The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer

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dc.contributor.advisorParker, M Iqbalen_ZA
dc.contributor.advisorDandara, Colleten_ZA
dc.contributor.authorRoss-Innes, Caryn Sarahen_ZA
dc.date.accessioned2014-07-28T14:55:56Z
dc.date.available2014-07-28T14:55:56Z
dc.date.issued2007en_ZA
dc.descriptionIncludes bibliographical references (leaves 74-83).
dc.description.abstractOesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males. Several risk factors for OSCC have been reported but this study focuses on the role of human papilloma virus (HPV) in the development of OSCC. HPV is a well-known risk factor for cervical cancer resulting in its classification into low- and high-risk HPV types. The role of the different HPV types in OSCC development is not known, but in cervical cancer the critical HPV transforming gene has been shown to be E6. In this project, the effects of HPV11 E6, a low-risk type, and HPV18 E6, a high-risk type, were investigated by transfecting HPV-negative cell lines (EPC2-hTERT, MCF12A and Rat1) with HPV11 and HPV18 E6.en_ZA
dc.identifier.apacitationRoss-Innes, C. S. (2007). <i>The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/3148en_ZA
dc.identifier.chicagocitationRoss-Innes, Caryn Sarah. <i>"The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2007. http://hdl.handle.net/11427/3148en_ZA
dc.identifier.citationRoss-Innes, C. 2007. The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Ross-Innes, Caryn Sarah AB - Oesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males. Several risk factors for OSCC have been reported but this study focuses on the role of human papilloma virus (HPV) in the development of OSCC. HPV is a well-known risk factor for cervical cancer resulting in its classification into low- and high-risk HPV types. The role of the different HPV types in OSCC development is not known, but in cervical cancer the critical HPV transforming gene has been shown to be E6. In this project, the effects of HPV11 E6, a low-risk type, and HPV18 E6, a high-risk type, were investigated by transfecting HPV-negative cell lines (EPC2-hTERT, MCF12A and Rat1) with HPV11 and HPV18 E6. DA - 2007 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer TI - The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer UR - http://hdl.handle.net/11427/3148 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3148
dc.identifier.vancouvercitationRoss-Innes CS. The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2007 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3148en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleThe role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal canceren_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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