Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum

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dc.contributor.authorHamann, A R
dc.contributor.authorde Kock, C
dc.contributor.authorSmith, P J
dc.contributor.authorvan Otterlo, W A
dc.contributor.authorBlackie, M A
dc.date.accessioned2016-05-17T12:23:24Z
dc.date.available2016-05-17T12:23:24Z
dc.date.issued2013
dc.date.updated2016-05-17T12:06:48Z
dc.description.abstractUsing 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitrobiological activity of four of the compounds on the Plasmodium falciparumchloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 /iM as the lowest inhibitory concentration.en_ZA
dc.identifier.apacitationHamann, A. R., de Kock, C., Smith, P. J., van Otterlo, W. A., & Blackie, M. A. (2013). Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum. <i>South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie</i>, http://hdl.handle.net/11427/19702en_ZA
dc.identifier.chicagocitationHamann, A R, C de Kock, P J Smith, W A van Otterlo, and M A Blackie "Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum." <i>South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie</i> (2013) http://hdl.handle.net/11427/19702en_ZA
dc.identifier.citationHamann, A. R., De Kock, C., Smith, P. J., Van Otterlo, W. A., & Blackie, M. A. (2013). Synthesis of Triazole-linked 2-Trichloromethylquinazolines and Exploration of Their Efficacy Against P falciparum. South African Journal of Chemistry, 66, 231-236.en_ZA
dc.identifier.issn0379-4350en_ZA
dc.identifier.ris TY - Journal Article AU - Hamann, A R AU - de Kock, C AU - Smith, P J AU - van Otterlo, W A AU - Blackie, M A AB - Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitrobiological activity of four of the compounds on the Plasmodium falciparumchloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 /iM as the lowest inhibitory concentration. DA - 2013 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 SM - 0379-4350 T1 - Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum TI - Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum UR - http://hdl.handle.net/11427/19702 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/19702
dc.identifier.vancouvercitationHamann AR, de Kock C, Smith PJ, van Otterlo WA, Blackie MA. Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum. South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie. 2013; http://hdl.handle.net/11427/19702.en_ZA
dc.languageengen_ZA
dc.publisherSouth African Chemical Instituteen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceSouth African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemieen_ZA
dc.source.urihttp://www.journals.co.za/sajchem/
dc.subject.othermalaria
dc.subject.other2-trichloromethylquinazoline
dc.subject.othercopper click chemistry
dc.subject.other1,2,3-triazole
dc.titleSynthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparumen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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