Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review

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dc.contributor.authorHussey, Hannah
dc.contributor.authorAbdullahi, Leila
dc.contributor.authorCollins, Jamie
dc.contributor.authorMuloiwa, Rudzani
dc.contributor.authorHussey, Gregory
dc.contributor.authorKagina, Benjamin
dc.date.accessioned2021-10-08T06:20:32Z
dc.date.available2021-10-08T06:20:32Z
dc.date.issued2017
dc.description.abstractBACKGROUND: Varicella zoster virus (VZV) causes varicella and herpes zoster. These vaccine preventable diseases are common globally. Most available data on VZV epidemiology are from industrialised temperate countries and cannot be used to guide decisions on the immunization policy against VZV in Africa. This systematic review aims to review the published data on VZV morbidity and mortality in Africa. METHODS: All published studies conducted in Africa from 1974 to 2015 were eligible. Eligible studies must have reported any VZV epidemiological measure (incidence, prevalence, hospitalization rate and mortality rate). For inclusion in the review, studies must have used a defined VZV case definition, be it clinical or laboratory-based. RESULTS: Twenty articles from 13 African countries were included in the review. Most included studies were cross-sectional, conducted on hospitalized patients, and half of the studies used varying serological methods for diagnosis. VZV seroprevalence was very high among adults. Limited data on VZV seroprevalence in children showed very low seropositivity to anti-VZV antibodies. Co-morbidity with VZV was common. CONCLUSION: There is lack of quality data that could be used to develop VZV control programmes, including vaccination, in Africa. TRIAL REGISTRATION: PROSPERO 2015: CRD42015026144 .
dc.identifier.apacitationHussey, H., Abdullahi, L., Collins, J., Muloiwa, R., Hussey, G., & Kagina, B. (2017). Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review. <i>BMC Infectious Diseases</i>, 17(1), 174 - 177. http://hdl.handle.net/11427/34298en_ZA
dc.identifier.chicagocitationHussey, Hannah, Leila Abdullahi, Jamie Collins, Rudzani Muloiwa, Gregory Hussey, and Benjamin Kagina "Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review." <i>BMC Infectious Diseases</i> 17, 1. (2017): 174 - 177. http://hdl.handle.net/11427/34298en_ZA
dc.identifier.citationHussey, H., Abdullahi, L., Collins, J., Muloiwa, R., Hussey, G. & Kagina, B. 2017. Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review. <i>BMC Infectious Diseases.</i> 17(1):174 - 177. http://hdl.handle.net/11427/34298en_ZA
dc.identifier.issn1471-2334
dc.identifier.ris TY - Journal Article AU - Hussey, Hannah AU - Abdullahi, Leila AU - Collins, Jamie AU - Muloiwa, Rudzani AU - Hussey, Gregory AU - Kagina, Benjamin AB - BACKGROUND: Varicella zoster virus (VZV) causes varicella and herpes zoster. These vaccine preventable diseases are common globally. Most available data on VZV epidemiology are from industrialised temperate countries and cannot be used to guide decisions on the immunization policy against VZV in Africa. This systematic review aims to review the published data on VZV morbidity and mortality in Africa. METHODS: All published studies conducted in Africa from 1974 to 2015 were eligible. Eligible studies must have reported any VZV epidemiological measure (incidence, prevalence, hospitalization rate and mortality rate). For inclusion in the review, studies must have used a defined VZV case definition, be it clinical or laboratory-based. RESULTS: Twenty articles from 13 African countries were included in the review. Most included studies were cross-sectional, conducted on hospitalized patients, and half of the studies used varying serological methods for diagnosis. VZV seroprevalence was very high among adults. Limited data on VZV seroprevalence in children showed very low seropositivity to anti-VZV antibodies. Co-morbidity with VZV was common. CONCLUSION: There is lack of quality data that could be used to develop VZV control programmes, including vaccination, in Africa. TRIAL REGISTRATION: PROSPERO 2015: CRD42015026144 . DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Infectious Diseases LK - https://open.uct.ac.za PY - 2017 SM - 1471-2334 T1 - Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review TI - Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review UR - http://hdl.handle.net/11427/34298 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34298
dc.identifier.vancouvercitationHussey H, Abdullahi L, Collins J, Muloiwa R, Hussey G, Kagina B. Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review. BMC Infectious Diseases. 2017;17(1):174 - 177. http://hdl.handle.net/11427/34298.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Medical Microbiology
dc.publisher.facultyFaculty of Health Sciences
dc.sourceBMC Infectious Diseases
dc.source.journalissue1
dc.source.journalvolume17
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s12879-017-2815-9
dc.subject.otherVaricella
dc.subject.otherZoster
dc.subject.otherShingles
dc.subject.otherChickenpox
dc.subject.otherAfrica
dc.subject.otherEpidemiology
dc.subject.otherJournal Article
dc.titleVaricella zoster virus-associated morbidity and mortality in Africa – a systematic review
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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