Supramolecular modification of selected antiretroviral drugs

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dc.contributor.advisorCaira, Mino Ren_ZA
dc.contributor.advisorBourne, Susanen_ZA
dc.contributor.authorEngel, Emile Richarden_ZA
dc.date.accessioned2015-04-02T14:18:25Z
dc.date.available2015-04-02T14:18:25Z
dc.date.issued2011en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractA number of antiretroviral drugs that are currently in use for anti-HIV therapy have extremely poor aqueous solubility. This, along with the fact that many of these pharmaceutical compounds possess potential hydrogen bond donor and acceptor functionalities, makes them ideal candidates for attempted supramolecular derivatisation. The primary objective of this study was to carry out cocrystal screening and attempt cyclodextrin complexation with nevirapine, efavirenz, lamivudine and zidovudine, with a view to identifying and isolating new solid forms of these drugs. Any new forms were to be characterised by a variety of analytical techniques, including thermal, spectroscopic and X-ray analysis and, where possible, such derivatives would be tested for any enhancements of drug solubility.en_ZA
dc.identifier.apacitationEngel, E. R. (2011). <i>Supramolecular modification of selected antiretroviral drugs</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/12675en_ZA
dc.identifier.chicagocitationEngel, Emile Richard. <i>"Supramolecular modification of selected antiretroviral drugs."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2011. http://hdl.handle.net/11427/12675en_ZA
dc.identifier.citationEngel, E. 2011. Supramolecular modification of selected antiretroviral drugs. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Engel, Emile Richard AB - A number of antiretroviral drugs that are currently in use for anti-HIV therapy have extremely poor aqueous solubility. This, along with the fact that many of these pharmaceutical compounds possess potential hydrogen bond donor and acceptor functionalities, makes them ideal candidates for attempted supramolecular derivatisation. The primary objective of this study was to carry out cocrystal screening and attempt cyclodextrin complexation with nevirapine, efavirenz, lamivudine and zidovudine, with a view to identifying and isolating new solid forms of these drugs. Any new forms were to be characterised by a variety of analytical techniques, including thermal, spectroscopic and X-ray analysis and, where possible, such derivatives would be tested for any enhancements of drug solubility. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Supramolecular modification of selected antiretroviral drugs TI - Supramolecular modification of selected antiretroviral drugs UR - http://hdl.handle.net/11427/12675 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12675
dc.identifier.vancouvercitationEngel ER. Supramolecular modification of selected antiretroviral drugs. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12675en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleSupramolecular modification of selected antiretroviral drugsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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