Natriuretic peptide-directed medical therapy: a systematic review
| dc.contributor.author | Alphonsus, Christella S | |
| dc.contributor.author | Govender, Pooveshnie | |
| dc.contributor.author | Rodseth, Reitze N | |
| dc.contributor.author | Biccard, Bruce M | |
| dc.date.accessioned | 2020-03-02T12:12:09Z | |
| dc.date.available | 2020-03-02T12:12:09Z | |
| dc.date.issued | 2020-02-18 | |
| dc.date.updated | 2020-02-23T04:31:52Z | |
| dc.description.abstract | Abstract Natriuretic peptides (NP) are strongly associated with perioperative cardiovascular events. However, in patients with raised NP, it remains unknown whether treatment to reduce NP levels prior to surgery results in better perioperative outcomes. In this systematic review and meta-analysis, we investigate NP-directed medical therapy in non-surgical patients to provide guidance for NP-directed medical therapy in surgical patients. The protocol was registered with PROSPERO (CRD42017051468). The database search included MEDLINE (PubMed), CINAHL (EBSCO host), EMBASE (EBSCO host), ProQuest, Web of Science, and Cochrane database. The primary outcome was to determine whether NP-directed medical therapy is effective in reducing NP levels within 6 months, compared to standard of care. The secondary outcome was to determine whether reducing NP levels is associated with decreased mortality. Full texts of 18 trials were reviewed. NP-directed medical therapy showed no significant difference compared to standard care in decreasing NP levels (standardized mean difference − 0.04 (− 0.16, 0.07)), but was associated with a 6-month (relative risk (RR) 0.82 (95% confidence interval (CI) 0.68–0.99)) reduction in mortality. | |
| dc.identifier.apacitation | Alphonsus, C. S., Govender, P., Rodseth, R. N., & Biccard, B. M. (2020). Natriuretic peptide-directed medical therapy: a systematic review. http://hdl.handle.net/11427/31441 | en_ZA |
| dc.identifier.chicagocitation | Alphonsus, Christella S, Pooveshnie Govender, Reitze N Rodseth, and Bruce M Biccard "Natriuretic peptide-directed medical therapy: a systematic review." (2020) http://hdl.handle.net/11427/31441 | en_ZA |
| dc.identifier.citation | Perioperative Medicine. 2020 Feb 18;9(1):5 | |
| dc.identifier.ris | TY - AU - Alphonsus, Christella S AU - Govender, Pooveshnie AU - Rodseth, Reitze N AU - Biccard, Bruce M AB - Abstract Natriuretic peptides (NP) are strongly associated with perioperative cardiovascular events. However, in patients with raised NP, it remains unknown whether treatment to reduce NP levels prior to surgery results in better perioperative outcomes. In this systematic review and meta-analysis, we investigate NP-directed medical therapy in non-surgical patients to provide guidance for NP-directed medical therapy in surgical patients. The protocol was registered with PROSPERO (CRD42017051468). The database search included MEDLINE (PubMed), CINAHL (EBSCO host), EMBASE (EBSCO host), ProQuest, Web of Science, and Cochrane database. The primary outcome was to determine whether NP-directed medical therapy is effective in reducing NP levels within 6 months, compared to standard of care. The secondary outcome was to determine whether reducing NP levels is associated with decreased mortality. Full texts of 18 trials were reviewed. NP-directed medical therapy showed no significant difference compared to standard care in decreasing NP levels (standardized mean difference − 0.04 (− 0.16, 0.07)), but was associated with a 6-month (relative risk (RR) 0.82 (95% confidence interval (CI) 0.68–0.99)) reduction in mortality. DA - 2020-02-18 DB - OpenUCT DP - University of Cape Town KW - Cardiac morbidity KW - Pre-operative evaluation KW - Myocardial ischemia LK - https://open.uct.ac.za PY - 2020 T1 - Natriuretic peptide-directed medical therapy: a systematic review TI - Natriuretic peptide-directed medical therapy: a systematic review UR - http://hdl.handle.net/11427/31441 ER - | en_ZA |
| dc.identifier.uri | https://doi.org/10.1186/s13741-019-0134-y | |
| dc.identifier.uri | http://hdl.handle.net/11427/31441 | |
| dc.identifier.vancouvercitation | Alphonsus CS, Govender P, Rodseth RN, Biccard BM. Natriuretic peptide-directed medical therapy: a systematic review. 2020; http://hdl.handle.net/11427/31441. | en_ZA |
| dc.language.rfc3066 | en | |
| dc.rights.holder | The Author(s). | |
| dc.subject | Cardiac morbidity | |
| dc.subject | Pre-operative evaluation | |
| dc.subject | Myocardial ischemia | |
| dc.title | Natriuretic peptide-directed medical therapy: a systematic review | |
| dc.type | Journal Article |