Distribution of metals exposure and associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study”
| dc.contributor.author | Ettinger, Adrienne S | |
| dc.contributor.author | Bovet, Pascal | |
| dc.contributor.author | Plange-Rhule, Jacob | |
| dc.contributor.author | Forrester, Terrence E | |
| dc.contributor.author | Lambert, Estelle V | |
| dc.contributor.author | Lupoli, Nicola | |
| dc.contributor.author | Shine, James | |
| dc.contributor.author | Dugas, Lara R | |
| dc.contributor.author | Shoham, David | |
| dc.contributor.author | Durazo-Arvizu, Ramon A | |
| dc.contributor.author | Cooper, Richard S | |
| dc.contributor.author | Luke, Amy | |
| dc.date.accessioned | 2015-07-30T04:00:02Z | |
| dc.date.available | 2015-07-30T04:00:02Z | |
| dc.date.issued | 2014-11-05 | |
| dc.date.updated | 2015-01-15T17:58:04Z | |
| dc.description.abstract | Abstract Background Metals are known endocrine disruptors and have been linked to cardiometabolic diseases via multiple potential mechanisms, yet few human studies have both the exposure variability and biologically-relevant phenotype data available. We sought to examine the distribution of metals exposure and potential associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study” (METS), a prospective cohort study designed to assess energy balance and change in body weight, diabetes and cardiovascular disease risk in five countries at different stages of social and economic development. Methods Young adults (25–45 years) of African descent were enrolled (N = 500 from each site) in: Ghana, South Africa, Seychelles, Jamaica and the U.S.A. We randomly selected 150 blood samples (N = 30 from each site) to determine concentrations of selected metals (arsenic, cadmium, lead, mercury) in a subset of participants at baseline and to examine associations with cardiometabolic risk factors. Results Median (interquartile range) metal concentrations (μg/L) were: arsenic 8.5 (7.7); cadmium 0.01 (0.8); lead 16.6 (16.1); and mercury 1.5 (5.0). There were significant differences in metals concentrations by: site location, paid employment status, education, marital status, smoking, alcohol use, and fish intake. After adjusting for these covariates plus age and sex, arsenic (OR 4.1, 95% C.I. 1.2, 14.6) and lead (OR 4.0, 95% C.I. 1.6, 9.6) above the median values were significantly associated with elevated fasting glucose. These associations increased when models were further adjusted for percent body fat: arsenic (OR 5.6, 95% C.I. 1.5, 21.2) and lead (OR 5.0, 95% C.I. 2.0, 12.7). Cadmium and mercury were also related with increased odds of elevated fasting glucose, but the associations were not statistically significant. Arsenic was significantly associated with increased odds of low HDL cholesterol both with (OR 8.0, 95% C.I. 1.8, 35.0) and without (OR 5.9, 95% C.I. 1.5, 23.1) adjustment for percent body fat. Conclusions While not consistent for all cardiometabolic disease markers, these results are suggestive of potentially important associations between metals exposure and cardiometabolic risk. Future studies will examine these associations in the larger cohort over time. | |
| dc.identifier.apacitation | Ettinger, A. S., Bovet, P., Plange-Rhule, J., Forrester, T. E., Lambert, E. V., Lupoli, N., ... Luke, A. (2014). Distribution of metals exposure and associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study”. <i>Environmental Health</i>, http://hdl.handle.net/11427/13608 | en_ZA |
| dc.identifier.chicagocitation | Ettinger, Adrienne S, Pascal Bovet, Jacob Plange-Rhule, Terrence E Forrester, Estelle V Lambert, Nicola Lupoli, James Shine, et al "Distribution of metals exposure and associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study”." <i>Environmental Health</i> (2014) http://hdl.handle.net/11427/13608 | en_ZA |
| dc.identifier.citation | Ettinger, A. S., Bovet, P., Plange-Rhule, J., Forrester, T. E., Lambert, E. V., Lupoli, N., ... & Luke, A. (2014). Distribution of metals exposure and associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study”. Environmental Health, 13(1), 90. | |
