Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study

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dc.contributor.advisorMeintjes, Ernestaen_ZA
dc.contributor.advisorWarton, Christopheren_ZA
dc.contributor.authorBoonzaier, Natalie Rosellaen_ZA
dc.date.accessioned2014-07-28T18:16:05Z
dc.date.available2014-07-28T18:16:05Z
dc.date.issued2012en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractYears of research have demonstrated that prenatal exposure to alcohol contributes to a range of effects in exposed children. These include problems in attention and hyperactivity, deficits in memory and learning, and problems with social, as well as emotional development. Past research has demonstrated that the cerebellum is a significant target of the teratogenic effects of alcohol. The aim of this study was to determine whether prenatal exposure to alcohol has specific effects on the volumes of specific lobules of the cerebellum. Lobule tracing was performed manually, with Multitracer, using a refined methodology. Lobule volumes (normalized for total cerebellar cortical volume) were analysed as functions of diagnosis as well as alcohol exposure. Lobules IX and X were affected when analysing normalized volumes as a function of diagnosis, with the fetal alcohol syndrome diagnostic group being most specifically affected. Significant differences between sex groups were found only for right lobules I-V and left lobule VIII, and hemisphere differences were found in lobule X. When analysing normalized lobule volume as a function of alcohol exposure, in the left hemisphere, lobules I-V showed positive correlations with alcohol exposure, suggesting that this region is relatively spared. Lobule IX and the vermis of the right hemisphere showed negative correlations with alcohol exposure. The strongest negative correlations were found for measures of absolute alcohol per day averaged across the period of pregnancy as opposed to at time of conception. Overall findings suggest that prenatal alcohol exposure causes disproportionate reductions in volume in specific lobules of the cerebellums of children with fetal alcohol spectrum disorders.en_ZA
dc.identifier.apacitationBoonzaier, N. R. (2012). <i>Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3225en_ZA
dc.identifier.chicagocitationBoonzaier, Natalie Rosella. <i>"Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2012. http://hdl.handle.net/11427/3225en_ZA
dc.identifier.citationBoonzaier, N. 2012. Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Boonzaier, Natalie Rosella AB - Years of research have demonstrated that prenatal exposure to alcohol contributes to a range of effects in exposed children. These include problems in attention and hyperactivity, deficits in memory and learning, and problems with social, as well as emotional development. Past research has demonstrated that the cerebellum is a significant target of the teratogenic effects of alcohol. The aim of this study was to determine whether prenatal exposure to alcohol has specific effects on the volumes of specific lobules of the cerebellum. Lobule tracing was performed manually, with Multitracer, using a refined methodology. Lobule volumes (normalized for total cerebellar cortical volume) were analysed as functions of diagnosis as well as alcohol exposure. Lobules IX and X were affected when analysing normalized volumes as a function of diagnosis, with the fetal alcohol syndrome diagnostic group being most specifically affected. Significant differences between sex groups were found only for right lobules I-V and left lobule VIII, and hemisphere differences were found in lobule X. When analysing normalized lobule volume as a function of alcohol exposure, in the left hemisphere, lobules I-V showed positive correlations with alcohol exposure, suggesting that this region is relatively spared. Lobule IX and the vermis of the right hemisphere showed negative correlations with alcohol exposure. The strongest negative correlations were found for measures of absolute alcohol per day averaged across the period of pregnancy as opposed to at time of conception. Overall findings suggest that prenatal alcohol exposure causes disproportionate reductions in volume in specific lobules of the cerebellums of children with fetal alcohol spectrum disorders. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study TI - Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study UR - http://hdl.handle.net/11427/3225 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3225
dc.identifier.vancouvercitationBoonzaier NR. Effects of prenatal alcohol exposure on cerebellar volume in children an MRI study. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3225en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMEDen_ZA
dc.titleEffects of prenatal alcohol exposure on cerebellar volume in children an MRI studyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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