Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection

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dc.contributor.authorAllie, Nasiema
dc.contributor.authorGrivennikov, Sergei I
dc.contributor.authorKeeton, Roanne
dc.contributor.authorHsu, Nai-Jen
dc.contributor.authorBourigault, Marie-Laure
dc.contributor.authorCourt, Nathalie
dc.contributor.authorFremond, Cecile
dc.contributor.authorYeremeev, Vladimir
dc.contributor.authorShebzukhov, Yuriy
dc.contributor.authorRyffel, Bernhard
dc.contributor.authorNedospasov, Sergei A
dc.contributor.authorQuesniaux, Valérie F J
dc.contributor.authorJacobs, Muazzam
dc.date.accessioned2021-10-08T07:16:02Z
dc.date.available2021-10-08T07:16:02Z
dc.date.issued2013
dc.description.abstractTumour Necrosis Factor (TNF) is critical for host control of M. tuberculosis, but the relative contribution of TNF from innate and adaptive immune responses during tuberculosis infection is unclear. Myeloid versus T-cell-derived TNF function in tuberculosis was investigated using cell type-specific TNF deletion. Mice deficient for TNF expression in macrophages/neutrophils displayed early, transient susceptibility to M. tuberculosis but recruited activated, TNF-producing CD4+ and CD8+ T-cells and controlled chronic infection. Strikingly, deficient TNF expression in T-cells resulted in early control but susceptibility and eventual mortality during chronic infection with increased pulmonary pathology. TNF inactivation in both myeloid and T-cells rendered mice critically susceptible to infection with a phenotype resembling complete TNF deficient mice, indicating that myeloid and T-cells are the primary TNF sources collaborating for host control of tuberculosis. Thus, while TNF from myeloid cells mediates early immune function, T-cell derived TNF is essential to sustain protection during chronic tuberculosis infection.
dc.identifier.apacitationAllie, N., , Keeton, R., Hsu, N., Bourigault, M., Court, N., ... Jacobs, M. (2013). Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection. <i>Scientific Reports</i>, 3(1), 174 - 177. http://hdl.handle.net/11427/34751en_ZA
dc.identifier.chicagocitationAllie, Nasiema, , Roanne Keeton, Nai-Jen Hsu, Marie-Laure Bourigault, Nathalie Court, Cecile Fremond, et al "Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection." <i>Scientific Reports</i> 3, 1. (2013): 174 - 177. http://hdl.handle.net/11427/34751en_ZA
dc.identifier.citationAllie, N., , Keeton, R., Hsu, N., Bourigault, M., Court, N., Fremond, C. & Yeremeev, V. et al. 2013. Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection. <i>Scientific Reports.</i> 3(1):174 - 177. http://hdl.handle.net/11427/34751en_ZA
dc.identifier.issn2045-2322
dc.identifier.ris TY - Journal Article AU - Allie, Nasiema AU - Grivennikov, Sergei I AU - Keeton, Roanne AU - Hsu, Nai-Jen AU - Bourigault, Marie-Laure AU - Court, Nathalie AU - Fremond, Cecile AU - Yeremeev, Vladimir AU - Shebzukhov, Yuriy AU - Ryffel, Bernhard AU - Nedospasov, Sergei A AU - Quesniaux, Valérie F J AU - Jacobs, Muazzam AB - Tumour Necrosis Factor (TNF) is critical for host control of M. tuberculosis, but the relative contribution of TNF from innate and adaptive immune responses during tuberculosis infection is unclear. Myeloid versus T-cell-derived TNF function in tuberculosis was investigated using cell type-specific TNF deletion. Mice deficient for TNF expression in macrophages/neutrophils displayed early, transient susceptibility to M. tuberculosis but recruited activated, TNF-producing CD4+ and CD8+ T-cells and controlled chronic infection. Strikingly, deficient TNF expression in T-cells resulted in early control but susceptibility and eventual mortality during chronic infection with increased pulmonary pathology. TNF inactivation in both myeloid and T-cells rendered mice critically susceptible to infection with a phenotype resembling complete TNF deficient mice, indicating that myeloid and T-cells are the primary TNF sources collaborating for host control of tuberculosis. Thus, while TNF from myeloid cells mediates early immune function, T-cell derived TNF is essential to sustain protection during chronic tuberculosis infection. DA - 2013 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Scientific Reports LK - https://open.uct.ac.za PY - 2013 SM - 2045-2322 T1 - Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection TI - Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection UR - http://hdl.handle.net/11427/34751 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34751
dc.identifier.vancouvercitationAllie N, , Keeton R, Hsu N, Bourigault M, Court N, et al. Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection. Scientific Reports. 2013;3(1):174 - 177. http://hdl.handle.net/11427/34751.en_ZA
dc.language.isoeng
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceScientific Reports
dc.source.journalissue1
dc.source.journalvolume3
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1038/srep01809
dc.subject.otherAnimals
dc.subject.otherBlotting, Western
dc.subject.otherCD8-Positive T-Lymphocytes
dc.subject.otherCell Differentiation
dc.subject.otherCell Proliferation
dc.subject.otherCells, Cultured
dc.subject.otherFlow Cytometry
dc.subject.otherIntegrases
dc.subject.otherLung
dc.subject.otherMacrophages
dc.subject.otherMice
dc.subject.otherMice, Knockout
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherMyeloid Cells
dc.titleProminent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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