Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period
| dc.contributor.advisor | De Lacy, Ronalda Jacqueline | |
| dc.contributor.advisor | Radebe, Lindokuhle | |
| dc.contributor.advisor | Brown, Robin | |
| dc.contributor.author | Mokoto, Tshepang | |
| dc.date.accessioned | 2026-01-23T10:53:38Z | |
| dc.date.available | 2026-01-23T10:53:38Z | |
| dc.date.issued | 2025 | |
| dc.date.updated | 2026-01-23T07:22:04Z | |
| dc.description.abstract | Background: Liver biopsy is a fundamental diagnostic tool in clinical hepatology, also playing a crucial role in the prognostication and management of liver diseases. Previous studies at various centres have examined liver biopsies in the context of liver disease workups, including indications, histological findings and procedural complications. Objectives: To ascertain the role of liver biopsy in the evaluation of patients with liver diseases at Red Cross War Memorial Children's Hospital (RCWMCH) over a six-year period. Method: This retrospective descriptive study includes all paediatric patients who underwent liver biopsies at RCWMCH between 01/01/2018 and 30/06/2023. Results: Seventy-five patients were screened for eligibility; six were excluded due to missing data and files, subsequently the study comprised of sixty-nine participants. Most liver biopsies were performed percutaneously under ultrasound guidance (n=45, 65%). There were three (4.3%) major complications, and no minor complication. The tissue yield was 95.7% (n = 66), with histopathological findings guiding clinical management in 50 patients (72%). Most frequent diagnoses were biliary atresia and autoimmune hepatitis. The commonest indications for liver biopsy were hyperbilirubinemia and suspected graft rejection. Conclusion: Although liver biopsy is an invasive procedure, if guidelines are adhered to and performed by experienced staff it can be justified when using standard indications as it has a low complication rate in our setting and directly influence management in the majority of cases | |
| dc.identifier.apacitation | Mokoto, T. (2025). <i>Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/42661 | en_ZA |
| dc.identifier.chicagocitation | Mokoto, Tshepang. <i>"Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2025. http://hdl.handle.net/11427/42661 | en_ZA |
| dc.identifier.citation | Mokoto, T. 2025. Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period. . University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. http://hdl.handle.net/11427/42661 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Mokoto, Tshepang AB - Background: Liver biopsy is a fundamental diagnostic tool in clinical hepatology, also playing a crucial role in the prognostication and management of liver diseases. Previous studies at various centres have examined liver biopsies in the context of liver disease workups, including indications, histological findings and procedural complications. Objectives: To ascertain the role of liver biopsy in the evaluation of patients with liver diseases at Red Cross War Memorial Children's Hospital (RCWMCH) over a six-year period. Method: This retrospective descriptive study includes all paediatric patients who underwent liver biopsies at RCWMCH between 01/01/2018 and 30/06/2023. Results: Seventy-five patients were screened for eligibility; six were excluded due to missing data and files, subsequently the study comprised of sixty-nine participants. Most liver biopsies were performed percutaneously under ultrasound guidance (n=45, 65%). There were three (4.3%) major complications, and no minor complication. The tissue yield was 95.7% (n = 66), with histopathological findings guiding clinical management in 50 patients (72%). Most frequent diagnoses were biliary atresia and autoimmune hepatitis. The commonest indications for liver biopsy were hyperbilirubinemia and suspected graft rejection. Conclusion: Although liver biopsy is an invasive procedure, if guidelines are adhered to and performed by experienced staff it can be justified when using standard indications as it has a low complication rate in our setting and directly influence management in the majority of cases DA - 2025 DB - OpenUCT DP - University of Cape Town KW - Liver KW - Red Cross War Memorial Children's Hospital LK - https://open.uct.ac.za PB - University of Cape Town PY - 2025 T1 - Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period TI - Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period UR - http://hdl.handle.net/11427/42661 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/42661 | |
| dc.identifier.vancouvercitation | Mokoto T. Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period. []. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2025 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/42661 | en_ZA |
| dc.language.iso | en | |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Paediatrics and Child Health | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.publisher.institution | University of Cape Town | |
| dc.subject | Liver | |
| dc.subject | Red Cross War Memorial Children's Hospital | |
| dc.title | Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period | |
| dc.type | Thesis / Dissertation | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | Masters |