Cardiac Magnetic Resonance to Detect the Underlying Substrate in Patients with Frequent Idiopathic Ventricular Arrhythmias

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dc.contributor.authorNikolaidou, Chrysovalantou
dc.contributor.authorKotanidis, Christos P
dc.contributor.authorWijesurendra, Rohan
dc.contributor.authorLeal-Pelado, Joana
dc.contributor.authorKouskouras, Konstantinos
dc.contributor.authorVassilikos, Vassilios P
dc.contributor.authorKarvounis, Haralambos
dc.contributor.authorNtusi, Ntobeko
dc.contributor.authorAntoniades, Charalambos
dc.contributor.authorNeubauer, Stefan
dc.contributor.authorKaramitsos, Theodoros D.
dc.date.accessioned2021-10-12T13:53:39Z
dc.date.available2021-10-12T13:53:39Z
dc.date.issued2021-06-18
dc.date.updated2021-07-08T14:23:10Z
dc.description.abstractBackground: A routine diagnostic work-up does not identify structural abnormalities in a substantial proportion of patients with idiopathic ventricular arrhythmias (VAs). We investigated the added value of cardiac magnetic resonance (CMR) imaging in this group of patients. Methods: A single-centre prospective study was undertaken of 72 patients (mean age 46 ± 16 years; 53% females) with frequent premature ventricular contractions (PVCs ≥ 500/24 h) and/or non-sustained ventricular tachycardia (NSVT), an otherwise normal electrocardiogram, normal echocardiography and no coronary artery disease. Results: CMR provided an additional diagnostic yield in 54.2% of patients. The most prevalent diagnosis was previous myocarditis (23.6%) followed by possible PVC-related cardiomyopathy (20.8%), non-ischaemic cardiomyopathy (8.3%) and ischaemic heart disease (1.4%). The predictors of abnormal CMR findings were male gender, age and PVCs/NSVT non-outflow tract-related or with multiple morphologies. Patients with VAs had an impaired peak left ventricular (LV) global radial strain (GRS) compared with the controls (28.88% (IQR: 25.87% to 33.97%) vs. 36.65% (IQR: 33.19% to 40.2%), <i>p</i> &lt; 0.001) and a global circumferential strain (GCS) (−17.66% (IQR: −19.62% to −16.23%) vs. −20.66% (IQR: −21.72% to −19.6%), <i>p</i> &lt; 0.001). Conclusion: CMR reveals abnormalities in a significant proportion of patients with frequent idiopathic VAs. Male gender, age and non-outflow tract PVC origin can be clinical indicators for CMR referral.en_US
dc.identifierdoi: 10.3390/diagnostics11061109
dc.identifier.apacitationNikolaidou, C., Kotanidis, C. P., Wijesurendra, R., Leal-Pelado, J., Kouskouras, K., Vassilikos, V. P., ... Karamitsos, Theodoros D. (2021). Cardiac Magnetic Resonance to Detect the Underlying Substrate in Patients with Frequent Idiopathic Ventricular Arrhythmias. <i>Diagnostics</i>, 11(6), 1109. http://hdl.handle.net/11427/35209en_ZA
dc.identifier.chicagocitationNikolaidou, Chrysovalantou, Christos P Kotanidis, Rohan Wijesurendra, Joana Leal-Pelado, Konstantinos Kouskouras, Vassilios P Vassilikos, Haralambos Karvounis, et al "Cardiac Magnetic Resonance to Detect the Underlying Substrate in Patients with Frequent Idiopathic Ventricular Arrhythmias." <i>Diagnostics</i> 11, 6. (2021): 1109. http://hdl.handle.net/11427/35209en_ZA
dc.identifier.citationNikolaidou, C., Kotanidis, C.P., Wijesurendra, R., Leal-Pelado, J., Kouskouras, K., Vassilikos, V.P., Karvounis, H. & Ntusi, N. et al. 2021. Cardiac Magnetic Resonance to Detect the Underlying Substrate in Patients with Frequent Idiopathic Ventricular Arrhythmias. <i>Diagnostics.</i> 11(6):1109. http://hdl.handle.net/11427/35209en_ZA
dc.identifier.ris TY - Journal Article AU - Nikolaidou, Chrysovalantou AU - Kotanidis, Christos P AU - Wijesurendra, Rohan AU - Leal-Pelado, Joana AU - Kouskouras, Konstantinos AU - Vassilikos, Vassilios P AU - Karvounis, Haralambos AU - Ntusi, Ntobeko AU - Antoniades, Charalambos AU - Neubauer, Stefan AU - Karamitsos, Theodoros D. AB - Background: A routine diagnostic work-up does not identify structural abnormalities in a substantial proportion of patients with idiopathic ventricular arrhythmias (VAs). We investigated the added value of cardiac magnetic resonance (CMR) imaging in this group of patients. Methods: A single-centre prospective study was undertaken of 72 patients (mean age 46 ± 16 years; 53% females) with frequent premature ventricular contractions (PVCs ≥ 500/24 h) and/or non-sustained ventricular tachycardia (NSVT), an otherwise normal electrocardiogram, normal echocardiography and no coronary artery disease. Results: CMR provided an additional diagnostic yield in 54.2% of patients. The most prevalent diagnosis was previous myocarditis (23.6%) followed by possible PVC-related cardiomyopathy (20.8%), non-ischaemic cardiomyopathy (8.3%) and ischaemic heart disease (1.4%). The predictors of abnormal CMR findings were male gender, age and PVCs/NSVT non-outflow tract-related or with multiple morphologies. Patients with VAs had an impaired peak left ventricular (LV) global radial strain (GRS) compared with the controls (28.88% (IQR: 25.87% to 33.97%) vs. 36.65% (IQR: 33.19% to 40.2%), <i>p</i> &lt; 0.001) and a global circumferential strain (GCS) (−17.66% (IQR: −19.62% to −16.23%) vs. −20.66% (IQR: −21.72% to −19.6%), <i>p</i> &lt; 0.001). Conclusion: CMR reveals abnormalities in a significant proportion of patients with frequent idiopathic VAs. Male gender, age and non-outflow tract PVC origin can be clinical indicators for CMR referral. DA - 2021-06-18 DB - OpenUCT DP - University of Cape Town IS - 6 J1 - Diagnostics LK - https://open.uct.ac.za PY - 2021 T1 - Cardiac Magnetic Resonance to Detect the Underlying Substrate in Patients with Frequent Idiopathic Ventricular Arrhythmias TI - Cardiac Magnetic Resonance to Detect the Underlying Substrate in Patients with Frequent Idiopathic Ventricular Arrhythmias UR - http://hdl.handle.net/11427/35209 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/35209
dc.identifier.vancouvercitationNikolaidou C, Kotanidis CP, Wijesurendra R, Leal-Pelado J, Kouskouras K, Vassilikos VP, et al. Cardiac Magnetic Resonance to Detect the Underlying Substrate in Patients with Frequent Idiopathic Ventricular Arrhythmias. Diagnostics. 2021;11(6):1109. http://hdl.handle.net/11427/35209.en_ZA
dc.language.isoenen_US
dc.publisher.departmentDepartment of Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceDiagnosticsen_US
dc.source.journalissue6en_US
dc.source.journalvolume11en_US
dc.source.pagination1109en_US
dc.source.urihttps://www.mdpi.com/journal/diagnostics
dc.titleCardiac Magnetic Resonance to Detect the Underlying Substrate in Patients with Frequent Idiopathic Ventricular Arrhythmiasen_US
dc.typeJournal Articleen_US
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