Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity

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dc.contributor.authorAyina Ayina, Clarisse Noël
dc.contributor.authorSobngwi, Eugène
dc.contributor.authorEssouma, Mickael
dc.contributor.authorNoubiap, Jean Jacques N
dc.contributor.authorBoudou, Philippe
dc.contributor.authorEtoundi Ngoa, Laurent Serge
dc.contributor.authorGautier, Jean François
dc.date.accessioned2021-10-08T06:55:03Z
dc.date.available2021-10-08T06:55:03Z
dc.date.issued2015
dc.description.abstractBackgroundOsteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily that inhibits bone resorption, has been suggested as a potential marker of cardiovascular risk. This study aimed to assess the relationship between insulin resistance, lipid profile and OPG levels in obese and non-obese sub-Saharan African women.MethodsSixty obese (44) and non-obese (16) volunteer women aged 18 to 40years were recruited in this cross-sectional study. Their clinical (age, height, weight, waist circumference, systolic and diastolic blood pressures) and biochemical parameters (fasting blood glucose, total cholesterol, high density lipoprotein-cholesterol (HDL-C)) were measured using standard methods. Insulin levels were measured using an electrochemiluminescence immunoassay, while OPG levels were measured using the ELISA technique. Low density lipoprotein-cholesterol (LDL-C), body mass index (BMI) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) were calculated using standard methods. Abdominal obesity was defined as a waist circumference ≥ 80cm.ResultsOPG levels were higher in obese than in normal subjects, though the difference was not significant (p = 0.9). BMI, waist circumference, percent body fat and systolic blood pressure were significantly higher in obese than in non-obese subjects (p < 0.05). In these subjects, only age significantly correlated with OPG levels (r = 0.831, p = 0.003), while none of the anthropometric nor metabolic parameter did, even after adjustment for age. In obese subjects, OPG levels fairly correlated with HDL-C (r = 0.298, p = 0.058), and significantly correlated with HOMA-IR (r = −0.438, p = 0.018). After adjustment for age, OPG levels remained negatively correlated to HOMA-IR (r = −0.516, p = 0.020) and LDL-C (r = −0.535, p = 0.015) and positively correlated to HDL-C (r = 0.615, p = 0.004). In multiple linear regression analysis, age was a main determinant of OPG levels in non-obese (β = 0.647, p = 0.006) and obese (β = 0.356, p = 0.044) women. HDL-C was also associated to OPG levels in obese women (β = 0.535, p = 0.009).ConclusionThe positive correlation of OPG with HDL-C and HOMA-IR, and its negative correlation with LDL-C suggest that it may be a marker of insulin sensitivity/resistance and atherogenic risk in obese African women.
dc.identifier.apacitationAyina Ayina, C. N., Sobngwi, E., Essouma, M., Noubiap, J. J. N., Boudou, P., Etoundi Ngoa, L. S., & Gautier, J. F. (2015). Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity. <i>Diabetology & Metabolic Syndrome</i>, 7(1), 174 - 177. http://hdl.handle.net/11427/34405en_ZA
dc.identifier.chicagocitationAyina Ayina, Clarisse Noël, Eugène Sobngwi, Mickael Essouma, Jean Jacques N Noubiap, Philippe Boudou, Laurent Serge Etoundi Ngoa, and Jean François Gautier "Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity." <i>Diabetology & Metabolic Syndrome</i> 7, 1. (2015): 174 - 177. http://hdl.handle.net/11427/34405en_ZA
dc.identifier.citationAyina Ayina, C.N., Sobngwi, E., Essouma, M., Noubiap, J.J.N., Boudou, P., Etoundi Ngoa, L.S. & Gautier, J.F. 2015. Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity. <i>Diabetology & Metabolic Syndrome.</i> 7(1):174 - 177. http://hdl.handle.net/11427/34405en_ZA
dc.identifier.issn1758-5996