| dc.identifier.ris | TY - Journal Article AU - Ettinger, Adrienne S AU - Bovet, Pascal AU - Plange-Rhule, Jacob AU - Forrester, Terrence E AU - Lambert, Estelle V AU - Lupoli, Nicola AU - Shine, James AU - Dugas, Lara R AU - Shoham, David AU - Durazo-Arvizu, Ramon A AU - Cooper, Richard S AU - Luke, Amy AB - Abstract Background Metals are known endocrine disruptors and have been linked to cardiometabolic diseases via multiple potential mechanisms, yet few human studies have both the exposure variability and biologically-relevant phenotype data available. We sought to examine the distribution of metals exposure and potential associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study” (METS), a prospective cohort study designed to assess energy balance and change in body weight, diabetes and cardiovascular disease risk in five countries at different stages of social and economic development. Methods Young adults (25–45 years) of African descent were enrolled (N = 500 from each site) in: Ghana, South Africa, Seychelles, Jamaica and the U.S.A. We randomly selected 150 blood samples (N = 30 from each site) to determine concentrations of selected metals (arsenic, cadmium, lead, mercury) in a subset of participants at baseline and to examine associations with cardiometabolic risk factors. Results Median (interquartile range) metal concentrations (μg/L) were: arsenic 8.5 (7.7); cadmium 0.01 (0.8); lead 16.6 (16.1); and mercury 1.5 (5.0). There were significant differences in metals concentrations by: site location, paid employment status, education, marital status, smoking, alcohol use, and fish intake. After adjusting for these covariates plus age and sex, arsenic (OR 4.1, 95% C.I. 1.2, 14.6) and lead (OR 4.0, 95% C.I. 1.6, 9.6) above the median values were significantly associated with elevated fasting glucose. These associations increased when models were further adjusted for percent body fat: arsenic (OR 5.6, 95% C.I. 1.5, 21.2) and lead (OR 5.0, 95% C.I. 2.0, 12.7). Cadmium and mercury were also related with increased odds of elevated fasting glucose, but the associations were not statistically significant. Arsenic was significantly associated with increased odds of low HDL cholesterol both with (OR 8.0, 95% C.I. 1.8, 35.0) and without (OR 5.9, 95% C.I. 1.5, 23.1) adjustment for percent body fat. Conclusions While not consistent for all cardiometabolic disease markers, these results are suggestive of potentially important associations between metals exposure and cardiometabolic risk. Future studies will examine these associations in the larger cohort over time. DA - 2014-11-05 DB - OpenUCT DO - 10.1186/1476-069X-13-90 DP - University of Cape Town J1 - Environmental Health LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Distribution of metals exposure and associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study” TI - Distribution of metals exposure and associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study” UR - http://hdl.handle.net/11427/13608 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/13608 | |
| dc.identifier.uri | http://dx.doi.org/10.1186/1476-069X-13-90 | |
| dc.identifier.vancouvercitation | Ettinger AS, Bovet P, Plange-Rhule J, Forrester TE, Lambert EV, Lupoli N, et al. Distribution of metals exposure and associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study”. Environmental Health. 2014; http://hdl.handle.net/11427/13608. | en_ZA |
| dc.language.rfc3066 | en | |
| dc.publisher.department | MRC/UCT RU for Exercise and Sport Medicine | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License | * |
| dc.rights.holder | Ettinger et al.; licensee BioMed Central Ltd. | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | * |
| dc.source | Environmental Health | en_ZA |
| dc.source.uri | http://www.ehjournal.net | |
| dc.subject.other | Arsenic | en_ZA |
| dc.subject.other | Cadmium | en_ZA |
| dc.subject.other | Cardiometabolic | en_ZA |
| dc.subject.other | Diabetes | en_ZA |
| dc.subject.other | Endocrine disruption | en_ZA |
| dc.subject.other | Lead | en_ZA |
| dc.subject.other | Mercury | en_ZA |
| dc.subject.other | Metals exposure | en_ZA |
| dc.subject.other | Obesity | en_ZA |
| dc.subject.other | Risk factor | en_ZA |
| dc.title | Distribution of metals exposure and associations with cardiometabolic risk factors in the “Modeling the Epidemiologic Transition Study” | |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | ||
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |