Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner

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dc.contributor.authorSaleh, Muhammad G
dc.contributor.authorSharp, Sarah-Kate
dc.contributor.authorAlhamud, Alkathafi
dc.contributor.authorSpottiswoode, Bruce S
dc.contributor.authorvan der Kouwe, André J W
dc.contributor.authorDavies, Neil H
dc.contributor.authorFranz, Thomas
dc.contributor.authorMeintjes, Ernesta M
dc.date.accessioned2021-10-08T07:04:25Z
dc.date.available2021-10-08T07:04:25Z
dc.date.issued2012
dc.description.abstractPurpose. To evaluate whether 3T clinical MRI with a small-animal coil and gradient-echo (GE) sequence could be used to characterize long-term left ventricular remodelling (LVR) following nonreperfused myocardial infarction (MI) using semi-automatic segmentation software (SASS) in a rat model. Materials and Methods. 5 healthy rats were used to validate left ventricular mass (LVM) measured by MRI with postmortem values. 5 sham and 7 infarcted rats were scanned at 2 and 4 weeks after surgery to allow for functional and structural analysis of the heart. Measurements included ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and LVM. Changes in different regions of the heart were quantified using wall thickness analyses. Results. LVM validation in healthy rats demonstrated high correlation between MR and postmortem values. Functional assessment at 4 weeks after MI revealed considerable reduction in EF, increases in ESV, EDV, and LVM, and contractile dysfunction in infarcted and noninfarcted regions. Conclusion. Clinical 3T MRI with a small animal coil and GE sequence generated images in a rat heart with adequate signal-to-noise ratio (SNR) for successful semiautomatic segmentation to accurately and rapidly evaluate long-term LVR after MI.
dc.identifier.apacitationSaleh, M. G., Sharp, S., Alhamud, A., Spottiswoode, B. S., van der Kouwe, A. J. W., Davies, N. H., ... Meintjes, E. M. (2012). Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner. <i>Journal of Biomedicine and Biotechnology</i>, 2012(4), 174 - 177. http://hdl.handle.net/11427/34501en_ZA
dc.identifier.chicagocitationSaleh, Muhammad G, Sarah-Kate Sharp, Alkathafi Alhamud, Bruce S Spottiswoode, André J W van der Kouwe, Neil H Davies, Thomas Franz, and Ernesta M Meintjes "Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner." <i>Journal of Biomedicine and Biotechnology</i> 2012, 4. (2012): 174 - 177. http://hdl.handle.net/11427/34501en_ZA
dc.identifier.citationSaleh, M.G., Sharp, S., Alhamud, A., Spottiswoode, B.S., van der Kouwe, A.J.W., Davies, N.H., Franz, T. & Meintjes, E.M. et al. 2012. Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner. <i>Journal of Biomedicine and Biotechnology.</i> 2012(4):174 - 177. http://hdl.handle.net/11427/34501en_ZA
dc.identifier.issn1110-7243
dc.identifier.issn1110-7251
dc.identifier.ris TY - Journal Article AU - Saleh, Muhammad G AU - Sharp, Sarah-Kate AU - Alhamud, Alkathafi AU - Spottiswoode, Bruce S AU - van der Kouwe, André J W AU - Davies, Neil H AU - Franz, Thomas AU - Meintjes, Ernesta M AB - Purpose. To evaluate whether 3T clinical MRI with a small-animal coil and gradient-echo (GE) sequence could be used to characterize long-term left ventricular remodelling (LVR) following nonreperfused myocardial infarction (MI) using semi-automatic segmentation software (SASS) in a rat model. Materials and Methods. 5 healthy rats were used to validate left ventricular mass (LVM) measured by MRI with postmortem values. 5 sham and 7 infarcted rats were scanned at 2 and 4 weeks after surgery to allow for functional and structural analysis of the heart. Measurements included ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and LVM. Changes in different regions of the heart were quantified using wall thickness analyses. Results. LVM validation in healthy rats demonstrated high correlation between MR and postmortem values. Functional assessment at 4 weeks after MI revealed considerable reduction in EF, increases in ESV, EDV, and LVM, and contractile dysfunction in infarcted and noninfarcted regions. Conclusion. Clinical 3T MRI with a small animal coil and GE sequence generated images in a rat heart with adequate signal-to-noise ratio (SNR) for successful semiautomatic segmentation to accurately and rapidly evaluate long-term LVR after MI. DA - 2012 DB - OpenUCT DP - University of Cape Town IS - 4 J1 - Journal of Biomedicine and Biotechnology LK - https://open.uct.ac.za PY - 2012 SM - 1110-7243 SM - 1110-7251 T1 - Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner TI - Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner UR - http://hdl.handle.net/11427/34501 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34501
dc.identifier.vancouvercitationSaleh MG, Sharp S, Alhamud A, Spottiswoode BS, van der Kouwe AJW, Davies NH, et al. Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner. Journal of Biomedicine and Biotechnology. 2012;2012(4):174 - 177. http://hdl.handle.net/11427/34501.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Cardiothoracic Surgery
dc.publisher.facultyFaculty of Health Sciences
dc.sourceJournal of Biomedicine and Biotechnology
dc.source.journalissue4
dc.source.journalvolume2012
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1155/2012/504037
dc.subject.otherAnimals
dc.subject.otherDisease Models, Animal
dc.subject.otherHeart Ventricles
dc.subject.otherMagnetic Resonance Imaging
dc.subject.otherMale
dc.subject.otherMyocardial Infarction
dc.subject.otherMyocardial Reperfusion Injury
dc.subject.otherOrgan Size
dc.subject.otherRats
dc.subject.otherRats, Wistar
dc.subject.otherTime Factors
dc.subject.otherVentricular Remodeling
dc.titleLong-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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