Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon

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dc.contributor.authorNoumegni, Steve Raoul Ngongang
dc.contributor.authorNansseu, Jobert Richie
dc.contributor.authorAma, Vicky Jocelyne Moor
dc.contributor.authorBigna, Jean Joël
dc.contributor.authorAssah, Felix Kembe
dc.contributor.authorGuewo-Fokeng, Magellan
dc.contributor.authorLeumi, Steve
dc.contributor.authorKatte, Jean-Claude
dc.contributor.authorDehayem, Mesmin
dc.contributor.authorKengne, André Pascal
dc.contributor.authorSobngwi, Eugène
dc.date.accessioned2021-10-08T07:08:19Z
dc.date.available2021-10-08T07:08:19Z
dc.date.issued2017
dc.description.abstractBACKGROUND: Little is known on the magnitude and correlates of insulin resistance in HIV-infected people in Africa. We determined the prevalence of insulin resistance and investigated associated factors in HIV-infected adult Cameroonians. METHODS: We conducted a cross-sectional study at the Yaoundé Central Hospital, Cameroon; during which we enrolled HIV-infected people aged 30 to 74 years with no previous history of cardiovascular disease. An homeostatic model assessment of insulin resistance (HOMA-IR) like index served to assess insulin sensitivity with insulin resistance defined by values of 2.1 or higher. RESULTS: We included 452 patients (20% men). Their mean age was 44.4 ± 9.8 years and 88.5% of them were on antiretroviral therapy (93.3% on first line regimen including Zidovudine, lamivudine and Efavirenz/Nevirapine). Of all participants, 28.5% were overweight, 19.5% had obesity and 2.0% had diabetes. The prevalence of insulin resistance was 47.3% without any difference between patients on ART and those ART-naïve (48.5% vs. 38.5%; p = 0.480). Obesity was the only factor independently associated with insulin resistance (adjusted odds ratio: 2.28; 95% confidence interval: 1.10-4.72). CONCLUSION: Insulin resistance is present in nearly half of HIV-infected patients in Cameroon despite a low prevalence rate of diabetes, and is associated with obesity.
dc.identifier.apacitationNoumegni, S. R. N., Nansseu, J. R., Ama, V. J. M., Bigna, J. J., Assah, F. K., Guewo-Fokeng, M., ... Sobngwi, E. (2017). Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon. <i>Lipids in Health and Disease</i>, 16(1), 174 - 177. http://hdl.handle.net/11427/34551en_ZA
dc.identifier.chicagocitationNoumegni, Steve Raoul Ngongang, Jobert Richie Nansseu, Vicky Jocelyne Moor Ama, Jean Joël Bigna, Felix Kembe Assah, Magellan Guewo-Fokeng, Steve Leumi, et al "Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon." <i>Lipids in Health and Disease</i> 16, 1. (2017): 174 - 177. http://hdl.handle.net/11427/34551en_ZA
dc.identifier.citationNoumegni, S.R.N., Nansseu, J.R., Ama, V.J.M., Bigna, J.J., Assah, F.K., Guewo-Fokeng, M., Leumi, S. & Katte, J. et al. 2017. Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon. <i>Lipids in Health and Disease.</i> 16(1):174 - 177. http://hdl.handle.net/11427/34551en_ZA
dc.identifier.issn1476-511X
dc.identifier.ris TY - Journal Article AU - Noumegni, Steve Raoul Ngongang AU - Nansseu, Jobert Richie AU - Ama, Vicky Jocelyne Moor AU - Bigna, Jean Joël AU - Assah, Felix Kembe AU - Guewo-Fokeng, Magellan AU - Leumi, Steve AU - Katte, Jean-Claude AU - Dehayem, Mesmin AU - Kengne, André Pascal AU - Sobngwi, Eugène AB - BACKGROUND: Little is known on the magnitude and correlates of insulin resistance in HIV-infected people in Africa. We determined the prevalence of insulin resistance and investigated associated factors in HIV-infected adult Cameroonians. METHODS: We conducted a cross-sectional study at the Yaoundé Central Hospital, Cameroon; during which we enrolled HIV-infected people aged 30 to 74 years with no previous history of cardiovascular disease. An homeostatic model assessment of insulin resistance (HOMA-IR) like index served to assess insulin sensitivity with insulin resistance defined by values of 2.1 or higher. RESULTS: We included 452 patients (20% men). Their mean age was 44.4 ± 9.8 years and 88.5% of them were on antiretroviral therapy (93.3% on first line regimen including Zidovudine, lamivudine and Efavirenz/Nevirapine). Of all participants, 28.5% were overweight, 19.5% had obesity and 2.0% had diabetes. The prevalence of insulin resistance was 47.3% without any difference between patients on ART and those ART-naïve (48.5% vs. 38.5%; p = 0.480). Obesity was the only factor independently associated with insulin resistance (adjusted odds ratio: 2.28; 95% confidence interval: 1.10-4.72). CONCLUSION: Insulin resistance is present in nearly half of HIV-infected patients in Cameroon despite a low prevalence rate of diabetes, and is associated with obesity. DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Lipids in Health and Disease LK - https://open.uct.ac.za PY - 2017 SM - 1476-511X T1 - Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon TI - Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon UR - http://hdl.handle.net/11427/34551 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34551
dc.identifier.vancouvercitationNoumegni SRN, Nansseu JR, Ama VJM, Bigna JJ, Assah FK, Guewo-Fokeng M, et al. Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon. Lipids in Health and Disease. 2017;16(1):174 - 177. http://hdl.handle.net/11427/34551.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceLipids in Health and Disease
dc.source.journalissue1
dc.source.journalvolume16
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s12944-017-0543-1
dc.subject.otherCameroon
dc.subject.otherHIV
dc.subject.otherHOMA-IR
dc.subject.otherInsulin resistance
dc.subject.otherAdult
dc.subject.otherAnti-HIV Agents
dc.subject.otherAntiretroviral Therapy, Highly Active
dc.subject.otherCameroon
dc.subject.otherCholesterol, HDL
dc.subject.otherCholesterol, LDL
dc.subject.otherCross-Sectional Studies
dc.subject.otherDiabetes Mellitus, Type 2
dc.subject.otherFemale
dc.subject.otherHIV Infections
dc.subject.otherHumans
dc.subject.otherInsulin Resistance
dc.subject.otherMale
dc.subject.otherMiddle Aged
dc.titleInsulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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