Metabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes?

Simple item page
dc.contributor.advisorReed, Cecile Cen_ZA
dc.contributor.advisorKohn, Tertiusen_ZA
dc.contributor.authorVan Velden, Juliaen_ZA
dc.date.accessioned2014-09-22T12:00:09Z
dc.date.available2014-09-22T12:00:09Z
dc.date.issued2013en_ZA
dc.description.abstractThe Chacma baboons (Papio ursinus) of the Cape Peninsula are established raiders of human food, leading to widespread conflict between this intelligent, adaptable species and humans. The modern Western diet that these baboons have become exposed to has many deleterious effects on health, including obesity and type 2 diabetes. The aim of this study was to investigate whether this population of baboons have lowered GLUT-­‐4 transporter protein levels in comparison to wild-­‐feeding baboons, as an indication of insulin abnormalities. GLUT-­‐4 levels were analysed via Western Blot and DXA scanning was used to compare physical characteristics between these two groups. No significant difference in GLUT-­‐4 levels was found, however the two groups differed in three physical variables, with the semi-­‐provisioned Peninsula group having higher total weight (kg)(p<0,05), total body lean mass (kg) (p<0,01) and bone mineral content (kg)(p<0,001) than the wild-­‐feeding controls. These results indicate that male individuals from the Peninsula population are bigger but not fatter than wild-­‐feeding male baboons from the Eastern Cape population. Although it could not be determined whether human food is causing insulin abnormalities in the Cape Peninsula’s population of Chacma baboons, this study indicates that this is a promising area of research, likely to affect the management strategies used on this population.en_ZA
dc.identifier.apacitationVan Velden, J. (2013). <i>Metabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes?</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Biological Sciences. Retrieved from http://hdl.handle.net/11427/7626en_ZA
dc.identifier.chicagocitationVan Velden, Julia. <i>"Metabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes?."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Biological Sciences, 2013. http://hdl.handle.net/11427/7626en_ZA
dc.identifier.citationVan Velden, J. 2013. Metabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes?. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Van Velden, Julia AB - The Chacma baboons (Papio ursinus) of the Cape Peninsula are established raiders of human food, leading to widespread conflict between this intelligent, adaptable species and humans. The modern Western diet that these baboons have become exposed to has many deleterious effects on health, including obesity and type 2 diabetes. The aim of this study was to investigate whether this population of baboons have lowered GLUT-­‐4 transporter protein levels in comparison to wild-­‐feeding baboons, as an indication of insulin abnormalities. GLUT-­‐4 levels were analysed via Western Blot and DXA scanning was used to compare physical characteristics between these two groups. No significant difference in GLUT-­‐4 levels was found, however the two groups differed in three physical variables, with the semi-­‐provisioned Peninsula group having higher total weight (kg)(p&lt;0,05), total body lean mass (kg) (p&lt;0,01) and bone mineral content (kg)(p&lt;0,001) than the wild-­‐feeding controls. These results indicate that male individuals from the Peninsula population are bigger but not fatter than wild-­‐feeding male baboons from the Eastern Cape population. Although it could not be determined whether human food is causing insulin abnormalities in the Cape Peninsula’s population of Chacma baboons, this study indicates that this is a promising area of research, likely to affect the management strategies used on this population. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Metabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes? TI - Metabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes? UR - http://hdl.handle.net/11427/7626 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/7626
dc.identifier.vancouvercitationVan Velden J. Metabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes?. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Biological Sciences, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/7626en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Biological Sciencesen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleMetabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes?en_ZA
dc.typeBachelor Thesis
dc.type.qualificationlevelHonours
dc.type.qualificationnameBScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_sci_2013_van_velden_baboon_diabetes.pdf
Size:
23.61 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Other Theses