Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa

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dc.contributor.authorKastien-Hilka, Tanja
dc.contributor.authorAbulfathi, Ahmed
dc.contributor.authorRosenkranz, Bernd
dc.contributor.authorBennett, Bryan
dc.contributor.authorSchwenkglenks, Matthias
dc.contributor.authorSinanovic, Edina
dc.date.accessioned2016-05-24T12:34:55Z
dc.date.available2016-05-24T12:34:55Z
dc.date.issued2016-03-11
dc.date.updated2016-05-19T09:18:07Z
dc.description.abstractIntroduction: Tuberculosis (TB) is a leading cause of morbidity and mortality in South Africa. Clinical parameters are important objective outcomes in TB; however they often are not directly correlated with subjective well-being of the patient, but can be assessed using patient-reported outcome (PRO) measures. Health-related quality of life (HRQOL) is a specific PRO generally multi-dimensional in nature and includes physical, mental and social health domains. The inclusion of HRQOL PROs in trials and clinical practice can provide additional information beyondclinical and microbiological parameters. Furthermore, HRQOL may be associated with medication adherence. This review focuses on patient-reported HRQOL and its association with medication adherence in TB patients in South Africa. Methods: A comprehensive search strategy was developed focusing on the impact of TB on patient-reported HRQOL,the existence of a conceptual framework of TB-specific HRQOL, determinants of medication adherence and the association of HRQOL with medication adherence. Data were extracted from all identified articles and additionaldata extraction was performed by two independent reviewers with special focus on longitudinal studies in order to understand changes of HRQOL and adherence over time. Research gaps were identified with regard to patientreported HRQOL and medication adherence. Results: A total of 66 articles met the eligibility criteria. Ten HRQOL studies and one adherence study used a longitudinal design, none of these in South Africa. A variety of different generic and disease-specific HRQOL measures were identified in the articles. In South Africa four HRQOL and five adherence studies (non-longitudinal) were published. Similar factors (socio-demographic, socio-economic, disease-related, therapy-related and psycho-social aspects) affect HRQOL and adherence. Although standard TB treatment improved all health domains, psychological well-being and social functioning remained impaired in microbiologically cured patients after treatment. Conclusion: While evidence of TB impact on HRQOL and medication adherence and their association exists, it is verylimited for the South African situation. No valid and reliable TB-specific HRQOL measures were identified in this systematicreview. An assessment of HRQOL in TB patients in South Africa is required as this may assist with improving current disease management programmes, medication adherence and national treatment guidelines.en_ZA
dc.identifier.apacitationKastien-Hilka, T., Abulfathi, A., Rosenkranz, B., Bennett, B., Schwenkglenks, M., & Sinanovic, E. (2016). Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa. <i>Health and Quality of Life Outcomes</i>, http://hdl.handle.net/11427/19834en_ZA
dc.identifier.chicagocitationKastien-Hilka, Tanja, Ahmed Abulfathi, Bernd Rosenkranz, Bryan Bennett, Matthias Schwenkglenks, and Edina Sinanovic "Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa." <i>Health and Quality of Life Outcomes</i> (2016) http://hdl.handle.net/11427/19834en_ZA
dc.identifier.citationKastien-Hilka, T., Abulfathi, A., Rosenkranz, B., Bennett, B., Schwenkglenks, M., & Sinanovic, E. (2016). Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis–a systematic review of global literature with focus on South Africa. Health and quality of life outcomes, 14(1), 1.en_ZA
dc.identifier.issn1477-7525en_ZA
dc.identifier.ris TY - Journal Article AU - Kastien-Hilka, Tanja AU - Abulfathi, Ahmed AU - Rosenkranz, Bernd AU - Bennett, Bryan AU - Schwenkglenks, Matthias AU - Sinanovic, Edina AB - Introduction: Tuberculosis (TB) is a leading cause of morbidity and mortality in South Africa. Clinical parameters are important objective outcomes in TB; however they often are not directly correlated with subjective well-being of the patient, but can be assessed using patient-reported outcome (PRO) measures. Health-related quality of life (HRQOL) is a specific PRO generally multi-dimensional in nature and includes physical, mental and social health domains. The inclusion of HRQOL PROs in trials and clinical practice can provide additional information beyondclinical and microbiological parameters. Furthermore, HRQOL may be associated with medication adherence. This review focuses on patient-reported HRQOL and its association with medication adherence in TB patients in South Africa. Methods: A comprehensive search strategy was developed focusing on the impact of TB on patient-reported HRQOL,the existence of a conceptual framework of TB-specific HRQOL, determinants of medication adherence and the association of HRQOL with medication adherence. Data were extracted from all identified articles and additionaldata extraction was performed by two independent reviewers with special focus on longitudinal studies in order to understand changes of HRQOL and adherence over time. Research gaps were identified with regard to patientreported HRQOL and medication adherence. Results: A total of 66 articles met the eligibility criteria. Ten HRQOL studies and one adherence study used a longitudinal design, none of these in South Africa. A variety of different generic and disease-specific HRQOL measures were identified in the articles. In South Africa four HRQOL and five adherence studies (non-longitudinal) were published. Similar factors (socio-demographic, socio-economic, disease-related, therapy-related and psycho-social aspects) affect HRQOL and adherence. Although standard TB treatment improved all health domains, psychological well-being and social functioning remained impaired in microbiologically cured patients after treatment. Conclusion: While evidence of TB impact on HRQOL and medication adherence and their association exists, it is verylimited for the South African situation. No valid and reliable TB-specific HRQOL measures were identified in this systematicreview. An assessment of HRQOL in TB patients in South Africa is required as this may assist with improving current disease management programmes, medication adherence and national treatment guidelines. DA - 2016-03-11 DB - OpenUCT DO - 10.1186/s12955-016-0442-6 DP - University of Cape Town J1 - Health and Quality of Life Outcomes LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 SM - 1477-7525 T1 - Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa TI - Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa UR - http://hdl.handle.net/11427/19834 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12955-016-0442-6
dc.identifier.urihttp://hdl.handle.net/11427/19834
dc.identifier.vancouvercitationKastien-Hilka T, Abulfathi A, Rosenkranz B, Bennett B, Schwenkglenks M, Sinanovic E. Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa. Health and Quality of Life Outcomes. 2016; http://hdl.handle.net/11427/19834.en_ZA
dc.languageengen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.publisher.departmentHealth Economics Uniten_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.holderKastien-Hilka et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceHealth and Quality of Life Outcomesen_ZA
dc.source.urihttp://hqlo.biomedcentral.com/
dc.titleHealth-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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