Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial

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dc.contributor.authorMorgan, Barak
dc.contributor.authorFearon, Pasco
dc.contributor.authorTomlinson, Mark
dc.date.accessioned2021-10-08T07:15:52Z
dc.date.available2021-10-08T07:15:52Z
dc.date.issued2017
dc.description.abstractClear recognition of the damaging effects of poverty on early childhood development has fueled an interest in interventions aimed at mitigating these harmful consequences. Psychosocial interventions aimed at alleviating the negative impacts of poverty on children are frequently shown to be of benefit, but effect sizes are typically small to moderate. However, averaging outcomes over an entire sample, as is typically done, could underestimate efficacy because weaker effects on less susceptible individuals would dilute estimation of effects on those more disposed to respond. This study investigates whether a genetic polymorphism of the serotonin transporter gene moderates susceptibility to a psychosocial intervention.
dc.identifier.apacitationMorgan, B., Fearon, P., & Tomlinson, M. (2017). Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial. <i>PLoS Medicine</i>, 14(2), e1002237 - 177. http://hdl.handle.net/11427/34713en_ZA
dc.identifier.chicagocitationMorgan, Barak, Pasco Fearon, and Mark Tomlinson "Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial." <i>PLoS Medicine</i> 14, 2. (2017): e1002237 - 177. http://hdl.handle.net/11427/34713en_ZA
dc.identifier.citationMorgan, B., Fearon, P. & Tomlinson, M. 2017. Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial. <i>PLoS Medicine.</i> 14(2):e1002237 - 177. http://hdl.handle.net/11427/34713en_ZA
dc.identifier.issn1549-1277
dc.identifier.issn1549-1676
dc.identifier.ris TY - Journal Article AU - Morgan, Barak AU - Fearon, Pasco AU - Tomlinson, Mark AB - Clear recognition of the damaging effects of poverty on early childhood development has fueled an interest in interventions aimed at mitigating these harmful consequences. Psychosocial interventions aimed at alleviating the negative impacts of poverty on children are frequently shown to be of benefit, but effect sizes are typically small to moderate. However, averaging outcomes over an entire sample, as is typically done, could underestimate efficacy because weaker effects on less susceptible individuals would dilute estimation of effects on those more disposed to respond. This study investigates whether a genetic polymorphism of the serotonin transporter gene moderates susceptibility to a psychosocial intervention. DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 2 J1 - PLoS Medicine LK - https://open.uct.ac.za PY - 2017 SM - 1549-1277 SM - 1549-1676 T1 - Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial TI - Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial UR - http://hdl.handle.net/11427/34713 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34713
dc.identifier.vancouvercitationMorgan B, Fearon P, Tomlinson M. Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial. PLoS Medicine. 2017;14(2):e1002237 - 177. http://hdl.handle.net/11427/34713.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Psychology
dc.publisher.facultyFaculty of Humanities
dc.sourcePLoS Medicine
dc.source.journalissue2
dc.source.journalvolume14
dc.source.paginatione1002237 - 177
dc.source.urihttps://dx.doi.org/10.1371/journal.pmed.1002237
dc.subject.otherInfants
dc.subject.otherVariant genotypes
dc.subject.otherGenetic predisposition
dc.subject.otherHuman genetics
dc.subject.otherPregnancy
dc.subject.otherPsychological and psychosocial issues
dc.subject.otherAdolescents
dc.subject.otherSerotonin
dc.titleSerotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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