Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease

Simple item page
dc.contributor.authorPandya, Ankur
dc.contributor.authorYu, Yuan-Jui
dc.contributor.authorGe, Yin
dc.contributor.authorNagel, Eike
dc.contributor.authorKwong, Raymond Y
dc.contributor.authorBakar, Rafidah A
dc.contributor.authorGrizzard, John D
dc.contributor.authorMerkler, Alexander E
dc.contributor.authorNtusi, Ntobeko
dc.contributor.authorPetersen, Steffen E
dc.contributor.authorRashedi, Nina
dc.contributor.authorSchwitter, Juerg
dc.contributor.authorSelvanayagam, Joseph B.
dc.contributor.authorWhite, James A.
dc.contributor.authorCarr, James
dc.contributor.authorRaman, Subha V
dc.contributor.authorSimonetti, Orlando P
dc.contributor.authorBucciarelli-Ducci, Chiara
dc.contributor.authorSierra-Galan, Lilia M
dc.contributor.authorFerrari, Victor A
dc.contributor.authorBhatia, Mona
dc.contributor.authorKelle, Sebastian
dc.date.accessioned2022-04-06T06:25:29Z
dc.date.available2022-04-06T06:25:29Z
dc.date.issued2022-01-06
dc.date.updated2022-01-09T04:09:10Z
dc.description.abstractBackground Although prior reports have evaluated the clinical and cost impacts of cardiovascular magnetic resonance (CMR) for low-to-intermediate-risk patients with suspected significant coronary artery disease (CAD), the cost-effectiveness of CMR compared to relevant comparators remains poorly understood. We aimed to summarize the cost-effectiveness literature on CMR for CAD and create a cost-effectiveness calculator, useable worldwide, to approximate the cost-per-quality-adjusted-life-year (QALY) of CMR and relevant comparators with context-specific patient-level and system-level inputs. Methods We searched the Tufts Cost-Effectiveness Analysis Registry and PubMed for cost-per-QALY or cost-per-life-year-saved studies of CMR to detect significant CAD. We also developed a linear regression meta-model (CMR Cost-Effectiveness Calculator) based on a larger CMR cost-effectiveness simulation model that can approximate CMR lifetime discount cost, QALY, and cost effectiveness compared to relevant comparators [such as single-photon emission computed tomography (SPECT), coronary computed tomography angiography (CCTA)] or invasive coronary angiography. Results CMR was cost-effective for evaluation of significant CAD (either health-improving and cost saving or having a cost-per-QALY or cost-per-life-year result lower than the cost-effectiveness threshold) versus its relevant comparator in 10 out of 15 studies, with 3 studies reporting uncertain cost effectiveness, and 2 studies showing CCTA was optimal. Our cost-effectiveness calculator showed that CCTA was not cost-effective in the US compared to CMR when the most recent publications on imaging performance were included in the model. Conclusions Based on current world-wide evidence in the literature, CMR usually represents a cost-effective option compared to relevant comparators to assess for significant CAD.en_US
dc.identifier.apacitationPandya, A., Yu, Y., Ge, Y., Nagel, E., Kwong, R. Y., Bakar, R. A., ... Kelle, S. (2022). Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease. <i>Journal of Cardiovascular Magnetic Resonance</i>, 24(1), 1. http://hdl.handle.net/11427/36274en_ZA
dc.identifier.chicagocitationPandya, Ankur, Yuan-Jui Yu, Yin Ge, Eike Nagel, Raymond Y Kwong, Rafidah A Bakar, John D Grizzard, et al "Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease." <i>Journal of Cardiovascular Magnetic Resonance</i> 24, 1. (2022): 1. http://hdl.handle.net/11427/36274en_ZA
dc.identifier.citationPandya, A., Yu, Y., Ge, Y., Nagel, E., Kwong, R.Y., Bakar, R.A., Grizzard, J.D. & Merkler, A.E. et al. 2022. Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease. <i>Journal of Cardiovascular Magnetic Resonance.</i> 24(1):1. http://hdl.handle.net/11427/36274en_ZA
