Health-related quality of life among Kenyan adolescents in the context of HIV: measurement issues and risk factors

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dc.contributor.advisorSchneider, Marguerite
dc.contributor.advisorCarney, Tara
dc.contributor.advisorAbubakar, Amina
dc.contributor.authorDenge, Adam Mabrouk Adan
dc.date.accessioned2026-08-06T07:13:59Z
dc.date.available2026-08-06T07:13:59Z
dc.date.issued2023
dc.date.updated2026-08-06T07:08:46Z
dc.description.abstract. Background: Lack of validated health-related quality of Life (HRQoL) measures is one of the significant challenges in describing HRQoL among adolescents in sub-Saharan Africa andparticularly Kenya. The aims of this study were (i) to assess the reliability and validity of the Swahili version KIDSCREEN-52 (a measure of HRQoL) when administered to adolescents in Coastal Kenya and (ii) to investigate risk factors associated with poor HRQoL as measured by KIDSCREEN-52 among these adolescents. Method: KIDSCREEN-52 was translated from its original language (English) to Swahilifollowing the translation guidelines developed by the original KIDSCREEN group. Data analysis was performed from 558 adolescents (158 adolescents living with HIV, 200 HIV exposed uninfected and 200 community controls) aged 11-17 to examine the reliability, construct validity and divergent validity of the Swahili version of KIDSCREEN-52. Multivariable linear regression was conducted to determine the correlates of HRQoL among adolescents. Results: The Swahili version of KIDSCREEN-52 demonstrated good internal consistency with Cronbach alpha ranges of 0.74-0.91 and McDonald's omega ranges of 0.71-0.93 across the three study groups. The measure had a good construct validity, and the one-factor structure of the tool was obtained from the confirmatory factor analysis (CFA) ([overall Comparative Fit Index = 1.00, Tucker Lewis Index = 1.04, Root Mean Square of Error Approximation = 0.000 and p-value of 1.00]. The Swahili version of KIDCSREEN-52 significantly correlated with PHQ-9 scores (r = -0.107, p= 0.011) indicating divergent validity. Among all adolescents (i.e. from the three groups),HIV status, male sex and depressive symptoms were independent predictors of poor HRQoL. Conclusion: The findings demonstrate that the Swahili version of KIDSCREEN-52 is a reliable and valid HRQoL assessment tool. Additionally, the results indicate that we need to prioritize interventions to enhance the quality of life of prenatally infected adolescents alongside those who present with depressive symptoms.
dc.identifier.apacitationDenge, A. M. A. (2023). <i>Health-related quality of life among Kenyan adolescents in the context of HIV: measurement issues and risk factors</i>. (). University of Cape Town ,Faculty of Health Sciences ,Centre for Public Mental Health. Retrieved from http://hdl.handle.net/11427/43705en_ZA
dc.identifier.chicagocitationDenge, Adam Mabrouk Adan. <i>"Health-related quality of life among Kenyan adolescents in the context of HIV: measurement issues and risk factors."</i> ., University of Cape Town ,Faculty of Health Sciences ,Centre for Public Mental Health, 2023. http://hdl.handle.net/11427/43705en_ZA
dc.identifier.citationDenge, A.M.A. 2023. Health-related quality of life among Kenyan adolescents in the context of HIV: measurement issues and risk factors. . University of Cape Town ,Faculty of Health Sciences ,Centre for Public Mental Health. http://hdl.handle.net/11427/43705en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Denge, Adam Mabrouk Adan AB - . Background: Lack of validated health-related quality of Life (HRQoL) measures is one of the significant challenges in describing HRQoL among adolescents in sub-Saharan Africa andparticularly Kenya. The aims of this study were (i) to assess the reliability and validity of the Swahili version KIDSCREEN-52 (a measure of HRQoL) when administered to adolescents in Coastal Kenya and (ii) to investigate risk factors associated with poor HRQoL as measured by KIDSCREEN-52 among these adolescents. Method: KIDSCREEN-52 was translated from its original language (English) to Swahilifollowing the translation guidelines developed by the original KIDSCREEN group. Data analysis was performed from 558 adolescents (158 adolescents living with HIV, 200 HIV exposed uninfected and 200 community controls) aged 11-17 to examine the reliability, construct validity and divergent validity of the Swahili version of KIDSCREEN-52. Multivariable linear regression was conducted to determine the correlates of HRQoL among adolescents. Results: The Swahili version of KIDSCREEN-52 demonstrated good internal consistency with Cronbach alpha ranges of 0.74-0.91 and McDonald's omega ranges of 0.71-0.93 across the three study groups. The measure had a good construct validity, and the one-factor structure of the tool was obtained from the confirmatory factor analysis (CFA) ([overall Comparative Fit Index = 1.00, Tucker Lewis Index = 1.04, Root Mean Square of Error Approximation = 0.000 and p-value of 1.00]. The Swahili version of KIDCSREEN-52 significantly correlated with PHQ-9 scores (r = -0.107, p= 0.011) indicating divergent validity. Among all adolescents (i.e. from the three groups),HIV status, male sex and depressive symptoms were independent predictors of poor HRQoL. Conclusion: The findings demonstrate that the Swahili version of KIDSCREEN-52 is a reliable and valid HRQoL assessment tool. Additionally, the results indicate that we need to prioritize interventions to enhance the quality of life of prenatally infected adolescents alongside those who present with depressive symptoms. DA - 2023 DB - OpenUCT DP - University of Cape Town KW - HIV, AIDS KW - Kenya KW - risk factors LK - https://open.uct.ac.za PB - University of Cape Town PY - 2023 T1 - Health-related quality of life among Kenyan adolescents in the context of HIV: measurement issues and risk factors TI - Health-related quality of life among Kenyan adolescents in the context of HIV: measurement issues and risk factors UR - http://hdl.handle.net/11427/43705 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/43705
dc.identifier.vancouvercitationDenge AMA. Health-related quality of life among Kenyan adolescents in the context of HIV: measurement issues and risk factors. []. University of Cape Town ,Faculty of Health Sciences ,Centre for Public Mental Health, 2023 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/43705en_ZA
dc.language.rfc3066eng
dc.publisher.departmentCentre for Public Mental Health
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.subjectHIV, AIDS
dc.subjectKenya
dc.subjectrisk factors
dc.titleHealth-related quality of life among Kenyan adolescents in the context of HIV: measurement issues and risk factors
dc.typeThesis / Dissertation
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMPhil
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