Leaving the party - withdrawal of South African essential medicines

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dc.contributor.authorWilmshurst, Jo M
dc.contributor.authorBlockman, Marc
dc.contributor.authorArgent, Andrew
dc.contributor.authorGordon-Graham, Eugenie
dc.contributor.authorThomas, Jenny
dc.contributor.authorWhitelaw, Andrew
dc.contributor.authorMcCulloch, Mignon
dc.contributor.authorRamiah, Malitha
dc.contributor.authorDyeshana, H
dc.contributor.authorIreland, Joe
dc.date.accessioned2017-10-25T07:11:11Z
dc.date.available2017-10-25T07:11:11Z
dc.date.issued2005
dc.date.updated2016-01-13T07:31:55Z
dc.description.abstractIn August 2004 pharmacies and drug depots were advised that the sole supplier of parenteral phenobarbitone in South Africa, essential for the management of status epilepticus in children, was stopping production at the end of the same year. Alternative protocols for the management of status epilepticus resulted in more children requiring intensive care intervention (N = 9) at the Red Cross Children’s Hospital, over a 2-month period, than had occurred in any 12-month period since 2000 (2000 N = 3, 2001 N = 1, 2002 N = 1, 2003 N = 2, 2004 N = 7). Other agents that have suffered or are at risk of the same fate are sodium nitroprusside, labetalol and esmolol. Sodium nitroprusside is used extensively in the peri-operative period in cardiac patients requiring after-load reduction. There are no other nitrates with equivalent efficacy. Supply was stopped in 2005 and only reinstated after the pharmaceutical company was contacted directly. Supply of labetalol and esmolol was stopped without warning. Without access to these products it is necessary to resort to agents that are not appropriate for paediatric use. Acetylcysteine (Parvolex), used in the management of acetaminophen overdose, also became unavailable and the supply was re-established only after direct communication with the pharmaceutical company.
dc.identifier.apacitationWilmshurst, J. M., Blockman, M., Argent, A., Gordon-Graham, E., Thomas, J., Whitelaw, A., ... Ireland, J. (2005). Leaving the party - withdrawal of South African essential medicines. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/25753en_ZA
dc.identifier.chicagocitationWilmshurst, Jo M, Marc Blockman, Andrew Argent, Eugenie Gordon-Graham, Jenny Thomas, Andrew Whitelaw, Mignon McCulloch, Malitha Ramiah, H Dyeshana, and Joe Ireland "Leaving the party - withdrawal of South African essential medicines." <i>South African Medical Journal</i> (2005) http://hdl.handle.net/11427/25753en_ZA
dc.identifier.citationWilmshurst, J. M., Blockman, M., Argent, A., Gordon-Graham, E., Thomas, J., Whitelaw, A., ... & Ireland, J. (2006). Leaving the party-withdrawal of South African essential medicines: editorial. South African Medical Journal, 96(5), p-419.
dc.identifier.ris TY - Journal Article AU - Wilmshurst, Jo M AU - Blockman, Marc AU - Argent, Andrew AU - Gordon-Graham, Eugenie AU - Thomas, Jenny AU - Whitelaw, Andrew AU - McCulloch, Mignon AU - Ramiah, Malitha AU - Dyeshana, H AU - Ireland, Joe AB - In August 2004 pharmacies and drug depots were advised that the sole supplier of parenteral phenobarbitone in South Africa, essential for the management of status epilepticus in children, was stopping production at the end of the same year. Alternative protocols for the management of status epilepticus resulted in more children requiring intensive care intervention (N = 9) at the Red Cross Children’s Hospital, over a 2-month period, than had occurred in any 12-month period since 2000 (2000 N = 3, 2001 N = 1, 2002 N = 1, 2003 N = 2, 2004 N = 7). Other agents that have suffered or are at risk of the same fate are sodium nitroprusside, labetalol and esmolol. Sodium nitroprusside is used extensively in the peri-operative period in cardiac patients requiring after-load reduction. There are no other nitrates with equivalent efficacy. Supply was stopped in 2005 and only reinstated after the pharmaceutical company was contacted directly. Supply of labetalol and esmolol was stopped without warning. Without access to these products it is necessary to resort to agents that are not appropriate for paediatric use. Acetylcysteine (Parvolex), used in the management of acetaminophen overdose, also became unavailable and the supply was re-established only after direct communication with the pharmaceutical company. DA - 2005 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Leaving the party - withdrawal of South African essential medicines TI - Leaving the party - withdrawal of South African essential medicines UR - http://hdl.handle.net/11427/25753 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/25753
dc.identifier.vancouvercitationWilmshurst JM, Blockman M, Argent A, Gordon-Graham E, Thomas J, Whitelaw A, et al. Leaving the party - withdrawal of South African essential medicines. South African Medical Journal. 2005; http://hdl.handle.net/11427/25753.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceSouth African Medical Journal
dc.titleLeaving the party - withdrawal of South African essential medicines
dc.typeJournal Article
uct.type.filetype
uct.type.filetypeText
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