Surgical restoration of maxillofacial defects by transport disc distraction osteogenesis : engineering aspects

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dc.contributor.advisorVicatos, Georgeen_ZA
dc.contributor.authorBoonzaaier, James Angusen_ZA
dc.date.accessioned2014-07-31T11:29:48Z
dc.date.available2014-07-31T11:29:48Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractTransport disc distraction osteogenesis (TDDO) harnesses the natural healing mechanisms of bone to regenerate, and thus repairs, bone defects. Presently, no system is available for applying TDDO to the maxillary anatomy; specifically anterior-to-posterior distraction on a three-dimensional curvilinear vector. The objective of this study was to devise a system to enable repair of the defective maxilla. The mechanical and ergonomic requirements of treatment by TDDO were investigated in the literature and through consultation with experts in the medical and bio-medical engineering fields. These requirements were distilled into a definitive Product Requirement Specification. Three iterative versions of the device were manufactured and tested. After satisfying the functional requirements in bench-tests, each version of the device was evaluated clinically. The operational performance of each device directed refinement of subsequent versions, directing major improvements to ease-of-use and comfort. The project culminated in a fully-functional maxillary TDDO device that addresses the requirements of both surgeon and patient. Proven in practice, the prototype can be easily and accurately customised by the surgeon to suit a wide range of defective maxillofacial geometries. The current version of the device performed successfully in bench-testing, confirming the strength of critical features and demonstrating the presence of adequate safety factors. The current version of the device has been implemented in two clinical cases where it successfully facilitated the repair of substantialdefects of the maxillary alveolus and hard palate. In total, four patients with large maxillary defects were treated with successful outcomes using devices developed in this project. One case has reached completion, with structural restoration of the maxillary alveolus and hard palate, and supporting permanent implanted dentition. Three ongoing cases are awaiting consolidation of the bone regenerate before final dental rehabilitation can commence.en_ZA
dc.identifier.apacitationBoonzaaier, J. A. (2013). <i>Surgical restoration of maxillofacial defects by transport disc distraction osteogenesis : engineering aspects</i>. (Thesis). University of Cape Town ,Faculty of Engineering & the Built Environment ,Department of Mechanical Engineering. Retrieved from http://hdl.handle.net/11427/5561en_ZA
dc.identifier.chicagocitationBoonzaaier, James Angus. <i>"Surgical restoration of maxillofacial defects by transport disc distraction osteogenesis : engineering aspects."</i> Thesis., University of Cape Town ,Faculty of Engineering & the Built Environment ,Department of Mechanical Engineering, 2013. http://hdl.handle.net/11427/5561en_ZA
dc.identifier.citationBoonzaaier, J. 2013. Surgical restoration of maxillofacial defects by transport disc distraction osteogenesis : engineering aspects. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Boonzaaier, James Angus AB - Transport disc distraction osteogenesis (TDDO) harnesses the natural healing mechanisms of bone to regenerate, and thus repairs, bone defects. Presently, no system is available for applying TDDO to the maxillary anatomy; specifically anterior-to-posterior distraction on a three-dimensional curvilinear vector. The objective of this study was to devise a system to enable repair of the defective maxilla. The mechanical and ergonomic requirements of treatment by TDDO were investigated in the literature and through consultation with experts in the medical and bio-medical engineering fields. These requirements were distilled into a definitive Product Requirement Specification. Three iterative versions of the device were manufactured and tested. After satisfying the functional requirements in bench-tests, each version of the device was evaluated clinically. The operational performance of each device directed refinement of subsequent versions, directing major improvements to ease-of-use and comfort. The project culminated in a fully-functional maxillary TDDO device that addresses the requirements of both surgeon and patient. Proven in practice, the prototype can be easily and accurately customised by the surgeon to suit a wide range of defective maxillofacial geometries. The current version of the device performed successfully in bench-testing, confirming the strength of critical features and demonstrating the presence of adequate safety factors. The current version of the device has been implemented in two clinical cases where it successfully facilitated the repair of substantialdefects of the maxillary alveolus and hard palate. In total, four patients with large maxillary defects were treated with successful outcomes using devices developed in this project. One case has reached completion, with structural restoration of the maxillary alveolus and hard palate, and supporting permanent implanted dentition. Three ongoing cases are awaiting consolidation of the bone regenerate before final dental rehabilitation can commence. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Surgical restoration of maxillofacial defects by transport disc distraction osteogenesis : engineering aspects TI - Surgical restoration of maxillofacial defects by transport disc distraction osteogenesis : engineering aspects UR - http://hdl.handle.net/11427/5561 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/5561
dc.identifier.vancouvercitationBoonzaaier JA. Surgical restoration of maxillofacial defects by transport disc distraction osteogenesis : engineering aspects. [Thesis]. University of Cape Town ,Faculty of Engineering & the Built Environment ,Department of Mechanical Engineering, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/5561en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Mechanical Engineeringen_ZA
dc.publisher.facultyFaculty of Engineering and the Built Environment
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMechanical Engineeringen_ZA
dc.titleSurgical restoration of maxillofacial defects by transport disc distraction osteogenesis : engineering aspectsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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