Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction

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dc.contributor.authorSeoighe, Cathalen_ZA
dc.contributor.authorGehring, Chrisen_ZA
dc.contributor.authorHurst, Laurence Den_ZA
dc.date.accessioned2015-11-18T07:06:50Z
dc.date.available2015-11-18T07:06:50Z
dc.date.issued2005en_ZA
dc.description.abstractWhy do highly expressed genes have small introns? This is an important issue, not least because it provides a testing ground to compare selectionist and neutralist models of genome evolution. Some argue that small introns are selectively favoured to reduce the costs of transcription. Alternatively, large introns might permit complex regulation, not needed for highly expressed genes. This "genome design" hypothesis evokes a regionalized model of control of expression and hence can explain why intron size covaries with intergene distance, a feature also consistent with the hypothesis that highly expressed genes cluster in genomic regions with high deletion rates. As some genes are expressed in the haploid stage and hence subject to especially strong purifying selection, the evolution of genes in Arabidopsis provides a novel testing ground to discriminate between these possibilities. Importantly, controlling for expression level, genes that are expressed in pollen have shorter introns than genes that are expressed in the sporophyte. That genes flanking pollen-expressed genes have average-sized introns and intergene distances argues against regional mutational biases and genomic design. These observations thus support the view that selection for efficiency contributes to the reduction in intron length and provide the first report of a molecular signature of strong gametophytic selection.en_ZA
dc.identifier.apacitationSeoighe, C., Gehring, C., & Hurst, L. D. (2005). Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction. <i>PLOS Genetics</i>, http://hdl.handle.net/11427/15118en_ZA
dc.identifier.chicagocitationSeoighe, Cathal, Chris Gehring, and Laurence D Hurst "Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction." <i>PLOS Genetics</i> (2005) http://hdl.handle.net/11427/15118en_ZA
dc.identifier.citationSeoighe, C., Gehring, C., & Hurst, L. D. (2005). Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction. PLoS genetics, 1(2), e13-e13. doi:10.1371/journal.pgen.0010013en_ZA
dc.identifier.ris TY - Journal Article AU - Seoighe, Cathal AU - Gehring, Chris AU - Hurst, Laurence D AB - Why do highly expressed genes have small introns? This is an important issue, not least because it provides a testing ground to compare selectionist and neutralist models of genome evolution. Some argue that small introns are selectively favoured to reduce the costs of transcription. Alternatively, large introns might permit complex regulation, not needed for highly expressed genes. This "genome design" hypothesis evokes a regionalized model of control of expression and hence can explain why intron size covaries with intergene distance, a feature also consistent with the hypothesis that highly expressed genes cluster in genomic regions with high deletion rates. As some genes are expressed in the haploid stage and hence subject to especially strong purifying selection, the evolution of genes in Arabidopsis provides a novel testing ground to discriminate between these possibilities. Importantly, controlling for expression level, genes that are expressed in pollen have shorter introns than genes that are expressed in the sporophyte. That genes flanking pollen-expressed genes have average-sized introns and intergene distances argues against regional mutational biases and genomic design. These observations thus support the view that selection for efficiency contributes to the reduction in intron length and provide the first report of a molecular signature of strong gametophytic selection. DA - 2005 DB - OpenUCT DO - 10.1371/journal.pgen.0010013 DP - University of Cape Town J1 - PLOS Genetics LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction TI - Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction UR - http://hdl.handle.net/11427/15118 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15118
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pgen.0010013
dc.identifier.vancouvercitationSeoighe C, Gehring C, Hurst LD. Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction. PLOS Genetics. 2005; http://hdl.handle.net/11427/15118.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2005 Seoighe et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLOS Geneticsen_ZA
dc.source.urihttp://journals.plos.org/plosgeneticsen_ZA
dc.subject.otherIntronsen_ZA
dc.subject.otherGene expressionen_ZA
dc.subject.otherPollenen_ZA
dc.subject.otherSerial analysis of gene expressionen_ZA
dc.subject.otherGene regulationen_ZA
dc.subject.otherArabidopsis thalianaen_ZA
dc.subject.otherPlant genomicsen_ZA
dc.subject.otherDNA transcriptionen_ZA
dc.titleGametophytic selection in Arabidopsis thaliana supports the selective model of intron length reductionen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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