Laboratory investigation of low positive and discrepant HIV serology results

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dc.contributor.advisorKorsman, Stephenen_ZA
dc.contributor.advisorHsiao, Marvinen_ZA
dc.contributor.authorHans, Luciaen_ZA
dc.date.accessioned2014-08-15T14:03:31Z
dc.date.available2014-08-15T14:03:31Z
dc.date.issued2014en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractIn our diagnostic virology laboratory, we test on average 1500 samples for HIV antibody/antigen each month, of which 0.6% produces problematic results. These problematic samples produce either weakly reactive screening and confirmatory results or, discrepant screening and confirmatory results. Both scenarios require additional tests to confirm HIV status thus increasing cost and turnaround time. There is a need to devise an optimal strategy within the laboratory to rapidly and easily manage these samples with minimal additional cost. The WHO recommends three HIV testing strategies. Strategy I ensures blood transfusion safety while strategies II and III are used for both surveillance and diagnostics in high prevalence and low prevalence areas respectively.1The 2010 National antenatal sentinel HIV & syphilis prevalence study reported the South African HIV prevalence as 30.2%.2 There were 1.8 million new cases of HIV infection in Sub-Saharan Africa in 2011.3South Africa (SA) is a high prevalence country and therefore the national HIV testing guideline is based on strategy II. The HIV screening and confirmatory strategy at Groote Schuur is based on these recommendations.en_ZA
dc.identifier.apacitationHans, L. (2014). <i>Laboratory investigation of low positive and discrepant HIV serology results</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Virology. Retrieved from http://hdl.handle.net/11427/6557en_ZA
dc.identifier.chicagocitationHans, Lucia. <i>"Laboratory investigation of low positive and discrepant HIV serology results."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2014. http://hdl.handle.net/11427/6557en_ZA
dc.identifier.citationHans, L. 2014. Laboratory investigation of low positive and discrepant HIV serology results. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Hans, Lucia AB - In our diagnostic virology laboratory, we test on average 1500 samples for HIV antibody/antigen each month, of which 0.6% produces problematic results. These problematic samples produce either weakly reactive screening and confirmatory results or, discrepant screening and confirmatory results. Both scenarios require additional tests to confirm HIV status thus increasing cost and turnaround time. There is a need to devise an optimal strategy within the laboratory to rapidly and easily manage these samples with minimal additional cost. The WHO recommends three HIV testing strategies. Strategy I ensures blood transfusion safety while strategies II and III are used for both surveillance and diagnostics in high prevalence and low prevalence areas respectively.1The 2010 National antenatal sentinel HIV & syphilis prevalence study reported the South African HIV prevalence as 30.2%.2 There were 1.8 million new cases of HIV infection in Sub-Saharan Africa in 2011.3South Africa (SA) is a high prevalence country and therefore the national HIV testing guideline is based on strategy II. The HIV screening and confirmatory strategy at Groote Schuur is based on these recommendations. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Laboratory investigation of low positive and discrepant HIV serology results TI - Laboratory investigation of low positive and discrepant HIV serology results UR - http://hdl.handle.net/11427/6557 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6557
dc.identifier.vancouvercitationHans L. Laboratory investigation of low positive and discrepant HIV serology results. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6557en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleLaboratory investigation of low positive and discrepant HIV serology resultsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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