Factors predicting walking intolerance in patients with peripheral arterial disease and intermittent claudication
| dc.contributor.author | Parr, B | |
| dc.contributor.author | Noakes, T D | |
| dc.contributor.author | Derman, E W | |
| dc.date.accessioned | 2017-05-11T06:52:54Z | |
| dc.date.available | 2017-05-11T06:52:54Z | |
| dc.date.issued | 2008 | |
| dc.date.updated | 2016-01-08T08:12:12Z | |
| dc.description.abstract | Objective. To determine which physiological variables conduce to walking intolerance in patients with peripheral arterial disease (PAD). Design. The physiological response to a graded treadmill exercise test (GTT) in patients with PAD was characterised. Setting. Patients were recruited from the Department of Vascular Surgery, Groote Schuur Hospital, Cape Town. Subjects. Thirty-one patients diagnosed with PAD were included in the study. Outcome measures. During a GTT, peak oxygen consumption (VO2peak), peak minute ventilation (VEpeak), peak heart rate and peak venous lactate concentrations were measured and compared with those from a comparison group. Anklebrachial index (ABI) was measured at rest and after exercise. During the GTT, maximum walking distance (MWD) and pain-free walking distance (PFWD) were measured to determine walking tolerance. Results. Peak venous lactate concentrations did not correlate significantly with either PFWD (r=–0.08; p=0.3) or MWD (r=–0.03; p=0.4). Resting ABI did not correlate with either MWD (r=0.09; p=0.64) or PFWD (r=–0.19; p=0.29). Subjects terminated exercise at significantly (p<0.05) lower levels of cardiorespiratory effort and venous lactate concentrations than did a sedentary but otherwise healthy comparison group: peak heart rate 156±11 v. 114±22 beats per minute (BPM); p=0.001; and peak venous lactate concentration 9.7±2.7 mmol/l v. 3.28±1.39 mmol/l; p=0.001. Conclusion. Perceived discomfort in these patients is not caused by elevated blood lactate concentrations, a low ABI or limiting cardiorespiratory effort but by other factors not measured in this study. | |
| dc.identifier.apacitation | Parr, B., Noakes, T. D., & Derman, E. W. (2008). Factors predicting walking intolerance in patients with peripheral arterial disease and intermittent claudication. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/24264 | en_ZA |
| dc.identifier.chicagocitation | Parr, B, T D Noakes, and E W Derman "Factors predicting walking intolerance in patients with peripheral arterial disease and intermittent claudication." <i>South African Medical Journal</i> (2008) http://hdl.handle.net/11427/24264 | en_ZA |
| dc.identifier.citation | Parr, B. M., Noakes, T. D., & Derman, W. (2008). Factors predicting walking intolerance in patients with peripheral arterial disease (PAD) and intermittent claudication. South African Medical Journal, 98(12), 958-962. | |
| dc.identifier.ris | TY - Journal Article AU - Parr, B AU - Noakes, T D AU - Derman, E W AB - Objective. To determine which physiological variables conduce to walking intolerance in patients with peripheral arterial disease (PAD). Design. The physiological response to a graded treadmill exercise test (GTT) in patients with PAD was characterised. Setting. Patients were recruited from the Department of Vascular Surgery, Groote Schuur Hospital, Cape Town. Subjects. Thirty-one patients diagnosed with PAD were included in the study. Outcome measures. During a GTT, peak oxygen consumption (VO2peak), peak minute ventilation (VEpeak), peak heart rate and peak venous lactate concentrations were measured and compared with those from a comparison group. Anklebrachial index (ABI) was measured at rest and after exercise. During the GTT, maximum walking distance (MWD) and pain-free walking distance (PFWD) were measured to determine walking tolerance. Results. Peak venous lactate concentrations did not correlate significantly with either PFWD (r=–0.08; p=0.3) or MWD (r=–0.03; p=0.4). Resting ABI did not correlate with either MWD (r=0.09; p=0.64) or PFWD (r=–0.19; p=0.29). Subjects terminated exercise at significantly (p<0.05) lower levels of cardiorespiratory effort and venous lactate concentrations than did a sedentary but otherwise healthy comparison group: peak heart rate 156±11 v. 114±22 beats per minute (BPM); p=0.001; and peak venous lactate concentration 9.7±2.7 mmol/l v. 3.28±1.39 mmol/l; p=0.001. Conclusion. Perceived discomfort in these patients is not caused by elevated blood lactate concentrations, a low ABI or limiting cardiorespiratory effort but by other factors not measured in this study. DA - 2008 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Factors predicting walking intolerance in patients with peripheral arterial disease and intermittent claudication TI - Factors predicting walking intolerance in patients with peripheral arterial disease and intermittent claudication UR - http://hdl.handle.net/11427/24264 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/24264 | |
| dc.identifier.vancouvercitation | Parr B, Noakes TD, Derman EW. Factors predicting walking intolerance in patients with peripheral arterial disease and intermittent claudication. South African Medical Journal. 2008; http://hdl.handle.net/11427/24264. | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | MRC/UCT RU for Exercise and Sport Medicine | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | South African Medical Journal | |
| dc.source.uri | http://www.samj.org.za/index.php/samj | |
| dc.title | Factors predicting walking intolerance in patients with peripheral arterial disease and intermittent claudication | |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |