support the notion that diabetic patients typically suffer from tibio-peroneal artery occlusive disease (1) (2) (11) (5) (10) (8) with relative sparing of the foot arteries (1). This study seeks to investigate the pattern and distribution of peripheral artery occlusive disease and the arterial foot arch status in diabetic patients with critical limb ischaemia Methods: This is a one year prospective study -(January 2014 to December 2014) carried out on consecutive patients seen at Groote Schuur Hospital, Vascular Department. The inclusion criteria is: diabetic patients ≥18 years of age with critical limb ischemia who had pre- and post-intervention vascular imaging. The calculated minimum sample size of 63 limbs [756 patency levels (63x12)] was needed to achieve a power of 86% to detect a difference of 0.1900 (19%) with a target significance level of 0.05 (using PASS 11 software). The equality of distribution of categories was analyzed using the One sample Chi-square test (SPSS 22) with our Null hypothesis (N0) assuming that categories occur with equal proportions. In this case categories refers to the 5 patency levels used in this study. All 12 main arteries from infra-renal aorta to crural arteries had their patency levels graded from category 1 to category 5 (widely patent to occluded). The findings were then stratified according to gender, age group ( <40 years, 40-54 years and ≥ 55 years) and risk factor combinations [ Group1 = (DM, HPT, Dyslipidemia); Group 2= (DM, HPT, dyslipidemia, exsmoker); Group 3 = (DM, HPT, dyslipidemia, smoker)]. The three risk combination groups formed the majority of our study group (79%).en_ZA
dc.identifier.apacitationMotsumi, M. (2016). <i>Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (Rutherford Clinical Category 4-6)</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Surgery. Retrieved from http://hdl.handle.net/11427/20964en_ZA
dc.identifier.chicagocitationMotsumi, Mpapho. <i>"Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (Rutherford Clinical Category 4-6)."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Surgery, 2016. http://hdl.handle.net/11427/20964en_ZA
dc.identifier.citationMotsumi, M. 2016. Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (Rutherford Clinical Category 4-6). University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Motsumi, Mpapho AB - Background: The literature tends to support the notion that diabetic patients typically suffer from tibio-peroneal artery occlusive disease (1) (2) (11) (5) (10) (8) with relative sparing of the foot arteries (1). This study seeks to investigate the pattern and distribution of peripheral artery occlusive disease and the arterial foot arch status in diabetic patients with critical limb ischaemia Methods: This is a one year prospective study -(January 2014 to December 2014) carried out on consecutive patients seen at Groote Schuur Hospital, Vascular Department. The inclusion criteria is: diabetic patients ≥18 years of age with critical limb ischemia who had pre- and post-intervention vascular imaging. The calculated minimum sample size of 63 limbs [756 patency levels (63x12)] was needed to achieve a power of 86% to detect a difference of 0.1900 (19%) with a target significance level of 0.05 (using PASS 11 software). The equality of distribution of categories was analyzed using the One sample Chi-square test (SPSS 22) with our Null hypothesis (N0) assuming that categories occur with equal proportions. In this case categories refers to the 5 patency levels used in this study. All 12 main arteries from infra-renal aorta to crural arteries had their patency levels graded from category 1 to category 5 (widely patent to occluded). The findings were then stratified according to gender, age group ( <40 years, 40-54 years and ≥ 55 years) and risk factor combinations [ Group1 = (DM, HPT, Dyslipidemia); Group 2= (DM, HPT, dyslipidemia, exsmoker); Group 3 = (DM, HPT, dyslipidemia, smoker)]. The three risk combination groups formed the majority of our study group (79%). DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (Rutherford Clinical Category 4-6) TI - Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (Rutherford Clinical Category 4-6) UR - http://hdl.handle.net/11427/20964 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20964
dc.identifier.vancouvercitationMotsumi M. Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (Rutherford Clinical Category 4-6). [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Surgery, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20964en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Surgeryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherSurgeryen_ZA
dc.titlePattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (Rutherford Clinical Category 4-6)en_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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