dc.identifier.ris TY - Journal Article AU - Ayina Ayina, Clarisse Noël AU - Sobngwi, Eugène AU - Essouma, Mickael AU - Noubiap, Jean Jacques N AU - Boudou, Philippe AU - Etoundi Ngoa, Laurent Serge AU - Gautier, Jean François AB - BackgroundOsteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily that inhibits bone resorption, has been suggested as a potential marker of cardiovascular risk. This study aimed to assess the relationship between insulin resistance, lipid profile and OPG levels in obese and non-obese sub-Saharan African women.MethodsSixty obese (44) and non-obese (16) volunteer women aged 18 to 40years were recruited in this cross-sectional study. Their clinical (age, height, weight, waist circumference, systolic and diastolic blood pressures) and biochemical parameters (fasting blood glucose, total cholesterol, high density lipoprotein-cholesterol (HDL-C)) were measured using standard methods. Insulin levels were measured using an electrochemiluminescence immunoassay, while OPG levels were measured using the ELISA technique. Low density lipoprotein-cholesterol (LDL-C), body mass index (BMI) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) were calculated using standard methods. Abdominal obesity was defined as a waist circumference ≥ 80cm.ResultsOPG levels were higher in obese than in normal subjects, though the difference was not significant (p = 0.9). BMI, waist circumference, percent body fat and systolic blood pressure were significantly higher in obese than in non-obese subjects (p < 0.05). In these subjects, only age significantly correlated with OPG levels (r = 0.831, p = 0.003), while none of the anthropometric nor metabolic parameter did, even after adjustment for age. In obese subjects, OPG levels fairly correlated with HDL-C (r = 0.298, p = 0.058), and significantly correlated with HOMA-IR (r = −0.438, p = 0.018). After adjustment for age, OPG levels remained negatively correlated to HOMA-IR (r = −0.516, p = 0.020) and LDL-C (r = −0.535, p = 0.015) and positively correlated to HDL-C (r = 0.615, p = 0.004). In multiple linear regression analysis, age was a main determinant of OPG levels in non-obese (β = 0.647, p = 0.006) and obese (β = 0.356, p = 0.044) women. HDL-C was also associated to OPG levels in obese women (β = 0.535, p = 0.009).ConclusionThe positive correlation of OPG with HDL-C and HOMA-IR, and its negative correlation with LDL-C suggest that it may be a marker of insulin sensitivity/resistance and atherogenic risk in obese African women. DA - 2015 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Diabetology & Metabolic Syndrome LK - https://open.uct.ac.za PY - 2015 SM - 1758-5996 T1 - Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity TI - Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity UR - http://hdl.handle.net/11427/34405 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34405
dc.identifier.vancouvercitationAyina Ayina CN, Sobngwi E, Essouma M, Noubiap JJN, Boudou P, Etoundi Ngoa LS, et al. Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity. Diabetology & Metabolic Syndrome. 2015;7(1):174 - 177. http://hdl.handle.net/11427/34405.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceDiabetology & Metabolic Syndrome
dc.source.journalissue1
dc.source.journalvolume7
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s13098-015-0042-3
dc.subject.otherInsulin Resistance
dc.subject.otherBone Resorption
dc.subject.otherObesity, Abdominal
dc.subject.otherBlood
dc.subject.otherFat Body
dc.subject.otherLipids
dc.subject.otherInsulin
dc.subject.otherOsteoprotegerin
dc.subject.otherCholesterol, LDL
dc.subject.otherCholesterol, HDL
dc.subject.otherLipoproteins, HDL
dc.subject.otherCholesterol
dc.subject.otherBlood Glucose
dc.subject.otherReceptors, Tumor Necrosis Factor
dc.subject.otherHomeostasis
dc.subject.otherFasting
dc.subject.otherBody Mass Index
dc.subject.otherRisk
dc.subject.otherWaist Circumference
dc.subject.otherImmunoassay
dc.subject.otherCross-Sectional Studies
dc.subject.otherRegression Analysis
dc.subject.otherBlood Pressure
dc.subject.otherHomo sapiens
dc.subject.otherDiabetes
dc.subject.otherMetabolic Diseases
dc.titleOsteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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