The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol

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dc.contributor.authorMuloiwa, Rudzani
dc.contributor.authorKagina, Benjamin M
dc.contributor.authorEngel, Mark E
dc.contributor.authorHussey, Gregory D
dc.date.accessioned2015-07-30T04:12:15Z
dc.date.available2015-07-30T04:12:15Z
dc.date.issued2015-05-01
dc.date.updated2015-05-05T18:01:14Z
dc.description.abstractAbstract Background Vaccine against pertussis has been in use for several decades. Despite the widespread use of pertussis vaccine, evidence shows resurgence of pertussis in high-income countries. Pertussis surveillance data is largely missing from low- and middle-income countries (LMICs). Without data on trends of pertussis, it is difficult to review and amend pertussis control policies in any country. We propose conducting a systematic review to evaluate the burden and trends of pertussis in LMICs since 1974. Methods/design Common and medical subject heading (MeSH) terms for pertussis and LMICs will be used to search electronic databases for the relevant literature published between 1974 and December 2014. Only studies from LMICs that fulfils World Health Organisation (WHO) or CDC pertussis case definitions will be included. The studies must have a clear numerator and denominator in a well-defined population. Risk of bias will be evaluated by assessing all qualifying full-text articles for quality and eligibility using a modified quality score assessment tool. Standardised data extraction will be carried out after which descriptions of trends in the prevalence, incidence, as well as mortality rate and case fatality rate, will be done. Where sufficient data is available, the results will be stratified by age group, geography, location, vaccination and HIV status. Discussion The systematic review proposed by this protocol seeks to address the knowledge gap in the epidemiology of pertussis in LMICs for the first time. It is anticipated that the background epidemiological trends of pertussis in LMICs that our study will provide could be used in the planning for the control of pertussis. Systematic review registration PROSPERO CRD42015015159
dc.identifier.apacitationMuloiwa, R., Kagina, B. M., Engel, M. E., & Hussey, G. D. (2015). The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol. <i>Systematic Reviews</i>, http://hdl.handle.net/11427/13633en_ZA
dc.identifier.chicagocitationMuloiwa, Rudzani, Benjamin M Kagina, Mark E Engel, and Gregory D Hussey "The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol." <i>Systematic Reviews</i> (2015) http://hdl.handle.net/11427/13633en_ZA
dc.identifier.citationMuloiwa, R., Kagina, B. M., Engel, M. E., & Hussey, G. D. (2015). The burden of pertussis in low-and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol. Systematic reviews, 4(1), 62.
dc.identifier.ris TY - Journal Article AU - Muloiwa, Rudzani AU - Kagina, Benjamin M AU - Engel, Mark E AU - Hussey, Gregory D AB - Abstract Background Vaccine against pertussis has been in use for several decades. Despite the widespread use of pertussis vaccine, evidence shows resurgence of pertussis in high-income countries. Pertussis surveillance data is largely missing from low- and middle-income countries (LMICs). Without data on trends of pertussis, it is difficult to review and amend pertussis control policies in any country. We propose conducting a systematic review to evaluate the burden and trends of pertussis in LMICs since 1974. Methods/design Common and medical subject heading (MeSH) terms for pertussis and LMICs will be used to search electronic databases for the relevant literature published between 1974 and December 2014. Only studies from LMICs that fulfils World Health Organisation (WHO) or CDC pertussis case definitions will be included. The studies must have a clear numerator and denominator in a well-defined population. Risk of bias will be evaluated by assessing all qualifying full-text articles for quality and eligibility using a modified quality score assessment tool. Standardised data extraction will be carried out after which descriptions of trends in the prevalence, incidence, as well as mortality rate and case fatality rate, will be done. Where sufficient data is available, the results will be stratified by age group, geography, location, vaccination and HIV status. Discussion The systematic review proposed by this protocol seeks to address the knowledge gap in the epidemiology of pertussis in LMICs for the first time. It is anticipated that the background epidemiological trends of pertussis in LMICs that our study will provide could be used in the planning for the control of pertussis. Systematic review registration PROSPERO CRD42015015159 DA - 2015-05-01 DB - OpenUCT DO - 10.1186/s13643-015-0053-z DP - University of Cape Town J1 - Systematic Reviews LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol TI - The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol UR - http://hdl.handle.net/11427/13633 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13633
dc.identifier.urihttp://dx.doi.org/10.1186/s13643-015-0053-z
dc.identifier.vancouvercitationMuloiwa R, Kagina BM, Engel ME, Hussey GD. The burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol. Systematic Reviews. 2015; http://hdl.handle.net/11427/13633.en_ZA
dc.language.rfc3066en
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License*
dc.rights.holderMuloiwa et al.; licensee BioMed Central.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0*
dc.sourceSystematic Reviewsen_ZA
dc.source.urihttp://www.systematicreviewsjournal.com
dc.subject.otherPertussisen_ZA
dc.subject.otherWhooping coughen_ZA
dc.subject.otherBurdenen_ZA
dc.subject.otherPrevalenceen_ZA
dc.subject.otherIncidenceen_ZA
dc.subject.otherLMICsen_ZA
dc.titleThe burden of pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunization (EPI) in 1974: a systematic review protocol
dc.typeJournal Articleen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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