A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga

Simple item page
dc.contributor.advisorBarnes, Karen Ien_ZA
dc.contributor.advisorFolb, Peter Ien_ZA
dc.contributor.authorWilkins, Justinen_ZA
dc.date.accessioned2018-01-09T08:57:37Z
dc.date.available2018-01-09T08:57:37Z
dc.date.issued1999en_ZA
dc.description.abstractFollowing the completion of a detailed baseline study of malaria in the region, a model was developed to assess the cost-effectiveness of switching from chloroquine to sulfadoxine-pyrimetharnine as first line treatment in the Tonga district of Mpumalanga, South Africa, where malaria is seasonal and the population is non-immune. In vivo drug resistance was used to create a resistance variable, which was used to assess the 1997 relative costs to the health care system of employing the two drugs, analysing factors such as drug costs, staff time, transport costs, maintenance costs, utility costs, training costs and consumables costs to generate an average cost-effectiveness ratio. The model was subsequently used to estimate the average cost-effectiveness ratios of nine other potential agents for the treatment of first line malaria, including artesunate monotherapy, artesunate combinations, pyronaridine, atovaquone-proguanil, co-artemether, halofantrine, amodiaquine, and mefloquine. It was found that sulfadoxinepyrimethamine was 5 times more cost-effective as first line therapy than chloroquine. Of the other modelled drugs, it was recommended that an artesunate combination should be implemented when it becomes necessary to replace sulfadoxine-pyrimethamine; artesunate-mefloquine and artesunate-SP were estimated to be 6 times and 9 times as cost-effective as chloroquine, respectively.en_ZA
dc.identifier.apacitationWilkins, J. (1999). <i>A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/26763en_ZA
dc.identifier.chicagocitationWilkins, Justin. <i>"A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 1999. http://hdl.handle.net/11427/26763en_ZA
dc.identifier.citationWilkins, J. 1999. A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Wilkins, Justin AB - Following the completion of a detailed baseline study of malaria in the region, a model was developed to assess the cost-effectiveness of switching from chloroquine to sulfadoxine-pyrimetharnine as first line treatment in the Tonga district of Mpumalanga, South Africa, where malaria is seasonal and the population is non-immune. In vivo drug resistance was used to create a resistance variable, which was used to assess the 1997 relative costs to the health care system of employing the two drugs, analysing factors such as drug costs, staff time, transport costs, maintenance costs, utility costs, training costs and consumables costs to generate an average cost-effectiveness ratio. The model was subsequently used to estimate the average cost-effectiveness ratios of nine other potential agents for the treatment of first line malaria, including artesunate monotherapy, artesunate combinations, pyronaridine, atovaquone-proguanil, co-artemether, halofantrine, amodiaquine, and mefloquine. It was found that sulfadoxinepyrimethamine was 5 times more cost-effective as first line therapy than chloroquine. Of the other modelled drugs, it was recommended that an artesunate combination should be implemented when it becomes necessary to replace sulfadoxine-pyrimethamine; artesunate-mefloquine and artesunate-SP were estimated to be 6 times and 9 times as cost-effective as chloroquine, respectively. DA - 1999 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1999 T1 - A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga TI - A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga UR - http://hdl.handle.net/11427/26763 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26763
dc.identifier.vancouvercitationWilkins J. A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 1999 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26763en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPharmacologyen_ZA
dc.titleA cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalangaen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_1999_wilkins_justin.pdf
Size:
16.76 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters