Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora

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dc.contributor.authorCreber, Chloe
dc.contributor.authorCooper, Richard S
dc.contributor.authorPlange-Rhule, Jacob
dc.contributor.authorBovet, Pascal
dc.contributor.authorLambert, Estelle V
dc.contributor.authorForrester, Terrence E
dc.contributor.authorSchoeller, Dale
dc.contributor.authorRiesen, Walter
dc.contributor.authorKorte, Wolfgang
dc.contributor.authorCao, Guichan
dc.contributor.authorLuke, Amy
dc.contributor.authorDugas, Lara R
dc.date.accessioned2018-01-16T08:36:57Z
dc.date.available2018-01-16T08:36:57Z
dc.date.issued2018-01-10
dc.date.updated2018-01-14T04:17:08Z
dc.description.abstractBackground: Obesity is a major risk factor for hypertension, however, the physiologic mechanisms linking increased adiposity to elevations in blood pressure are not well described. An increase in resting energy expenditure (REE) is an obligatory consequence of obesity. Previous survey research has demonstrated that REE is an independent predictor of blood pressure, and eliminates the co-linear association of body mass index. This observation has received little attention and there have been no attempts to provide a causal explanation. Methods: At baseline in an international comparative study on obesity, 289 participants aged 25–44 were recruited from communities in the US, the Seychelles, Ghana and South Africa and had REE measured with indirect calorimetry. All participants were thought to be free of major illness. Results: In multivariate regression models, both systolic and diastolic blood pressure were positively associated with REE (p < 0.01), while body mass index and fat mass were negatively correlated with systolic blood pressure (p < 0.01, and p < 0.05 respectively), but not diastolic blood pressure. Conclusions: These data confirm previous reports and suggest that a common physiologic abnormality links REE and blood pressure. Elevated catecholamines, a putative metabolic characteristic of obesity, is a possible candidate to explain this association. The direct role of excess adipose tissue is open to question.
dc.identifier.apacitationCreber, C., Cooper, R. S., Plange-Rhule, J., Bovet, P., Lambert, E. V., Forrester, T. E., ... Dugas, L. R. (2018). Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora. <i>BMC Cardiovascular Disorders</i>, http://hdl.handle.net/11427/26821en_ZA
dc.identifier.chicagocitationCreber, Chloe, Richard S Cooper, Jacob Plange-Rhule, Pascal Bovet, Estelle V Lambert, Terrence E Forrester, Dale Schoeller, et al "Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora." <i>BMC Cardiovascular Disorders</i> (2018) http://hdl.handle.net/11427/26821en_ZA
dc.identifier.citationCreber, C., Cooper, R. S., Plange-Rhule, J., Bovet, P., Lambert, E. V., Forrester, T. E., ... & Luke, A. (2018). Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora. BMC Cardiovascular Disorders, 18(1), 4.
dc.identifier.ris TY - Journal Article AU - Creber, Chloe AU - Cooper, Richard S AU - Plange-Rhule, Jacob AU - Bovet, Pascal AU - Lambert, Estelle V AU - Forrester, Terrence E AU - Schoeller, Dale AU - Riesen, Walter AU - Korte, Wolfgang AU - Cao, Guichan AU - Luke, Amy AU - Dugas, Lara R AB - Background: Obesity is a major risk factor for hypertension, however, the physiologic mechanisms linking increased adiposity to elevations in blood pressure are not well described. An increase in resting energy expenditure (REE) is an obligatory consequence of obesity. Previous survey research has demonstrated that REE is an independent predictor of blood pressure, and eliminates the co-linear association of body mass index. This observation has received little attention and there have been no attempts to provide a causal explanation. Methods: At baseline in an international comparative study on obesity, 289 participants aged 25–44 were recruited from communities in the US, the Seychelles, Ghana and South Africa and had REE measured with indirect calorimetry. All participants were thought to be free of major illness. Results: In multivariate regression models, both systolic and diastolic blood pressure were positively associated with REE (p < 0.01), while body mass index and fat mass were negatively correlated with systolic blood pressure (p < 0.01, and p < 0.05 respectively), but not diastolic blood pressure. Conclusions: These data confirm previous reports and suggest that a common physiologic abnormality links REE and blood pressure. Elevated catecholamines, a putative metabolic characteristic of obesity, is a possible candidate to explain this association. The direct role of excess adipose tissue is open to question. DA - 2018-01-10 DB - OpenUCT DO - 10.1186/s12872-017-0737-5 DP - University of Cape Town J1 - BMC Cardiovascular Disorders LK - https://open.uct.ac.za PB - University of Cape Town PY - 2018 T1 - Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora TI - Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora UR - http://hdl.handle.net/11427/26821 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12872-017-0737-5
dc.identifier.urihttp://hdl.handle.net/11427/26821
dc.identifier.vancouvercitationCreber C, Cooper RS, Plange-Rhule J, Bovet P, Lambert EV, Forrester TE, et al. Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora. BMC Cardiovascular Disorders. 2018; http://hdl.handle.net/11427/26821.en_ZA
dc.language.isoen
dc.publisherBioMed Central
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rights.holderThe Author(s).
dc.sourceBMC Cardiovascular Disorders
dc.source.urihttps://bmccardiovascdisord.biomedcentral.com
dc.subject.otherHypertension
dc.subject.otherBlood pressure
dc.subject.otherObesity
dc.subject.otherResting energy expenditure
dc.titleIndependent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
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