Pseudomonas aeruginosa bloodstream infection at a tertiary referral hospital for children
| dc.contributor.author | Dame, Joycelyn A | |
| dc.contributor.author | Beylis, Natalie | |
| dc.contributor.author | Nuttall, James | |
| dc.contributor.author | Eley, Brian | |
| dc.date.accessioned | 2021-06-29T16:55:39Z | |
| dc.date.available | 2021-06-29T16:55:39Z | |
| dc.date.issued | 2020-10-07 | |
| dc.date.updated | 2020-10-11T03:21:51Z | |
| dc.description.abstract | Background This study describes the disease burden, clinical characteristics, antibiotic management, impact of multidrug resistance and outcome of Pseudomonas aeruginosa bloodstream infection (PABSI) among children admitted to a tertiary referral hospital for children in Cape Town, South Africa. Methods A retrospective descriptive study was conducted at a paediatric referral hospital in Cape Town, South Africa. Demographic and clinical details, antibiotic management and patient outcome information were extracted from medical and laboratory records. Antibiotic susceptibility results of identified organisms were obtained from the National Health Laboratory Service database. Results The incidence risk of PABSI was 5.4 (95% CI: 4.34–6.54) PABSI episodes / 10,000 hospital admissions and the most common presenting feature was respiratory distress, 34/91 (37.4%). Overall, 69/91 (75.8%) of the PA isolates were susceptible to all antipseudomonal antibiotic classes evaluated. Fifty (54.9%) of the PABSI episodes were treated with appropriate empiric antibiotic therapy. The mortality rate was 24.2% and in multivariable analysis, empiric antibiotic therapy to which PA isolates were not susceptible, infections present on admission, and not being in the intensive care unit at the time that PABSI was diagnosed were significantly associated with 14-day mortality. Conclusions PABSI caused appreciable mortality, however, appropriate empiric antibiotic therapy was associated with reduced 14-day mortality. | |
| dc.identifier.ris | TY - AU - Dame, Joycelyn A AU - Beylis, Natalie AU - Nuttall, James AU - Eley, Brian AB - Background This study describes the disease burden, clinical characteristics, antibiotic management, impact of multidrug resistance and outcome of Pseudomonas aeruginosa bloodstream infection (PABSI) among children admitted to a tertiary referral hospital for children in Cape Town, South Africa. Methods A retrospective descriptive study was conducted at a paediatric referral hospital in Cape Town, South Africa. Demographic and clinical details, antibiotic management and patient outcome information were extracted from medical and laboratory records. Antibiotic susceptibility results of identified organisms were obtained from the National Health Laboratory Service database. Results The incidence risk of PABSI was 5.4 (95% CI: 4.34–6.54) PABSI episodes / 10,000 hospital admissions and the most common presenting feature was respiratory distress, 34/91 (37.4%). Overall, 69/91 (75.8%) of the PA isolates were susceptible to all antipseudomonal antibiotic classes evaluated. Fifty (54.9%) of the PABSI episodes were treated with appropriate empiric antibiotic therapy. The mortality rate was 24.2% and in multivariable analysis, empiric antibiotic therapy to which PA isolates were not susceptible, infections present on admission, and not being in the intensive care unit at the time that PABSI was diagnosed were significantly associated with 14-day mortality. Conclusions PABSI caused appreciable mortality, however, appropriate empiric antibiotic therapy was associated with reduced 14-day mortality. DA - 2020-10-07 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Infectious Diseases KW - Pseudomonas aeruginosa bloodstream infection KW - Children KW - Sub-Saharan Africa LK - https://open.uct.ac.za PY - 2020 T1 - Pseudomonas aeruginosa bloodstream infection at a tertiary referral hospital for children TI - Pseudomonas aeruginosa bloodstream infection at a tertiary referral hospital for children UR - http://hdl.handle.net/11427/33416 ER - | en_ZA |
| dc.identifier.uri | https://doi.org/10.1186/s12879-020-05437-1 | |
| dc.identifier.uri | http://hdl.handle.net/11427/33416 | |
| dc.language.rfc3066 | en | |
| dc.rights.holder | The Author(s) | |
| dc.source | BMC Infectious Diseases | |
| dc.source.journalissue | 1 | |
| dc.source.journalvolume | 20 | |
| dc.source.pagination | 729 | |
| dc.source.uri | https://bmcinfectdis.biomedcentral.com/ | |
| dc.subject | Pseudomonas aeruginosa bloodstream infection | |
| dc.subject | Children | |
| dc.subject | Sub-Saharan Africa | |
| dc.title | Pseudomonas aeruginosa bloodstream infection at a tertiary referral hospital for children |