Peripheral blood mononuclear cells as non-invasive diagnostic indicators of stress-associated neural states

Master Thesis

2008

Permanent link to this Item
http://hdl.handle.net/11427/4347
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thesis_sci_2008_van_heerden_jh.pdf (6.24 MB)
Authors
Van Heerden, Johannes Hendrik
Supervisors
Illing, Nicola
Stein, Dan
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Publisher
Publisher

University of Cape Town

Department
Department of Molecular and Cell Biology
Faculty
Faculty of Science
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Abstract
Researchers have demonstrated the ability to predict psychopathological states from human peripheral immune tissure transcriptional profiles, using microarrays. Although evidence in support of such an approach as a viable diagnostic avenue within psychiatric settings is accumulating, it remains to be demonstrated, in an animal model, that transcriptional changes in peripheral tissue targets are paralleled by specific gene expression changes in neural tissues.
Description

Includes abstract.


Includes bibliographical references (leaves 155-181).

Keywords
Molecular Biology

Reference:

Van Heerden, J. 2008. Peripheral blood mononuclear cells as non-invasive diagnostic indicators of stress-associated neural states. University of Cape Town.

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