Analysis of desmoplakin in arrythmogenic right ventricular cardiomyopathy

Master Thesis

2010

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http://hdl.handle.net/11427/10466
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thesis_hsf_2010_fish_m.pdf (1.78 MB)
Authors
Fish, Maryam
Supervisors
Mayosi, Bongani
Shaboodien, Gasnat
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University of Cape Town

Department
Department of Medicine
Faculty
Faculty of Health Sciences
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Abstract
It has been shown that all forms of cardiomyopathy, including the dilated, hypertrophic, restrictive, and right ventricular arrhythmogenic forms, are found in African populations. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare muscle disease characterised by fibrofatty replacement of the right ventricular myocardium, leading to electrical instability and eventual heart failure. Dilated cardiomyopathy (DCM) is a disease characterised by a reduction in ventricular wall thickness which leads to reduced contractility and impaired ventricular function. Mutations that cause ARVC have been reported in five desmosomal and three non-desmosomal genes.
Description

Includes bibliographical references (leaves 71-79).

Reference:

Fish, M. 2010. Analysis of desmoplakin in arrythmogenic right ventricular cardiomyopathy. University of Cape Town.

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