Hyperglycaemic crisis in the Eastern Cape province of South Africa: High mortality and association of hyperosmolar ketoacidosis with a new diagnosis of diabetes
| dc.contributor.author | Ekpebegh, C O | |
| dc.contributor.author | Longo-Mbenza, B | |
| dc.contributor.author | Akinrinmade, A | |
| dc.contributor.author | Blanco-Blanco, E | |
| dc.contributor.author | Badri, Motasim | |
| dc.contributor.author | Levitt, N S | |
| dc.date.accessioned | 2017-06-27T08:57:34Z | |
| dc.date.available | 2017-06-27T08:57:34Z | |
| dc.date.issued | 2010 | |
| dc.date.updated | 2016-01-12T03:58:59Z | |
| dc.description.abstract | Objectives. To describe the frequencies, presenting characteristics (demographic, clinical and biochemical) and outcomes (duration of admission and mortality rates) for various types of hyperglycaemic crisis. Methods. Retrospective review of medical records of patients with hyperglycaemic crisis admitted to Nelson Mandela Academic Hospital, Mthatha, E Cape, from 1 January 2008 to 31 December 2009. Outcome measures were duration of admission and mortality. Results. Data were available for 269 admissions (response rate 81.0%), 169 females and 100 males. Admissions for hyperglycaemia (HG, N=119), and non-hyperosmolar diabetic ketoacidosis (NHDKA, N=97) were more frequent than those for hyperosmolar hyperglycaemic state (HHS, N=29) and hyperosmolar diabetic ketoacidosis (HDKA, N=24). Duration of admission was similar in all groups. Mortality was high in all groups, but was higher in patients with HDKA (37.5%, risk ratio (RR) 3.88, 95% confidence interval (CI) 1.41 - 10.67, p=0.009), HHS (31.0%, RR 2.91, 95% CI 1.09 - 7.75, p=0.033) and HG (19.5%, RR 1.56, 95% CI 0.75 - 3.21, p=0.236) than in those with NHDKA (13.4%). HDKA (62.5%) was associated with new-onset diabetes more often than NHDKA (27.8%), HHS (44.8%) or HG (17.6%) (p<0.0001). An altered level of consciousness was more frequent in HDKA than NHDKA admissions (RR 5.71, 95% CI 1.90 – 17.17, p=0.002). | |
| dc.identifier.apacitation | Ekpebegh, C. O., Longo-Mbenza, B., Akinrinmade, A., Blanco-Blanco, E., Badri, M., & Levitt, N. S. (2010). Hyperglycaemic crisis in the Eastern Cape province of South Africa: High mortality and association of hyperosmolar ketoacidosis with a new diagnosis of diabetes. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/24648 | en_ZA |
| dc.identifier.chicagocitation | Ekpebegh, C O, B Longo-Mbenza, A Akinrinmade, E Blanco-Blanco, Motasim Badri, and N S Levitt "Hyperglycaemic crisis in the Eastern Cape province of South Africa: High mortality and association of hyperosmolar ketoacidosis with a new diagnosis of diabetes." <i>South African Medical Journal</i> (2010) http://hdl.handle.net/11427/24648 | en_ZA |
| dc.identifier.citation | Ekpebegh, C. O., Longo-Mbenza, B., Akinrinmade, A., Blanco-Blanco, E., Badri, M., & Levitt, N. S. (2010). Hyperglycaemic crisis in the Eastern Cape province of South Africa: High mortality and association of hyperosmolar ketoacidosis with a new diagnosis of diabetes. SAMJ: South African Medical Journal, 100(12), 822-826. | |
| dc.identifier.ris | TY - Journal Article AU - Ekpebegh, C O AU - Longo-Mbenza, B AU - Akinrinmade, A AU - Blanco-Blanco, E AU - Badri, Motasim AU - Levitt, N S AB - Objectives. To describe the frequencies, presenting characteristics (demographic, clinical and biochemical) and outcomes (duration of admission and mortality rates) for various types of hyperglycaemic crisis. Methods. Retrospective review of medical records of patients with hyperglycaemic crisis admitted to Nelson Mandela Academic Hospital, Mthatha, E Cape, from 1 January 2008 to 31 December 2009. Outcome measures were duration of admission and mortality. Results. Data were available for 269 admissions (response rate 81.0%), 169 females and 100 males. Admissions for hyperglycaemia (HG, N=119), and non-hyperosmolar diabetic ketoacidosis (NHDKA, N=97) were more frequent than those for hyperosmolar hyperglycaemic state (HHS, N=29) and hyperosmolar diabetic ketoacidosis (HDKA, N=24). Duration of admission was similar in all groups. Mortality was high in all groups, but was higher in patients with HDKA (37.5%, risk ratio (RR) 3.88, 95% confidence interval (CI) 1.41 - 10.67, p=0.009), HHS (31.0%, RR 2.91, 95% CI 1.09 - 7.75, p=0.033) and HG (19.5%, RR 1.56, 95% CI 0.75 - 3.21, p=0.236) than in those with NHDKA (13.4%). HDKA (62.5%) was associated with new-onset diabetes more often than NHDKA (27.8%), HHS (44.8%) or HG (17.6%) (p<0.0001). An altered level of consciousness was more frequent in HDKA than NHDKA admissions (RR 5.71, 95% CI 1.90 – 17.17, p=0.002). DA - 2010 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Hyperglycaemic crisis in the Eastern Cape province of South Africa: High mortality and association of hyperosmolar ketoacidosis with a new diagnosis of diabetes TI - Hyperglycaemic crisis in the Eastern Cape province of South Africa: High mortality and association of hyperosmolar ketoacidosis with a new diagnosis of diabetes UR - http://hdl.handle.net/11427/24648 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/24648 | |
| dc.identifier.vancouvercitation | Ekpebegh CO, Longo-Mbenza B, Akinrinmade A, Blanco-Blanco E, Badri M, Levitt NS. Hyperglycaemic crisis in the Eastern Cape province of South Africa: High mortality and association of hyperosmolar ketoacidosis with a new diagnosis of diabetes. South African Medical Journal. 2010; http://hdl.handle.net/11427/24648. | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | Department of Medicine | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | South African Medical Journal | |
| dc.source.uri | http://www.samj.org.za/index.php/samj | |
| dc.title | Hyperglycaemic crisis in the Eastern Cape province of South Africa: High mortality and association of hyperosmolar ketoacidosis with a new diagnosis of diabetes | |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |