An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests

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dc.contributor.authorLange, Leo Stanley
dc.date.accessioned2020-06-08T09:17:51Z
dc.date.available2020-06-08T09:17:51Z
dc.date.issued1967
dc.date.updated2020-04-08T08:24:14Z
dc.description.abstractThe purpose of this project has been to test the postulate that high blood levels of pyruvate encountered in certain conditions such as steroid excess, diabetes mellitus under certain circumstances, and thiamine deficiency, are due to defective removal of pyruvate rather than excessive production. Specific methods of assay and direct studies of pyruvate tolerance were used. Intermediary carbohydrate metabolism was studied in a total of 109 subjects. The history of thiamine deficiency and of the concept of ensymes is outlined and the literature on pyruvate estimation and study in various clinical conditions is reviewed. Direct tests of pyruvate tolerance are discussed and the biochemistry if glucose breakdown is described. the history of analytical methodology for pyruvate is recounted.
dc.identifier.apacitationLange, L. S. (1967). <i>An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests</i>. (). ,Faculty of Health Sciences ,Department of Medicine. Retrieved from en_ZA
dc.identifier.chicagocitationLange, Leo Stanley. <i>"An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests."</i> ., ,Faculty of Health Sciences ,Department of Medicine, 1967. en_ZA
dc.identifier.citationLange, L.S. 1967. An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests. . ,Faculty of Health Sciences ,Department of Medicine. en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Lange, Leo Stanley AB - The purpose of this project has been to test the postulate that high blood levels of pyruvate encountered in certain conditions such as steroid excess, diabetes mellitus under certain circumstances, and thiamine deficiency, are due to defective removal of pyruvate rather than excessive production. Specific methods of assay and direct studies of pyruvate tolerance were used. Intermediary carbohydrate metabolism was studied in a total of 109 subjects. The history of thiamine deficiency and of the concept of ensymes is outlined and the literature on pyruvate estimation and study in various clinical conditions is reviewed. Direct tests of pyruvate tolerance are discussed and the biochemistry if glucose breakdown is described. the history of analytical methodology for pyruvate is recounted. DA - 1967 DB - OpenUCT DP - University of Cape Town KW - metabolism KW - pyruvates LK - https://open.uct.ac.za PY - 1967 T1 - An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests TI - An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests UR - ER - en_ZA
dc.identifier.urihttps://hdl.handle.net/11427/32043
dc.identifier.vancouvercitationLange LS. An investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests. []. ,Faculty of Health Sciences ,Department of Medicine, 1967 [cited yyyy month dd]. Available from: en_ZA
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.subjectmetabolism
dc.subjectpyruvates
dc.titleAn investigation of certain aspects of pyruvate metabolism in man by indirect and direct tolerance tests
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
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