Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study

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dc.contributor.advisorTemmingh, Henken_ZA
dc.contributor.authorShelly, James Bradlyen_ZA
dc.date.accessioned2016-02-03T14:29:47Z
dc.date.available2016-02-03T14:29:47Z
dc.date.issued2015en_ZA
dc.descriptionIncludes bibliographical referencesen_ZA
dc.description.abstractObjective: To determine the occurrence and associations of Schneiderian first-rank symptoms in patients diagnosed with schizophrenia and methamphetamine psychosis using structured clinical interviews for DSM-IV (SCID-I). Method: Data from SCID-I interviews collected on two samples of patients, diagnosed with schizophrenia and with methamphetamine psychosis, as part of two separate research projects, was retrieved from the respective databases and compared. The two groups were compared on the presence of any one first rank symptom, those who had two first-rank symptoms, and those who had more than two first-rank symptoms. We calculated the prevalence of different first-rank symptoms in schizophrenia and methamphetamine psychosis. We further performed a logistic regression and calculated adjusted and unadjusted odds ratios for the association between first-rank symptoms and diagnosis. Results: One hundred and two patients fulfilled inclusion criteria for the study, 33 from the methamphetamine psychosis sample, and 69 from the schizophrenia sample. Prevalence of one, two, and more than two first-rank symptoms in the methamphetamine psychosis and schizophrenia groups was calculated as 69.6% and 69.7%, 21.2% and 20.3 %, and 27.3% and 27.5% respectively. After adjusting for covariates, thought broadcasting occurred significantly more often in patients with schizophrenia compared to those with methamphetamine psychosis (Odds ratio=3.61; 95% CI: 1.26-10.33; p<0.05). In turn, the odds of having auditory hallucinations in the form of voices conversing was significantly lower in patients with schizophrenia compared to those with methamphetamine psychosis (Odds ratio=0.27; 95% CI: 0.1-0.75; p<0.05). We found no significant association between any other first-rank symptoms as measured by the SCID-I and a diagnosis of schizophrenia or methamphetamine psychosis. Conclusion: The symptom of thought broadcasting was significantly more likely to occur in patients diagnosed with schizophrenia than in patients diagnosed with methamphetamine psychosis. Auditory hallucinations of voices heard conversing was significantly less likely to occur in patients with schizophrenia than in those with methamphetamine psychosis. Overall, there was a significant overlap of first-rank symptoms and a diagnosis of either schizophrenia or methamphetamine psychosis, but this study did not show that patients with a diagnosis of schizophrenia are more likely to have first-rank symptoms when compared to those with methamphetamine psychosis.en_ZA
dc.identifier.apacitationShelly, J. B. (2015). <i>Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health. Retrieved from http://hdl.handle.net/11427/16725en_ZA
dc.identifier.chicagocitationShelly, James Bradly. <i>"Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health, 2015. http://hdl.handle.net/11427/16725en_ZA
dc.identifier.citationShelly, J. 2015. Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Shelly, James Bradly AB - Objective: To determine the occurrence and associations of Schneiderian first-rank symptoms in patients diagnosed with schizophrenia and methamphetamine psychosis using structured clinical interviews for DSM-IV (SCID-I). Method: Data from SCID-I interviews collected on two samples of patients, diagnosed with schizophrenia and with methamphetamine psychosis, as part of two separate research projects, was retrieved from the respective databases and compared. The two groups were compared on the presence of any one first rank symptom, those who had two first-rank symptoms, and those who had more than two first-rank symptoms. We calculated the prevalence of different first-rank symptoms in schizophrenia and methamphetamine psychosis. We further performed a logistic regression and calculated adjusted and unadjusted odds ratios for the association between first-rank symptoms and diagnosis. Results: One hundred and two patients fulfilled inclusion criteria for the study, 33 from the methamphetamine psychosis sample, and 69 from the schizophrenia sample. Prevalence of one, two, and more than two first-rank symptoms in the methamphetamine psychosis and schizophrenia groups was calculated as 69.6% and 69.7%, 21.2% and 20.3 %, and 27.3% and 27.5% respectively. After adjusting for covariates, thought broadcasting occurred significantly more often in patients with schizophrenia compared to those with methamphetamine psychosis (Odds ratio=3.61; 95% CI: 1.26-10.33; p<0.05). In turn, the odds of having auditory hallucinations in the form of voices conversing was significantly lower in patients with schizophrenia compared to those with methamphetamine psychosis (Odds ratio=0.27; 95% CI: 0.1-0.75; p<0.05). We found no significant association between any other first-rank symptoms as measured by the SCID-I and a diagnosis of schizophrenia or methamphetamine psychosis. Conclusion: The symptom of thought broadcasting was significantly more likely to occur in patients diagnosed with schizophrenia than in patients diagnosed with methamphetamine psychosis. Auditory hallucinations of voices heard conversing was significantly less likely to occur in patients with schizophrenia than in those with methamphetamine psychosis. Overall, there was a significant overlap of first-rank symptoms and a diagnosis of either schizophrenia or methamphetamine psychosis, but this study did not show that patients with a diagnosis of schizophrenia are more likely to have first-rank symptoms when compared to those with methamphetamine psychosis. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study TI - Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study UR - http://hdl.handle.net/11427/16725 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16725
dc.identifier.vancouvercitationShelly JB. Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/16725en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Psychiatry and Mental Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPsychiatryen_ZA
dc.titleSchneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative studyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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