Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women

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dc.contributor.authorNaranbhai, V
dc.contributor.authorde Assis Rosa, D
dc.contributor.authorWerner, L
dc.contributor.authorMoodley, R
dc.contributor.authorHong, H
dc.contributor.authorKharsany, A
dc.contributor.authorMlisana, K
dc.contributor.authorSibeko, S
dc.contributor.authorGarrett, N
dc.contributor.authorChopera, D
dc.contributor.authorCarr, W H
dc.contributor.authorAbdool Karim, Q
dc.contributor.authorHill, A V S
dc.contributor.authorAbdool Karim, S S
dc.contributor.authorAltfeld, M
dc.contributor.authorGray, C M
dc.contributor.authorNdung’u, T
dc.date.accessioned2016-05-19T13:20:29Z
dc.date.available2016-05-19T13:20:29Z
dc.date.issued2016-01-25
dc.date.updated2016-05-18T15:42:04Z
dc.description.abstractBackground: Killer-cell Immunoglobulin-like Receptors (KIR) interact with Human Leukocyte Antigen(HLA) to modify natural killer- and T-cell function. KIR are implicated in HIV acquisition by small studies that have not been widely replicated. A role for KIR in HIV disease progression is more widely replicated and supported by functional studies. Methods: To assess the role of KIR and KIR ligands in HIV acquisition and disease course, we studied at-risk women in South Africa between 2004–2010. Logistic regression was used for nested case–control analysis of 154 women who acquired vs. 155 who did not acquire HIV, despite high exposure. Linear mixed-effects models were used for cohort analysis of 139 women followed prospectively for a median of 54 months (IQR 31–69) until 2014. Results: Neither KIR repertoires nor HLA alleles were associated with HIV acquisition. However, KIR haplotype BB was associated with lower viral loads (−0.44log10 copies/ml;SE = 0.18;p = 0.03) and higher CD4+ T-cell counts(+80 cells/ μl;SE = 42;p = 0.04). This was largely explained by the protective effect of KIR2DL2/KIR2DS2 on the B haplotype and reciprocal detrimental effect of KIR2DL3 on the A haplotype. Conclusions: Although neither KIR nor HLA appear to have a role in HIV acquisition, our data are consistent with involvement of KIR2DL2 in HIV control. Additional studies to replicate these findings are indicateden_ZA
dc.identifier10.1186/s12879-016-1361-1
dc.identifier.apacitationNaranbhai, V., de Assis Rosa, D., Werner, L., Moodley, R., Hong, H., Kharsany, A., ... (2016). Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women. <i>BMC Infectious Diseases</i>, http://hdl.handle.net/11427/19724en_ZA
dc.identifier.chicagocitationNaranbhai, V, D de Assis Rosa, L Werner, R Moodley, H Hong, A Kharsany, K Mlisana, et al "Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women." <i>BMC Infectious Diseases</i> (2016) http://hdl.handle.net/11427/19724en_ZA
dc.identifier.citationNaranbhai, V., de Assis Rosa, D., Werner, L., Moodley, R., Hong, H., Kharsany, A., ... & Carr, W. H. (2016). Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women. BMC infectious diseases, 16(1), 1.en_ZA
dc.identifier.issn1471-2334en_ZA
dc.identifier.ris TY - Journal Article AU - Naranbhai, V AU - de Assis Rosa, D AU - Werner, L AU - Moodley, R AU - Hong, H AU - Kharsany, A AU - Mlisana, K AU - Sibeko, S AU - Garrett, N AU - Chopera, D AU - Carr, W H AU - Abdool Karim, Q AU - Hill, A V S AU - Abdool Karim, S S AU - Altfeld, M AU - Gray, C M AU - Ndung’u, T AB - Background: Killer-cell Immunoglobulin-like Receptors (KIR) interact with Human Leukocyte Antigen(HLA) to modify natural killer- and T-cell function. KIR are implicated in HIV acquisition by small studies that have not been widely replicated. A role for KIR in HIV disease progression is more widely replicated and supported by functional studies. Methods: To assess the role of KIR and KIR ligands in HIV acquisition and disease course, we studied at-risk women in South Africa between 2004–2010. Logistic regression was used for nested case–control analysis of 154 women who acquired vs. 155 who did not acquire HIV, despite high exposure. Linear mixed-effects models were used for cohort analysis of 139 women followed prospectively for a median of 54 months (IQR 31–69) until 2014. Results: Neither KIR repertoires nor HLA alleles were associated with HIV acquisition. However, KIR haplotype BB was associated with lower viral loads (−0.44log10 copies/ml;SE = 0.18;p = 0.03) and higher CD4+ T-cell counts(+80 cells/ μl;SE = 42;p = 0.04). This was largely explained by the protective effect of KIR2DL2/KIR2DS2 on the B haplotype and reciprocal detrimental effect of KIR2DL3 on the A haplotype. Conclusions: Although neither KIR nor HLA appear to have a role in HIV acquisition, our data are consistent with involvement of KIR2DL2 in HIV control. Additional studies to replicate these findings are indicated DA - 2016-01-25 DB - OpenUCT DO - 10.1186/s12879-016-1361-1 DP - University of Cape Town J1 - BMC Infectious Diseases LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 SM - 1471-2334 T1 - Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women TI - Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women UR - http://hdl.handle.net/11427/19724 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12879-016-1361-1
dc.identifier.urihttp://hdl.handle.net/11427/19724
dc.identifier.urihttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1361-1
dc.identifier.vancouvercitationNaranbhai V, de Assis Rosa D, Werner L, Moodley R, Hong H, Kharsany A, et al. Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women. BMC Infectious Diseases. 2016; http://hdl.handle.net/11427/19724.en_ZA
dc.languageengen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.holderNaranbhai et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceBMC Infectious Diseasesen_ZA
dc.source.urihttp://bmcinfectdis.biomedcentral.com/
dc.titleKiller-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African womenen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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