Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs
| dc.contributor.author | Dzobo, Kevin | |
| dc.contributor.author | Naik, Yogeshkumar V | |
| dc.date.accessioned | 2018-11-20T13:43:49Z | |
| dc.date.available | 2018-11-20T13:43:49Z | |
| dc.date.issued | 2013 | |
| dc.date.updated | 2018-11-20T13:41:44Z | |
| dc.description.abstract | Metal toxicity is a threat mainly in the industrialised world where industry discharges many toxic metals into the environment. We investigated the effects of two metals - cadmium and selenium - on the cytosolic antioxidant enzymes and esterases in the liver, kidneys and testes of rats. Male Sprague-Dawley rats( N =28) were divided equally into four groups: control, cadmium, selenium and cadmium/selenium. Salts of the metals were administered intraperitoneally for 15 days. In the liver, cadmium treatment (1.67 mg/kg per day) resulted in a decrease in catalase activity and an increase superoxide dismutase (SOD) activity. Selenium treatment (0.23 mg/kg per day) resulted in increases in glutathione s-transferase, catalase and DT-diaphorase activities. Treatment with both cadmium and selenium resulted in an increase in glutathione peroxidase (GPx) activity. Esterase activities were significantly lower in the presence of cadmium. In the kidney, cadmium treatment caused a decrease in catalase, DT-diaphorase, and SOD activities and selenium supplementation reversed the cadmium-induced decrease in these enzyme activities. Selenium treatment increased catalase and SOD activities in the kidney. In the testis, cadmium treatment decreased GPx and SOD activities, but at the same time increased catalase and DT-diaphorase activities. Esterase activities increased in the presence of selenium in both the kidney and testis. These results suggest that selenium might be toxic to the liver while at the same time play a protective role against cadmium-induced oxidative stress and toxicity in the kidney and testis. | |
| dc.identifier | http://dx.doi.org/10.1590/ sajs.2013/965 | |
| dc.identifier.apacitation | Dzobo, K., & Naik, Y. V. (2013). Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs. <i>South African Journal of Science</i>, http://hdl.handle.net/11427/29072 | en_ZA |
| dc.identifier.chicagocitation | Dzobo, Kevin, and Yogeshkumar V Naik "Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs." <i>South African Journal of Science</i> (2013) http://hdl.handle.net/11427/29072 | en_ZA |
| dc.identifier.citation | Dzobo, K., & Naik, Y. S. (2013). Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs. South African Journal of Science, 109(5-6), 01-08. | |
| dc.identifier.ris | TY - AU - Dzobo, Kevin AU - Naik, Yogeshkumar V AB - Metal toxicity is a threat mainly in the industrialised world where industry discharges many toxic metals into the environment. We investigated the effects of two metals - cadmium and selenium - on the cytosolic antioxidant enzymes and esterases in the liver, kidneys and testes of rats. Male Sprague-Dawley rats( N =28) were divided equally into four groups: control, cadmium, selenium and cadmium/selenium. Salts of the metals were administered intraperitoneally for 15 days. In the liver, cadmium treatment (1.67 mg/kg per day) resulted in a decrease in catalase activity and an increase superoxide dismutase (SOD) activity. Selenium treatment (0.23 mg/kg per day) resulted in increases in glutathione s-transferase, catalase and DT-diaphorase activities. Treatment with both cadmium and selenium resulted in an increase in glutathione peroxidase (GPx) activity. Esterase activities were significantly lower in the presence of cadmium. In the kidney, cadmium treatment caused a decrease in catalase, DT-diaphorase, and SOD activities and selenium supplementation reversed the cadmium-induced decrease in these enzyme activities. Selenium treatment increased catalase and SOD activities in the kidney. In the testis, cadmium treatment decreased GPx and SOD activities, but at the same time increased catalase and DT-diaphorase activities. Esterase activities increased in the presence of selenium in both the kidney and testis. These results suggest that selenium might be toxic to the liver while at the same time play a protective role against cadmium-induced oxidative stress and toxicity in the kidney and testis. DA - 2013 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Science LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs TI - Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs UR - http://hdl.handle.net/11427/29072 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/29072 | |
| dc.identifier.vancouvercitation | Dzobo K, Naik YV. Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs. South African Journal of Science. 2013; http://hdl.handle.net/11427/29072. | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | Department of Clinical Laboratory Sciences | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.publisher.institution | University of Cape Town | |
| dc.source | South African Journal of Science | |
| dc.source.uri | https://www.sajs.co.za/ | |
| dc.subject.other | selenium | |
| dc.subject.other | cadmium | |
| dc.subject.other | antioxidant | |
| dc.subject.other | oxidative stress | |
| dc.subject.other | rat organs | |
| dc.title | Effect of selenium on cadmium-induced oxidative stress and esterase activity in rat organs | |
| dc.type | Journal Article | |
| uct.type.filetype | ||
| uct.type.filetype | Image |