World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs

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dc.contributor.authorPrice, Ricen_ZA
dc.contributor.authorDorsey, Granten_ZA
dc.contributor.authorAshley, Elizabethen_ZA
dc.contributor.authorBarnes, Karenen_ZA
dc.contributor.authorBaird, J Kevinen_ZA
dc.contributor.authord'Alessandro, Umbertoen_ZA
dc.contributor.authorGuerin, Philippeen_ZA
dc.contributor.authorLaufer, Miriamen_ZA
dc.contributor.authorNaidoo, Inbaranien_ZA
dc.contributor.authorNosten, Francoisen_ZA
dc.contributor.authorOlliaro, Pieroen_ZA
dc.contributor.authorPlowe, Christopheren_ZA
dc.contributor.authorRingwald, Pascalen_ZA
dc.contributor.authorSibley, Carolen_ZA
dc.contributor.authorStepniewskaen_ZA
dc.date.accessioned2015-10-12T11:00:03Z
dc.date.available2015-10-12T11:00:03Z
dc.date.issued2007en_ZA
dc.description.abstractThe proliferation of antimalarial drug trials in the last ten years provides the opportunity to launch a concerted global surveillance effort to monitor antimalarial drug efficacy. The diversity of clinical study designs and analytical methods undermines the current ability to achieve this. The proposed World Antimalarial Resistance Network (WARN) aims to establish a comprehensive clinical database from which standardised estimates of antimalarial efficacy can be derived and monitored over time from diverse geographical and endemic regions. The emphasis of this initiative is on five key variables which define the therapeutic response. Ensuring that these data are collected at the individual patient level in a consistent format will facilitate better data management and analytical practices, and ensure that clinical data can be readily collated and made amenable for pooled analyses. Such an approach, if widely adopted will permit accurate and timely recognition of trends in drug efficacy. This will guide not only appropriate interventions to deal with established multidrug resistant strains of malaria, but also facilitate prompt action when new strains of drug resistant plasmodia first emerge. A comprehensive global database incorporating the key determinants of the clinical response with in vitro, molecular and pharmacokinetic parameters will bring together relevant data on host, drug and parasite factors that are fundamental contributors to treatment efficacy. This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed.en_ZA
dc.identifier.apacitationPrice, R., Dorsey, G., Ashley, E., Barnes, K., Baird, J. K., d'Alessandro, U., ... (2007). World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs. <i>Malaria Journal</i>, http://hdl.handle.net/11427/14204en_ZA
dc.identifier.chicagocitationPrice, Ric, Grant Dorsey, Elizabeth Ashley, Karen Barnes, J Kevin Baird, Umberto d'Alessandro, Philippe Guerin, et al "World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs." <i>Malaria Journal</i> (2007) http://hdl.handle.net/11427/14204en_ZA
dc.identifier.citationPrice, R. N., Dorsey, G., Ashley, E. A., Barnes, K. I., Baird, J. K., d'Alessandro, U., ... & White, N. J. (2007). World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs. Malaria journal, 6(1), 119.en_ZA
dc.identifier.ris TY - Journal Article AU - Price, Ric AU - Dorsey, Grant AU - Ashley, Elizabeth AU - Barnes, Karen AU - Baird, J Kevin AU - d'Alessandro, Umberto AU - Guerin, Philippe AU - Laufer, Miriam AU - Naidoo, Inbarani AU - Nosten, Francois AU - Olliaro, Piero AU - Plowe, Christopher AU - Ringwald, Pascal AU - Sibley, Carol AU - Stepniewska AB - The proliferation of antimalarial drug trials in the last ten years provides the opportunity to launch a concerted global surveillance effort to monitor antimalarial drug efficacy. The diversity of clinical study designs and analytical methods undermines the current ability to achieve this. The proposed World Antimalarial Resistance Network (WARN) aims to establish a comprehensive clinical database from which standardised estimates of antimalarial efficacy can be derived and monitored over time from diverse geographical and endemic regions. The emphasis of this initiative is on five key variables which define the therapeutic response. Ensuring that these data are collected at the individual patient level in a consistent format will facilitate better data management and analytical practices, and ensure that clinical data can be readily collated and made amenable for pooled analyses. Such an approach, if widely adopted will permit accurate and timely recognition of trends in drug efficacy. This will guide not only appropriate interventions to deal with established multidrug resistant strains of malaria, but also facilitate prompt action when new strains of drug resistant plasmodia first emerge. A comprehensive global database incorporating the key determinants of the clinical response with in vitro, molecular and pharmacokinetic parameters will bring together relevant data on host, drug and parasite factors that are fundamental contributors to treatment efficacy. This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed. DA - 2007 DB - OpenUCT DP - University of Cape Town J1 - Malaria Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs TI - World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs UR - http://hdl.handle.net/11427/14204 ER - en_ZA
dc.identifier.uri10.1186/1475-2875-6-119en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14204
dc.identifier.vancouvercitationPrice R, Dorsey G, Ashley E, Barnes K, Baird JK, d'Alessandro U, et al. World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs. Malaria Journal. 2007; http://hdl.handle.net/11427/14204.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceMalaria Journalen_ZA
dc.source.urihttp://www.malariajournal.com/en_ZA
dc.subject.otherMalariaen_ZA
dc.subject.otherClinical Pharmacologyen_ZA
dc.titleWorld Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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