Antimalarials based on the arylpiperazine privileged substructure

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorMolyneaux, Carrie-Anneen_ZA
dc.date.accessioned2014-08-13T14:27:27Z
dc.date.available2014-08-13T14:27:27Z
dc.date.issued2005en_ZA
dc.descriptionIncludes bibliographical references (leaves 118-124).en_ZA
dc.description.abstractBased on a previous study, arylpiperazines (2-chlorophenylpiperazine, 2-ethoxyphenylpiperazine and phenylpiperazine) were found to be significantly more potent against the chloroquine-resistant (K1) strain than against the chloroquine-sensitive(DIO) strain. In other studies, 8-hydroxy-2-(di-n-propylamino)tetralin (8-0H-DPAT) has been identified as a potential antimalarial agent for the inhibition of the 5-hydroxytryptamine type 1A receptor in Plasmodium falciparum. A number of arylpiperazines are also known to target this receptor in other systems. Coupled with the potential role of arylpiperazines as replacements for the antimalarial 8-OH-OPA T, these results prompted a further investigation into the antiplasmodial properties of a broader range of simple un substituted and substituted arylpiperazines against a broader range of chloroquine-sensitive and chloroquine-resistant strains of PlasmodiumJalciparum.en_ZA
dc.identifier.apacitationMolyneaux, C. (2005). <i>Antimalarials based on the arylpiperazine privileged substructure</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6342en_ZA
dc.identifier.chicagocitationMolyneaux, Carrie-Anne. <i>"Antimalarials based on the arylpiperazine privileged substructure."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2005. http://hdl.handle.net/11427/6342en_ZA
dc.identifier.citationMolyneaux, C. 2005. Antimalarials based on the arylpiperazine privileged substructure. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Molyneaux, Carrie-Anne AB - Based on a previous study, arylpiperazines (2-chlorophenylpiperazine, 2-ethoxyphenylpiperazine and phenylpiperazine) were found to be significantly more potent against the chloroquine-resistant (K1) strain than against the chloroquine-sensitive(DIO) strain. In other studies, 8-hydroxy-2-(di-n-propylamino)tetralin (8-0H-DPAT) has been identified as a potential antimalarial agent for the inhibition of the 5-hydroxytryptamine type 1A receptor in Plasmodium falciparum. A number of arylpiperazines are also known to target this receptor in other systems. Coupled with the potential role of arylpiperazines as replacements for the antimalarial 8-OH-OPA T, these results prompted a further investigation into the antiplasmodial properties of a broader range of simple un substituted and substituted arylpiperazines against a broader range of chloroquine-sensitive and chloroquine-resistant strains of PlasmodiumJalciparum. DA - 2005 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Antimalarials based on the arylpiperazine privileged substructure TI - Antimalarials based on the arylpiperazine privileged substructure UR - http://hdl.handle.net/11427/6342 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6342
dc.identifier.vancouvercitationMolyneaux C. Antimalarials based on the arylpiperazine privileged substructure. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2005 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6342en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleAntimalarials based on the arylpiperazine privileged substructureen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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