Anaemia in acute HIV-1 subtype C infection

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dc.contributor.authorMlisana, Kolekaen_ZA
dc.contributor.authorAuld, Sara Cen_ZA
dc.contributor.authorGrobler, Annekeen_ZA
dc.contributor.authorLoggerenberg, Francois vanen_ZA
dc.contributor.authorWilliamson, Carolynen_ZA
dc.contributor.authorIriogbe, Ituaen_ZA
dc.contributor.authorSobieszczyk, Magdalena Een_ZA
dc.contributor.authorKarim, Salim S Abdoolen_ZA
dc.contributor.authorTeam, for the CAPRISA Acute Infection Studyen_ZA
dc.date.accessioned2015-12-28T06:47:29Z
dc.date.available2015-12-28T06:47:29Z
dc.date.issued2008en_ZA
dc.description.abstractBACKGROUND: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute and early HIV-1 infection. METHODS: HIV-negative women (n = 245) were enrolled into an observational cohort as part of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) Acute Infection Study. Acute infection was diagnosed following a positive HIV RNA PCR in the absence of antibodies, or detection of HIV-1 antibodies within 3 months of a previously negative antibody test. Haemotologic parameters were assessed before infection and at regular intervals in the first twelve months of HIV infection. RESULTS: Fifty-seven participants with acute HIV infection were identified at a median of 14.5 days post-infection (range 10-81) and were enrolled in the CAPRISA Acute Infection cohort at a median of 41 days post-infection (range 15-104). Mean haemoglobin prior to HIV-1 infection was 12.7 g/dL, with a mean decline of 0.46 g/dL following infection. The prevalence of anaemia increased from 25.0% prior to HIV-1 infection to 52.6% at 3 months post-infection, 61.1% at 6 months post-infection, and 51.4% at 12 months post-infection. CONCLUSIONS: Haematologic derangements and anaemia with a trend towards iron deficiency are common with acute HIV-1 subtype C infection in this small cohort. The negative impact of anaemia concurrent with established HIV infection upon morbidity and mortality has been well documented but the prognostic potential and long-term effects of anaemia during acute HIV-1 infection remain unknown.en_ZA
dc.identifier.apacitationMlisana, K., Auld, S. C., Grobler, A., Loggerenberg, F. v., Williamson, C., Iriogbe, I., ... Team, f. t. C. A. I. S. (2008). Anaemia in acute HIV-1 subtype C infection. <i>PLoS One</i>, http://hdl.handle.net/11427/16029en_ZA
dc.identifier.chicagocitationMlisana, Koleka, Sara C Auld, Anneke Grobler, Francois van Loggerenberg, Carolyn Williamson, Itua Iriogbe, Magdalena E Sobieszczyk, Salim S Abdool Karim, and for the CAPRISA Acute Infection Study Team "Anaemia in acute HIV-1 subtype C infection." <i>PLoS One</i> (2008) http://hdl.handle.net/11427/16029en_ZA
dc.identifier.citationMlisana, K., Auld, S. C., Grobler, A., Van Loggerenberg, F., Williamson, C., Iriogbe, I., ... & Karim, S. A. (2008). Anaemia in acute HIV-1 subtype C infection. PloS one, 3(2), e1626. doi:10.1371/journal.pone.0001626en_ZA
dc.identifier.ris TY - Journal Article AU - Mlisana, Koleka AU - Auld, Sara C AU - Grobler, Anneke AU - Loggerenberg, Francois van AU - Williamson, Carolyn AU - Iriogbe, Itua AU - Sobieszczyk, Magdalena E AU - Karim, Salim S Abdool AU - Team, for the CAPRISA Acute Infection Study AB - BACKGROUND: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute and early HIV-1 infection. METHODS: HIV-negative women (n = 245) were enrolled into an observational cohort as part of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) Acute Infection Study. Acute infection was diagnosed following a positive HIV RNA PCR in the absence of antibodies, or detection of HIV-1 antibodies within 3 months of a previously negative antibody test. Haemotologic parameters were assessed before infection and at regular intervals in the first twelve months of HIV infection. RESULTS: Fifty-seven participants with acute HIV infection were identified at a median of 14.5 days post-infection (range 10-81) and were enrolled in the CAPRISA Acute Infection cohort at a median of 41 days post-infection (range 15-104). Mean haemoglobin prior to HIV-1 infection was 12.7 g/dL, with a mean decline of 0.46 g/dL following infection. The prevalence of anaemia increased from 25.0% prior to HIV-1 infection to 52.6% at 3 months post-infection, 61.1% at 6 months post-infection, and 51.4% at 12 months post-infection. CONCLUSIONS: Haematologic derangements and anaemia with a trend towards iron deficiency are common with acute HIV-1 subtype C infection in this small cohort. The negative impact of anaemia concurrent with established HIV infection upon morbidity and mortality has been well documented but the prognostic potential and long-term effects of anaemia during acute HIV-1 infection remain unknown. DA - 2008 DB - OpenUCT DO - 10.1371/journal.pone.0001626 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Anaemia in acute HIV-1 subtype C infection TI - Anaemia in acute HIV-1 subtype C infection UR - http://hdl.handle.net/11427/16029 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16029
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0001626
dc.identifier.vancouvercitationMlisana K, Auld SC, Grobler A, Loggerenberg Fv, Williamson C, Iriogbe I, et al. Anaemia in acute HIV-1 subtype C infection. PLoS One. 2008; http://hdl.handle.net/11427/16029.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2008 Mlisana et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherAnemiaen_ZA
dc.subject.otherHIV-1en_ZA
dc.subject.otherHIV infectionsen_ZA
dc.subject.otherAntibodiesen_ZA
dc.subject.otherViral loaden_ZA
dc.subject.otherEnzyme-linked immunoassaysen_ZA
dc.subject.otherFerritinen_ZA
dc.subject.otherAIDSen_ZA
dc.titleAnaemia in acute HIV-1 subtype C infectionen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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