Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents
| dc.contributor.author | Mbaba, Mziyanda | |
| dc.contributor.author | Golding, Taryn M | |
| dc.contributor.author | Smith, Gregory S | |
| dc.date.accessioned | 2021-10-12T13:54:25Z | |
| dc.date.available | 2021-10-12T13:54:25Z | |
| dc.date.issued | 2020-11-12 | |
| dc.date.updated | 2020-11-26T14:09:05Z | |
| dc.description.abstract | In the face of the recent pandemic and emergence of infectious diseases of viral origin, research on parasitic diseases such as malaria continues to remain critical and innovative methods are required to target the rising widespread resistance that renders conventional therapies unusable. The prolific use of auxiliary metallo-fragments has augmented the search for novel drug regimens in an attempt to combat rising resistance. The development of organometallic compounds (those containing metal-carbon bonds) as antimalarial drugs has been exemplified by the clinical development of ferroquine in the nascent field of Bioorganometallic Chemistry. With their inherent physicochemical properties, organometallic complexes can modulate the discipline of chemical biology by proffering different modes of action and targeting various enzymes. With the beneficiation of platinum group metals (PGMs) in mind, this review aims to describe recent studies on the antimalarial activity of PGM-based organometallic complexes. This review does not provide an exhaustive coverage of the literature but focusses on recent advances of bioorganometallic antimalarial drug leads, including a brief mention of recent trends comprising interactions with biomolecules such as heme and intracellular catalysis. This resource can be used in parallel with complementary reviews on metal-based complexes tested against malaria. | en_US |
| dc.identifier | doi: 10.3390/molecules25225276 | |
| dc.identifier.apacitation | Mbaba, M., Golding, T. M., & Smith, G. S. (2020). Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents. <i>Molecules</i>, 25(22), http://hdl.handle.net/11427/35210 | en_ZA |
| dc.identifier.chicagocitation | Mbaba, Mziyanda, Taryn M Golding, and Gregory S Smith "Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents." <i>Molecules</i> 25, 22. (2020) http://hdl.handle.net/11427/35210 | en_ZA |
| dc.identifier.citation | Mbaba, M., Golding, T.M. & Smith, G.S. 2020. Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents. <i>Molecules.</i> 25(22) http://hdl.handle.net/11427/35210 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Mbaba, Mziyanda AU - Golding, Taryn M AU - Smith, Gregory S AB - In the face of the recent pandemic and emergence of infectious diseases of viral origin, research on parasitic diseases such as malaria continues to remain critical and innovative methods are required to target the rising widespread resistance that renders conventional therapies unusable. The prolific use of auxiliary metallo-fragments has augmented the search for novel drug regimens in an attempt to combat rising resistance. The development of organometallic compounds (those containing metal-carbon bonds) as antimalarial drugs has been exemplified by the clinical development of ferroquine in the nascent field of Bioorganometallic Chemistry. With their inherent physicochemical properties, organometallic complexes can modulate the discipline of chemical biology by proffering different modes of action and targeting various enzymes. With the beneficiation of platinum group metals (PGMs) in mind, this review aims to describe recent studies on the antimalarial activity of PGM-based organometallic complexes. This review does not provide an exhaustive coverage of the literature but focusses on recent advances of bioorganometallic antimalarial drug leads, including a brief mention of recent trends comprising interactions with biomolecules such as heme and intracellular catalysis. This resource can be used in parallel with complementary reviews on metal-based complexes tested against malaria. DA - 2020-11-12 DB - OpenUCT DP - University of Cape Town IS - 22 J1 - Molecules LK - https://open.uct.ac.za PY - 2020 T1 - Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents TI - Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents UR - http://hdl.handle.net/11427/35210 ER - | en_ZA |
| dc.identifier.uri | https://doi.org/10.3390/molecules25225276 | |
| dc.identifier.uri | http://hdl.handle.net/11427/35210 | |
| dc.identifier.vancouvercitation | Mbaba M, Golding TM, Smith GS. Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents. Molecules. 2020;25(22) http://hdl.handle.net/11427/35210. | en_ZA |
| dc.language.iso | en | en_US |
| dc.publisher.department | Department of Chemistry | en_US |
| dc.publisher.faculty | Faculty of Science | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.source | Molecules | en_US |
| dc.source.journalissue | 22 | en_US |
| dc.source.journalvolume | 25 | en_US |
| dc.source.uri | https://www.mdpi.com/journal/molecules | |
| dc.title | Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents | en_US |
| dc.type | Journal Article | en_US |