Current trends in drug treatment of obsessive–compulsive disorder

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dc.contributor.authorDecloedt, Eric
dc.date.accessioned2021-10-08T07:08:27Z
dc.date.available2021-10-08T07:08:27Z
dc.date.issued2010
dc.description.abstractThis article aims to highlight current trends in the pharmacologic management of obsessive–compulsive disorder (OCD). A systematic search of the electronic database MEDLINE was conducted. The first case report of clomipramine efficacy in the management OCD more than 40 years ago gave new hope for the treatment of this debilitating disorder. Selective serotonin reuptake inhibitors (SSRIs) proved to have a similar efficacy profile compared with clomipramine but had a superior tolerability profile. While many patients with OCD respond to SSRIs or clomipramine, the treatment of those with refractory OCD remains challenging. Different augmentation agents in treatment-resistant OCD have been explored, with antipsychotic agents having the largest supporting evidence base. Nevertheless, new pharmacologic treatment options are required and are under investigation.
dc.identifier.apacitationDecloedt, E. (2010). Current trends in drug treatment of obsessive–compulsive disorder. <i>Neuropsychiatric Disease and Treatment</i>, 6(4), 174 - 177. http://hdl.handle.net/11427/34583en_ZA
dc.identifier.chicagocitationDecloedt, Eric "Current trends in drug treatment of obsessive–compulsive disorder." <i>Neuropsychiatric Disease and Treatment</i> 6, 4. (2010): 174 - 177. http://hdl.handle.net/11427/34583en_ZA
dc.identifier.citationDecloedt, E. 2010. Current trends in drug treatment of obsessive–compulsive disorder. <i>Neuropsychiatric Disease and Treatment.</i> 6(4):174 - 177. http://hdl.handle.net/11427/34583en_ZA
dc.identifier.issn1176-6328
dc.identifier.issn1178-2021
dc.identifier.ris TY - Journal Article AU - Decloedt, Eric AB - This article aims to highlight current trends in the pharmacologic management of obsessive–compulsive disorder (OCD). A systematic search of the electronic database MEDLINE was conducted. The first case report of clomipramine efficacy in the management OCD more than 40 years ago gave new hope for the treatment of this debilitating disorder. Selective serotonin reuptake inhibitors (SSRIs) proved to have a similar efficacy profile compared with clomipramine but had a superior tolerability profile. While many patients with OCD respond to SSRIs or clomipramine, the treatment of those with refractory OCD remains challenging. Different augmentation agents in treatment-resistant OCD have been explored, with antipsychotic agents having the largest supporting evidence base. Nevertheless, new pharmacologic treatment options are required and are under investigation. DA - 2010 DB - OpenUCT DP - University of Cape Town IS - 4 J1 - Neuropsychiatric Disease and Treatment LK - https://open.uct.ac.za PY - 2010 SM - 1176-6328 SM - 1178-2021 T1 - Current trends in drug treatment of obsessive–compulsive disorder TI - Current trends in drug treatment of obsessive–compulsive disorder UR - http://hdl.handle.net/11427/34583 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34583
dc.identifier.vancouvercitationDecloedt E. Current trends in drug treatment of obsessive–compulsive disorder. Neuropsychiatric Disease and Treatment. 2010;6(4):174 - 177. http://hdl.handle.net/11427/34583.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Psychiatry and Mental Health
dc.publisher.facultyFaculty of Health Sciences
dc.sourceNeuropsychiatric Disease and Treatment
dc.source.journalissue4
dc.source.journalvolume6
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.2147/NDT.S3149
dc.subject.otherobsessive–compulsive disorder
dc.subject.otherpharmacology
dc.subject.othertreatment
dc.subject.otherdrug
dc.titleCurrent trends in drug treatment of obsessive–compulsive disorder
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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