dc.identifier.ris TY - Journal Article AU - Pandya, Ankur AU - Yu, Yuan-Jui AU - Ge, Yin AU - Nagel, Eike AU - Kwong, Raymond Y AU - Bakar, Rafidah A AU - Grizzard, John D AU - Merkler, Alexander E AU - Ntusi, Ntobeko AU - Petersen, Steffen E AU - Rashedi, Nina AU - Schwitter, Juerg AU - Selvanayagam, Joseph B. AU - White, James A. AU - Carr, James AU - Raman, Subha V AU - Simonetti, Orlando P AU - Bucciarelli-Ducci, Chiara AU - Sierra-Galan, Lilia M AU - Ferrari, Victor A AU - Bhatia, Mona AU - Kelle, Sebastian AB - Background Although prior reports have evaluated the clinical and cost impacts of cardiovascular magnetic resonance (CMR) for low-to-intermediate-risk patients with suspected significant coronary artery disease (CAD), the cost-effectiveness of CMR compared to relevant comparators remains poorly understood. We aimed to summarize the cost-effectiveness literature on CMR for CAD and create a cost-effectiveness calculator, useable worldwide, to approximate the cost-per-quality-adjusted-life-year (QALY) of CMR and relevant comparators with context-specific patient-level and system-level inputs. Methods We searched the Tufts Cost-Effectiveness Analysis Registry and PubMed for cost-per-QALY or cost-per-life-year-saved studies of CMR to detect significant CAD. We also developed a linear regression meta-model (CMR Cost-Effectiveness Calculator) based on a larger CMR cost-effectiveness simulation model that can approximate CMR lifetime discount cost, QALY, and cost effectiveness compared to relevant comparators [such as single-photon emission computed tomography (SPECT), coronary computed tomography angiography (CCTA)] or invasive coronary angiography. Results CMR was cost-effective for evaluation of significant CAD (either health-improving and cost saving or having a cost-per-QALY or cost-per-life-year result lower than the cost-effectiveness threshold) versus its relevant comparator in 10 out of 15 studies, with 3 studies reporting uncertain cost effectiveness, and 2 studies showing CCTA was optimal. Our cost-effectiveness calculator showed that CCTA was not cost-effective in the US compared to CMR when the most recent publications on imaging performance were included in the model. Conclusions Based on current world-wide evidence in the literature, CMR usually represents a cost-effective option compared to relevant comparators to assess for significant CAD. DA - 2022-01-06 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Journal of Cardiovascular Magnetic Resonance KW - Cost-effectiveness KW - Cardiovascular magnetic resonance KW - Coronary artery disease LK - https://open.uct.ac.za PY - 2022 T1 - Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease TI - Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease UR - http://hdl.handle.net/11427/36274 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s12968-021-00833-1
dc.identifier.urihttp://hdl.handle.net/11427/36274
dc.identifier.vancouvercitationPandya A, Yu Y, Ge Y, Nagel E, Kwong RY, Bakar RA, et al. Evidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery disease. Journal of Cardiovascular Magnetic Resonance. 2022;24(1):1. http://hdl.handle.net/11427/36274.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceJournal of Cardiovascular Magnetic Resonanceen_US
dc.source.journalissue1en_US
dc.source.journalvolume24en_US
dc.source.pagination1en_US
dc.source.urihttps://jcmr-online.biomedcentral.com/
dc.subjectCost-effectivenessen_US
dc.subjectCardiovascular magnetic resonanceen_US
dc.subjectCoronary artery diseaseen_US
dc.titleEvidence-based cardiovascular magnetic resonance cost-effectiveness calculator for the detection of significant coronary artery diseaseen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
12968_2021_Article_833.pdf
Size:
1.36 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles